Steven T Hebert

US Patent:

6337391, Jan 8, 2002

Filed:

Sep 28, 1998

Appl. No.:

09/162021

Inventors:

H. William Harris - Dover MA
Edward M. Brown - Milton MA
Steven C. Hebert - Wellesley MA

Assignee:

Brighams Womens Hospital - Boston MA

International Classification:

C12N 1500

US Classification:

536 235, 536 231, 435 691, 4353201, 435325, 4352523, 43525411, 530350

Abstract:

Polycation-sensing receptors present in aquatic species and methods of regulating polycation-sensing receptor-mediated functions in aquatic species are described.

US Patent:

7038014, May 2, 2006

Filed:

Dec 10, 2001

Appl. No.:

10/016496

Inventors:

H. William Harris - Dover MA, US
Edward M. Brown - Milton MA, US
Steven C. Hebert - Wellesley MA, US

Assignee:

Brigham and Women's Hospital - Boston MA

International Classification:

C07K 14/435
C07H 21/04
C12N 15/00

US Classification:

530350, 530300, 536 231, 435 71, 435 691, 4352351, 435325, 435375, 4353201

Abstract:

Polycation-sensing receptors present in aquatic species and methods of regulating polycation-sensing receptor-mediated functions in aquatic species are described.

US Patent:

57635692, Jun 9, 1998

Filed:

Jun 7, 1995

Appl. No.:

8/484565

Inventors:

Edward M. Brown - Milton MA
Steven C. Hebert - Wellesley MA
James E. Garrett - Salt Lake City UT

Assignee:

The Brigham and Women's Hospital, Inc - Boston MA
NPS Pharmaceuticals, Inc. - Salt Lake City UT

International Classification:

C07K 14705

US Classification:

530324

Abstract:

The present invention features calcium receptor polypeptides and fragments thereof. Uses of a calcium receptor polypeptide include providing a polypeptide having the activity of a calcium receptor polypeptide. Calcium receptor polypeptide fragments can be used, for example, to generate antibodies to a calcium receptor polypeptide.

US Patent:

59623144, Oct 5, 1999

Filed:

Oct 3, 1997

Appl. No.:

8/943986

Inventors:

Edward M. Brown - Milton MA
Steven C. Hebert - Wellesley MA
James E. Garrett - Salt Lake City UT

Assignee:

NPS Pharmaceuticals, Inc. - Salt Lake City UT
Brigham and Women's Hospital - Boston MA

International Classification:

C12N 1563
C12N 1511
C12N 1512
C07K 700

US Classification:

4353201

Abstract:

The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca. sup. 2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.

US Patent:

56889380, Nov 18, 1997

Filed:

Jun 7, 1995

Appl. No.:

8/485588

Inventors:

Edward M. Brown - Milton MA
Forrest H. Fuller - Salt Lake City UT
Steven C. Hebert - Wellesley MA
James E. Garrett - Salt Lake City UT

Assignee:

The Brigham & Women's Hospital, Inc. - Boston MA
NPS Pharmaceuticals, Inc. - Salt Lake City UT

International Classification:

C07K 4705
C12N 1512

US Classification:

536 235

Abstract:

The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca. sup. 2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.