Steven M Fischer

US Patent:

6664053, Dec 16, 2003

Filed:

Feb 9, 2001

Appl. No.:

09/762724

Inventors:

Joseph A. Kovacs - Potomac MD
Shengning Huang - N. Potomac MD
Henry Masur - Bethesda MD
Steven H. Fischer - Rockville MD
Vee J. Gill - Potomac MD
Qin Mei - North Wales PA

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

C07H 2104

US Classification:

435 6, 435 912, 435 5, 435 911, 536 231

Abstract:

Particularly sensitive techniques for the detection of in clinical samples are disclosed. These techniques relate to the PCR amplification and/or detection of human- major surface glycoprotein (MSG) gene sequences. Also disclosed are seven novel genes encoding human- MSG, and the proteins encoded for by these genes. These genes provide proof that human- MSG is encoded for by a highly conserved gene family, and that the conesponding proteins have a very highly conserved region of about 100 amino acids near their C-terminal end. This highly conserved carboxy-terminal region has a significantly different sequence than that found in rat-derived MSG.

US Patent:

7271781, Sep 18, 2007

Filed:

Mar 1, 2001

Appl. No.:

10/220212

Inventors:

Steven H. Fischer - Rockville MD, US
Jang B. Rampal - Yorba Linda CA, US
Gary A. Fahle - Silver Spring MD, US
Patricia S. Conville - Rockville MD, US

Assignee:

The United States of America as Represented by the Secretary of the Department of Health and Human Services - Washington DC
Beckman Coulter, Inc. - Fullerton CA

International Classification:

C12Q 1/68

US Classification:

345 6, 435 912

Abstract:

A method for species-specific identification of a species is provided. Also disclosed is a method for identifying the species of present in a sample. A device is disclosed for the detection of -specific oligonucleotides are also disclosed, as are kits.

US Patent:

20040043409, Mar 4, 2004

Filed:

Sep 2, 2003

Appl. No.:

10/654416

Inventors:

Joseph Kovacs - Potomac MD, US
Shengning Huang - N. Potomac MD, US
Henry Masur - Bethesda MD, US
Steven Fischer - Rockville MD, US
Vee Gill - Potomac MD, US
Qin Mei - North Wales PA, US

Assignee:

The Government of the USA represented by Secretary of the Department of Health & Human Services

International Classification:

C12Q001/68
C07H021/04
C07K014/195

US Classification:

435/006000, 435/069300, 435/320100, 435/252300, 530/395000, 536/023700

Abstract:

Particularly sensitive techniques for the detection of in clinical samples are disclosed. These techniques relate to the PCR amplification and/or detection of human-major surface glycoprotein (MSG) gene sequences. Also disclosed are seven novel genes encoding human-MSG, and the proteins encoded for by these genes. These genes provide proof that human-MSG is encoded for by a highly conserved gene family, and that the corresponding proteins have a very highly conserved region of about 100 amino acids near their C-terminal end. This highly conserved carboxy-terminal region has a significantly different sequence than that found in rat-derived MSG.