Steven A Cramer

US Patent:

58852310, Mar 23, 1999

Filed:

Jan 7, 1997

Appl. No.:

8/779766

Inventors:

Steven C. Cramer - Brookline MA
Seth P. Finklestein - Needham MA

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

A61B 5103

US Classification:

600595

Abstract:

The invention features apparatus and methods for measuring motor events of a subject, e. g. , a human subject, where the motor events have a force component or both a frequency and force component. The apparatus include a transducer, adapted to generate an analog signal corresponding to frequency and/or force of the subject's motor event, e. g. , a repetitive motion; an amplifier, which amplifies the analog signal; an analog-to-digital (A/D) converter, which converts the analog signal into a digital signal; and a computer. The computer is programmed to receive the digital signal as input, store the digital signal for subsequent retrieval, retrieve the stored digital signal for processing, and process the stored digital signal. The processing includes the measurement of mean force amongst the set of individual motor events over time and measurement of the mean frequency of the set of individual motor events over time.

US Patent:

20230053902, Feb 23, 2023

Filed:

Mar 9, 2022

Appl. No.:

17/690876

Inventors:

- Cambridge MA, US
- Troy NY, US
Laura Crowell - Cambridge MA, US
Alan Stockdale - Providence RI, US
Richard Dean Braatz - Arlington MA, US
Amos Enshen Lu - Cambridge MA, US
Steven Cramer - Troy NY, US
Steven Timmick - Troy NY, US
Nicholas Vecchiarello - Troy NY, US
Chaz Goodwine - Troy NY, US
Craig A. Mascarenhas - Brookline MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA
Rensselaer Polytechnic Institute - Troy NY

International Classification:

C12M 1/00
C12M 1/34
C07K 1/20
C07K 16/00
G16C 20/20

Abstract:

Aspects of the present disclosure relate to systems and methods for manufacturing biologically-produced pharmaceutical products. Some of the systems described herein comprise an upstream component comprising a bioreactor and at least one filter (e.g., a filter probe) integrated with a downstream component comprising a purification module comprising at least a first partitioning unit and a second partitioning unit. In some embodiments; these integrated biomanufacturing systems may be operated under continuous or conditions and may be capable of efficiently producing pure, high-quality pharmaceutical products.

US Patent:

20200224144, Jul 16, 2020

Filed:

Mar 30, 2018

Appl. No.:

16/499780

Inventors:

- Cambridge MA, US
- Troy NY, US
Laura Crowell - Cambridge MA, US
Alan Stockdale - Providence RI, US
Richard Dean Braatz - Arlington MA, US
Amos Enshen Lu - Cambridge MA, US
Steven Cramer - Troy NY, US
Steven Timmick - Troy NY, US
Nicholas Vecchiarello - Troy NY, US
Chaz Goodwine - Troy NY, US
Craig A. Mascarenhas - Brookline MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA
Rensselaer Polytechnic Institute - Troy NY

International Classification:

C12M 1/00
C12M 1/34

Abstract:

Aspects of the present disclosure relate to systems and methods for manufacturing biologically-produced pharmaceutical products. Some of the systems described herein comprise an upstream component comprising a bioreactor and at least one filter (e.g., a filter probe) integrated with a downstream component comprising a purification module comprising at least a first partitioning unit and a second partitioning unit. In some embodiments, these integrated biomanufacturing systems may be operated under continuous or conditions and may be capable of efficiently producing pure, high-quality pharmaceutical products.