Abhinav A. Shukla - Bothell WA Ranjit R. Deshmukh - San Diego CA Steven M. Cramer - Schenectady NY James A. Moore - Troy NY
Assignee:
ISIS Pharmaceuticals, Inc. - Carlsbad CA Rensselaer Polytechin Institute - Troy NY
International Classification:
C07H 2100
US Classification:
536 254, 536 2541
Abstract:
A method for purifying oligonucleotides by displacement chromatography on anion-exchange media, using high affinity, low molecular weight (less than about 10000 Da) displacers, is disclosed. Several examples of high affinity, low molecular weight anionic displacers are provided, including polycyclic aromatic compounds having sulfonic acid moieties attached thereon. The efficacy of the technique for high resolution separation of oligonucleotides is demonstrated for an industrial mixture.
Method For Selecting A High Affinity, Low Molecular Weight Displacer For Oligonucleotide Purification
A method for purifying oligonucleotides by displacement chromatography on anion-exchange media, using high affinity, low molecular weight (less than about 10000 Da) displacers, is disclosed. Several examples of high affinity, low molecular weight anionic displacers are provided, including polycyclic aromatic compounds having sulfonic acid moieties attached thereon. The efficacy of the technique for high resolution separation of oligonucleotides is demonstrated for an industrial mixture.
Mark A. Stanish - Seattle WA Stan L. Floyd - Enumclaw WA Steven M. Cramer - Lodi WI
Assignee:
Weyerhaeuser Company - Federal Way WA
International Classification:
G01N 2918 F26B 1310
US Classification:
73597
Abstract:
A method for determining crook potential of wood is described. One embodiment comprises nondestructively obtaining lengthwise shrinkage rates (from a third party or by direct measurement) of wood and then determining crook potential of the wood based on the lengthwise shrinkage rates. Where the wood comprises lumber, lengthwise shrinkage rate measurements typically are made on at least one major planar surface of the lumber. The method typically comprises determining lengthwise shrinkage rates two or more measuring points separated by a predetermined distance, such as at substantially one-foot intervals along the lumber. Particular embodiments of the present invention determine lengthwise shrinkage rates using infrared radiation, microwave radiation, electricity, ultrasound energy, and combinations thereof Working embodiments of the method use ultrasound energy to determine lengthwise shrinkage rates. For example, one working embodiment measures the speed of an ultrasound pulse through wood to determine the modulus of elasticity (MOE) of the wood which can then be correlated to the lengthwise shrinkage rate. In another example, lengthwise shrinkage rate can be determined from the speed of an ultrasound pulse using an empirically derived formula, such as an exponential formula.
Mark A. Stanish - Seattle WA Stan L. Floyd - Enumclaw WA Steven M. Cramer - Lodi WI
Assignee:
Weyerhaeuser Company - Federal Way WA
International Classification:
G01N 3346 G01N 2900 G01R 2726
US Classification:
73597
Abstract:
A method for determining twist potential of wood is described. One embodiment of the method comprises nondestructively obtaining a grain angle of wood, such as trees or lumber, and then determining twist potential of the wood based on the grain angle. Where the wood comprises lumber, grain angle determinations typically are made on at least one major surface of the lumber. The method typically comprises determining grain angle at at least two measuring locations separated by a predetermined distance, such as at substantially one-foot intervals along the board. The method also can further comprise obtaining at least one fiber dive angle. Particular embodiments of the present invention determine grain angle using infrared radiation, microwave radiation, light energy (such as by using a laser), electricity, ultrasound energy, and combinations thereof. Working embodiments of the method used light energy and ultrasound energy to determine grain angle. For example, a first transmission speed of an ultrasound pulse through the board was determined along a first path and along a second path.
Mark A. Stanish - Seattle WA Stan L. Floyd - Enumclaw WA Steven M. Cramer - Lodi WI
Assignee:
Weyerhaeuser Company - Federal Way WA
International Classification:
G01N 2918 B23Q 1507 B27B 100 B26D 540
US Classification:
73597
Abstract:
A method for determining warp potential of wood. One embodiment comprises nondestructively obtaining lengthwise shrinkage rates and grain angles of wood--such as trees, logs, or lumber--then determining warp potential of the wood based on the lengthwise shrinkage rates and grain angles. The method typically comprises measuring plural lengthwise shrinkage rates and plural grain angles to determine warp potential. Where the wood comprises lumber, lengthwise shrinkage rate and grain angle measurements typically are made on at least one major planar surface of the lumber at at least two measuring points separated by a predetermined distance, such as at substantially one-foot intervals along the lumber. Particular embodiments of the present invention determine lengthwise shrinkage rates using electromagnetic energy, acoustic energy, and combinations thereof. Working embodiments of the method use ultrasound energy to determine lengthwise shrinkage rates and grain angles.
