Steven K Lin

US Patent:

20210147537, May 20, 2021

Filed:

Nov 24, 2020

Appl. No.:

17/103308

Inventors:

- Seoul, KR
- Austin TX, US
Steven Hsesheng Lin - Pearland TX, US
Amrish Sharma - Houston TX, US

International Classification:

C07K 16/28

Abstract:

Provided herein are molecules having an antigen binding fragment that immunospecifically binds to BTN1A1, such as anti-BTN1A1 antibodies. These molecules include those having an antigen binding fragment that immunospecifically binds to glycosylated BTN1A1, such as anti-glycosylated BTN1A1 antibodies. Methods of making and using these molecules are also provided, including methods of using them in cancer therapies, or as cancer diagnostics.

US Patent:

20200096519, Mar 26, 2020

Filed:

Sep 18, 2019

Appl. No.:

16/574821

Inventors:

Erin Heather SEELEY - Morgantown WV, US
Katy Ryan Smoot - Morgantown WV, US
Heather Rae Anderson - Morgantown WV, US
Steven H. Lin - Houston TX, US

International Classification:

G01N 33/68
G01N 1/30
G01N 1/40
H01J 49/16
H01J 49/04

Abstract:

This disclosure relates to the use of Matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI) to assay tissue samples. Methods of analyzing a tissue sample may generally comprise generating sample ions directly from the tissue sample using a MALDI ionization source, receiving the ions into a mass spectrometer, identifying at least one esophageal tumor related compound in the sample from results from the mass spectrometer, comparing the at least one identified esophageal tumor related compound in the sample to one or more known esophageal tumor profiles, and identifying at least one condition related to the sample from the comparison of the at least one identified esophageal tumor related compound to the one or more known esophageal tumor profiles. The mass spectrometer may be a quadrupole mass spectrometer, a time of flight mass spectrometer, an Orbitrap mass spectrometer, or an ion trap mass spectrometer.

US Patent:

20180355035, Dec 13, 2018

Filed:

Dec 1, 2016

Appl. No.:

15/781071

Inventors:

- Seoul, KR
- Austin TX, US
Steven Hsesheng Lin - Pearland TX, US
Amrish Sharma - Houston TX, US

International Classification:

C07K 16/28

Abstract:

Provided herein are molecules having an antigen binding fragment that immunospecifically binds to BTN1A1, such as anti-BTN1A1 antibodies. These molecules include those having an antigen binding fragment that immunospecifically binds to glycosylated BTN1A1, such as anti-glycosylated BTN1A1 antibodies. Methods of making and using these molecules are also provided, including methods of using them in cancer therapies, or as cancer diagnostics.