Steven E Hebert

US Patent:

6337391, Jan 8, 2002

Filed:

Sep 28, 1998

Appl. No.:

09/162021

Inventors:

H. William Harris - Dover MA
Edward M. Brown - Milton MA
Steven C. Hebert - Wellesley MA

Assignee:

Brighams Womens Hospital - Boston MA

International Classification:

C12N 1500

US Classification:

536 235, 536 231, 435 691, 4353201, 435325, 4352523, 43525411, 530350

Abstract:

Polycation-sensing receptors present in aquatic species and methods of regulating polycation-sensing receptor-mediated functions in aquatic species are described.

US Patent:

7038014, May 2, 2006

Filed:

Dec 10, 2001

Appl. No.:

10/016496

Inventors:

H. William Harris - Dover MA, US
Edward M. Brown - Milton MA, US
Steven C. Hebert - Wellesley MA, US

Assignee:

Brigham and Women's Hospital - Boston MA

International Classification:

C07K 14/435
C07H 21/04
C12N 15/00

US Classification:

530350, 530300, 536 231, 435 71, 435 691, 4352351, 435325, 435375, 4353201

Abstract:

Polycation-sensing receptors present in aquatic species and methods of regulating polycation-sensing receptor-mediated functions in aquatic species are described.

US Patent:

53567757, Oct 18, 1994

Filed:

Jul 29, 1992

Appl. No.:

7/921178

Inventors:

Steven C. Hebert - Wellesley MA
Kevin Ho - Newton MA

Assignee:

Brigham & Women's Hospital - Boston MA

International Classification:

C12N 1512
C12N 1510
C12N 1563

US Classification:

435 6

Abstract:

This invention is directed to the cloning of the gene which encodes an ATP-sensitive K. sup. + channel in rat outer medulla cells, isolated cDNA sequences which encode said ATP-sensitive K. sup. + channels, isolated proteins produced by said cDNA sequences, and agents capable of binding to said proteins. Further included in the invention are methods for identifying other members of the family of ATP-sensitive potassium channels (the ROMK1 family of channel proteins), identifying, isolating, and cloning the genes which encode ROMK1 associated polypeptides, identifying agents capable of binding to other members of the family, modulating expression of said family of ATP-sensitive potassium channels, and modulating the activity of said family of ATP-sensitive potassium channels. Additionally, included in the invention are methods for identifying drugs which function as K. sub. ATP channel openers and K. sub.

US Patent:

57635692, Jun 9, 1998

Filed:

Jun 7, 1995

Appl. No.:

8/484565

Inventors:

Edward M. Brown - Milton MA
Steven C. Hebert - Wellesley MA
James E. Garrett - Salt Lake City UT

Assignee:

The Brigham and Women's Hospital, Inc - Boston MA
NPS Pharmaceuticals, Inc. - Salt Lake City UT

International Classification:

C07K 14705

US Classification:

530324

Abstract:

The present invention features calcium receptor polypeptides and fragments thereof. Uses of a calcium receptor polypeptide include providing a polypeptide having the activity of a calcium receptor polypeptide. Calcium receptor polypeptide fragments can be used, for example, to generate antibodies to a calcium receptor polypeptide.

US Patent:

59623144, Oct 5, 1999

Filed:

Oct 3, 1997

Appl. No.:

8/943986

Inventors:

Edward M. Brown - Milton MA
Steven C. Hebert - Wellesley MA
James E. Garrett - Salt Lake City UT

Assignee:

NPS Pharmaceuticals, Inc. - Salt Lake City UT
Brigham and Women's Hospital - Boston MA

International Classification:

C12N 1563
C12N 1511
C12N 1512
C07K 700

US Classification:

4353201

Abstract:

The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca. sup. 2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.

US Patent:

56889380, Nov 18, 1997

Filed:

Jun 7, 1995

Appl. No.:

8/485588

Inventors:

Edward M. Brown - Milton MA
Forrest H. Fuller - Salt Lake City UT
Steven C. Hebert - Wellesley MA
James E. Garrett - Salt Lake City UT

Assignee:

The Brigham & Women's Hospital, Inc. - Boston MA
NPS Pharmaceuticals, Inc. - Salt Lake City UT

International Classification:

C07K 4705
C12N 1512

US Classification:

536 235

Abstract:

The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca. sup. 2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.