Steven M Greco

US Patent:

8642543, Feb 4, 2014

Filed:

May 21, 2009

Appl. No.:

12/470427

Inventors:

Nikolaos Tezapsidis - West Orange NJ, US
Steven Greco - Carlstadt NJ, US
Mark Smith - Chagrin Falls OH, US

Assignee:

Neurotez, Inc. - Bridgewater NJ

International Classification:

A61K 38/22

US Classification:

514 58, 514 178, 514 182

Abstract:

The described invention provides methods for treating or preventing progression of a progressive cognitive disease, disorder or condition, and methods for improving resilience of cognitive function in a subject in need thereof.

US Patent:

20100113358, May 6, 2010

Filed:

Nov 4, 2009

Appl. No.:

12/612613

Inventors:

Nikolaos Tezapsidis - West Orange NJ, US
Steven J. Greco - Carlstadt NJ, US
Mark Smith - Cleveland OH, US

International Classification:

A61K 38/22
A61P 25/00
A61P 25/28
C12Q 1/48
G01N 33/573
G01N 33/00

US Classification:

514 12, 435 15, 435 74, 435 792

Abstract:

The present disclosure provides compositions containing a leptin product and methods of clinical therapy and diagnostic methods for progressive cognitive disorders. According to one aspect, the described invention provides a method for treating a progressive cognitive disorder. According to another aspect, the described invention provides a method for improving resilience of cognitive function in a subject in need thereof. According to another aspect, the described invention provides a method for identifying an effective therapeutic agent for treating a progressive cognitive dysfunction disease or disorder that results from at least one of accumulation of Aβ, hyperphosphorylation of tau, or accumulation of neurofibrillary tangles.

US Patent:

20120231457, Sep 13, 2012

Filed:

Mar 9, 2012

Appl. No.:

13/415940

Inventors:

Nikolaos Tezapsidis - West Orange NJ, US
Steven J. Greco - Carlstadt NJ, US

International Classification:

C12Q 1/68

US Classification:

435 611

Abstract:

The described invention provides compositions and methods for assessing a genetic risk of developing late-onset Alzheimer's disease (LOAD) in a subject by analyzing haplotypes of human Apolipoprotein E (APOE) and Translocase of Outer Mitochondrial Membrane 40 homolog (TOMM40) genes using a PCR- and restriction digest-based approach.

US Patent:

20130065825, Mar 14, 2013

Filed:

Sep 13, 2012

Appl. No.:

13/613030

Inventors:

Steven J. Greco - Carlstadt NJ, US
Nikolaos Tezapsidis - West Orange NJ, US

Assignee:

NEUROTEZ, INC. - Bridgewater NJ

International Classification:

A61K 38/22
A61P 25/28
C12N 5/0793

US Classification:

514 58, 435375

Abstract:

The described invention provides methods and compositions for enhancing the enzymatic activity of Sirtuin family members by using Leptin, Leptin analogs, Leptin derivatives, or Leptin agonists. The described invention further provides compositions and methods for delaying senescence or cell death in neurons using the compositions.