Steven A Elmore

US Patent:

8114893, Feb 14, 2012

Filed:

Dec 17, 2009

Appl. No.:

12/641063

Inventors:

Jonathan Bayldon Baell - Bundoora, AU
Chinh Thien Bui - Balwyn North, AU
Peter Colman - East Melbourne, AU
Danette A. Dudley - Pacifica CA, US
Wayne J. Fairbrother - Burlingame CA, US
John A. Flygare - Burlingame CA, US
Guillaume Laurent Lessene - Coburg, AU
Chudi Ndubaku - San Francisco CA, US
George Nikolakopoulos - Thomastown, AU
Carl Steven Rye - CR Epsom, GB
Brad Edmund Sleebs - Reservoir, AU
Brian John Smith - Sunbury, AU
Keith Geoffrey Watson - Surry Hills, AU
Steven W. Elmore - Northbrook IL, US
Andrew M. Petros - Mundelein IL, US
Andrew J. Souers - Evanston IL, US
Peter Czabotar - Melbourne, AU

Assignee:

Genentech, Inc. - South San Francisco CA
Abbott Laboratories - Abbott Park IL
The Walter and Eliza Hall Medical Research Institute - Parkville

International Classification:

C07D 417/14
A61K 31/5377
A61K 31/538
A61K 31/496
A61K 31/498
A61K 31/4709

US Classification:

514314, 514249, 5142305, 5142338, 51425306, 51426621, 514367, 51421301, 5142621, 51425505, 544235, 544363, 544128, 544353, 544284, 544262, 544405, 548159, 540593, 546165

Abstract:

In one aspect, the present invention provides for a compound of Formula I.

US Patent:

8232273, Jul 31, 2012

Filed:

Dec 17, 2009

Appl. No.:

12/641141

Inventors:

Jonathan Bayldon Baell - Bundoora, AU
Chinh Thien Bui - Balwyn North, AU
Peter Colman - East Melbourne, AU
Peter Czabotar - Melbourne, AU
Danette A. Dudley - Pacifica CA, US
Wayne J. Fairbrother - Burlingame CA, US
John A. Flygare - Burlingame CA, US
Guillaume Laurent Lessene - Coburg, AU
Chudi Ndubaku - San Francisco CA, US
George Nikolakopoulos - Thomastown, AU
Brad Edmund Sleebs - Reservoir, AU
Brian John Smith - Sunbury, AU
Keith Geoffrey Watson - Surry Hills, AU
Steven W. Elmore - Northbrook IL, US
Lisa A. Hasvold - Grayslake IL, US
Andrew M. Petros - Mundelein IL, US
Andrew J. Souers - Evanston IL, US
Zhi-Fu Tao - Gurnee IL, US
Le Wang - Vernon Hills IL, US
Xilu Wang - Grayslake IL, US
Kurt Deshayes - San Francisco CA, US

Assignee:

Genentech, Inc. - South San Francisco CA
Abbott Laboratories - Abbott Park IL
The Walter and Eliza Hall Institute of Medical Research - Victoria

International Classification:

A61K 31/5377
C07D 413/14

US Classification:

5142338, 544111

Abstract:

In one aspect, the present invention provides for a compound of Formula I.

US Patent:

8518970, Aug 27, 2013

Filed:

Jan 10, 2012

Appl. No.:

13/347364

Inventors:

Jonathan Bayldon Baell - Bundoora, AU
Chinh Thien Bui - Balwyn North, AU
Peter Colman - East Melbourne, AU
Danette A. Dudley - Pacifica CA, US
Wayne J. Fairbrother - Burlingame CA, US
John A. Flygare - Burlingame CA, US
Guillaume Laurent Lessene - Coburg, AU
Chudi Ndubaku - San Francisco CA, US
George Nikolakopoulos - Thomastown, AU
Carl Steven Rye - Epsom, GB
Brad Edmund Sleebs - Reservoir, AU
Brian John Smith - Sunbury, AU
Keith Geoffrey Watson - Surry Hills, AU
Steven W. Elmore - Northbrook IL, US
Andrew M. Petros - Mundelein IL, US
Andrew J. Souers - Evanston IL, US
Peter Czabotar - Melbourne, AU

Assignee:

AbbVie Inc. - North Chicago IL
Genentech, Inc. - South San Francisco CA
The Walter and Eliza Hall Institute of Medical Research - Parkville, Victoria

International Classification:

C07D 417/14
A61K 31/5377
A61K 31/538
A61K 31/496
A61K 31/498
A61K 31/4709

US Classification:

514314, 514249, 5142305, 5142338, 51425306, 51426621, 514367, 51421301, 5142621, 51425505, 544235, 544363, 544128, 544353, 544284, 544262, 544405, 548159, 540593, 546165

Abstract:

In one aspect, the present invention provides for a compound of Formula I.

US Patent:

20140005190, Jan 2, 2014

Filed:

Jun 27, 2013

Appl. No.:

13/929701

Inventors:

- Parkville, AU
DANETTE A. DUDLEY - PACIFICA CA, US
WAYNE J. FAIRBROTHER - BURLINGAME CA, US
JOHN A. FLYGARE - BURLINGAME CA, US
GUILLAUME LAURENT LESSENE - BUNDOORA, AU
CHUDI NDUBAKU - THOMASTOWN, AU
GEORGE NIKOLAKOPOULOS - THOMASTOWN, AU
CARL STEVEN RYE - EPSOM, CA
BRAD EDMUND SLEEBS - RESERVOIR, AU
BRIAN JOHN SMITH - SUNBURY, AU
KEITH GEOFFREY WATSON - SURRY HILLS, AU
STEVEN W. ELMORE - NORTHBROOK IL, US
ANDREW M. PETROS - MUNDELEIN IL, US
ANDREW J. SOUERS - EVANSTON IL, US
PETER CZABOTAR - MELBOURNE, AU

Assignee:

Genentech, Inc. - South San Francisco CA
The Walter and Eliza Hall Institute of Medical Research - Parkville
AbbVie Inc. - North Chicago IL

International Classification:

C07D 487/04
C07D 417/12
C07D 417/14

US Classification:

5142338, 546165, 514314, 548190, 514371, 548163, 514367, 544105, 544262, 5142621

Abstract:

In one aspect, the present invention provides for a compound of Formula Iin which in Formula I, the variables X, X, X, X, R, B, L, E, A and the subscript n are as defined herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formula I as well as methods for using compounds of Formula I for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-expression of Bcl-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bcl-xproteins.