Steven C. Cramer - Brookline MA Seth P. Finklestein - Needham MA
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
A61B 5103
US Classification:
600595
Abstract:
The invention features apparatus and methods for measuring motor events of a subject, e. g. , a human subject, where the motor events have a force component or both a frequency and force component. The apparatus include a transducer, adapted to generate an analog signal corresponding to frequency and/or force of the subject's motor event, e. g. , a repetitive motion; an amplifier, which amplifies the analog signal; an analog-to-digital (A/D) converter, which converts the analog signal into a digital signal; and a computer. The computer is programmed to receive the digital signal as input, store the digital signal for subsequent retrieval, retrieve the stored digital signal for processing, and process the stored digital signal. The processing includes the measurement of mean force amongst the set of individual motor events over time and measurement of the mean frequency of the set of individual motor events over time.
Systems And Methods For Manufacturing Biologically-Produced Products
- Cambridge MA, US - Troy NY, US Laura Crowell - Cambridge MA, US Alan Stockdale - Providence RI, US Richard Dean Braatz - Arlington MA, US Amos Enshen Lu - Cambridge MA, US Steven Cramer - Troy NY, US Steven Timmick - Troy NY, US Nicholas Vecchiarello - Troy NY, US Chaz Goodwine - Troy NY, US Craig A. Mascarenhas - Brookline MA, US
Assignee:
Massachusetts Institute of Technology - Cambridge MA Rensselaer Polytechnic Institute - Troy NY
Aspects of the present disclosure relate to systems and methods for manufacturing biologically-produced pharmaceutical products. Some of the systems described herein comprise an upstream component comprising a bioreactor and at least one filter (e.g., a filter probe) integrated with a downstream component comprising a purification module comprising at least a first partitioning unit and a second partitioning unit. In some embodiments; these integrated biomanufacturing systems may be operated under continuous or conditions and may be capable of efficiently producing pure, high-quality pharmaceutical products.
UCI Medical Center Neurology 101 The City Dr S, Orange, CA 92868 7144567002 (Phone)
Languages:
English
Education:
Medical School Keck School Of Medicine Of The Univ Of Southern California Graduated: 1988 Medical School Mass Gen Hospital Graduated: 1988 Medical School UCLA Med Center Graduated: 1988
Dr. Cramer graduated from the University of Southern California Keck School of Medicine in 1988. He works in Orange, CA and specializes in Neurology and Psychiatry. Dr. Cramer is affiliated with UC Irvine Medical Center.
Steven Cramer, Orange CA
Work:
Urgentcare Irvine Medical Center
101 The City Dr S, Orange, CA 92868
American Board of Psychiatry and Neurology Certification in Neurology (Psychiatry and Neurology) American Board of Psychiatry and Neurology Sub-certificate in Vascular Neurology (Psychiatry and Neurology)
Houlihan Lokey
Managing Director
Imperial Capital, Llc 2006 - Oct 2018
Managing Director
Lbi Media 2004 - 2005
Chief Financial Officer
Credit Suisse 2001 - 2002
Vice President
Donaldson, Lufkin & Jenrette 1999 - 2001
Vice President
Education:
Harvard Business School
Master of Business Administration, Masters
Stanford University
Bachelors, Bachelor of Arts, Economics
Skills:
Corporate Finance Mergers and Acquisitions Debt and Equity Financing Leveraged Finance Capital Markets Growth Capital Gaming Industry Media Digital Media Casino Gaming Online Gaming Private Placements Private Equity Special Situations Restructuring Credit Corporate Development Valuation Financial Modeling Hedge Funds Alternative Investments Venture Capital Investor Relations Middle Market Principal Investments Hospitality Industry
University of California, Los Angeles 2006 - 2009
Master of Science, Master of Business Administration, Masters, Computer Science
Temple University 1998 - 2002
Bachelors, Bachelor of Science, Computer Science
Steven Cramer, Charles O. Hartman, Nathan McClain and Lee Varon are expected to be the featured poets that afternoon. Additionally, an accompanying violin performance from Elizabeth Burke is scheduled.