Steven C Mathieu

US Patent:

20050059632, Mar 17, 2005

Filed:

Jun 30, 2004

Appl. No.:

10/882893

Inventors:

Richard Storer - Folkestone, GB
Adel Moussa - Burlington MA, US
Jingyang Wang - Acton MA, US
Narayan Chaudhuri - Acton MA, US
Steven Mathieu - Salem NH, US
Alistair Stewart - Somerville MA, US

International Classification:

A61K031/7076
A61K031/7072
C07H019/22
C07H019/048

US Classification:

514045000, 514049000, 536001110, 536027100, 536028100, 536055300

Abstract:

An improved process for the preparation of 2′-modified nucleosides and 2′-deoxy-nucleosides, such as, β-L-2′-deoxy-thymidine (LdT), is provided. In particular, the improved process is directed to the synthesis of a 2′-deoxynucleoside that may utilize different starting materials but that proceeds via a chloro-sugar intermediate or via a 2,2′-anhydro-1-furanosyl-nucleobase intermediate. Where an 2,2′-anhydro--furanosyl base intermediate is utilized, a reducing agent, such as Red-Al, and a sequestering agent, such as 15-crown-5 ether, that cause an intramolecular displacement reaction and formation of the desired nucleoside product in good yields are employed. An alternative process of the present invention utilizes a 2,2′-anhydro-1-furanosyl base intermediate without a sequestering agent to afford 2′-deoxynucleosides in good yields. The compounds made according to the present invention may be used as intermediates in the preparation of other nucleoside analogues, or may be used directly as antiviral and/or antineoplastic agents.

US Patent:

20040181051, Sep 16, 2004

Filed:

Dec 23, 2003

Appl. No.:

10/746395

Inventors:

Richard Storer - Folkestone, GB
Adel Moussa - Burlington MA, US
Steven Mathieu - Salem NH, US

International Classification:

C07H019/067
C07H019/073

US Classification:

536/027100, 536/028500, 536/028400

Abstract:

Provided is a single-step process for the selective 3′-acylation of a ribofuranosyl 2′ or 3′-branched nucleoside. These compounds are useful as antiviral agents, and in particular, can be used to treat Flaviviridae infections in a host in need thereof.

US Patent:

20210363154, Nov 25, 2021

Filed:

Mar 29, 2021

Appl. No.:

17/216076

Inventors:

- Cambridge MA, US
- Boston MA, US
Steven L. MATHIEU - Somerville MA, US
Yukari Y. PERRELLA - Cambridge MA, US
Vincent DARMENCY - Bougy Villars, CH
Hrvoje LUSIC - Boston MA, US
Kevin J. HODGETTS - Framingham MA, US

International Classification:

C07D 495/04
C07D 487/04
C07D 405/04
C07D 239/42
C07D 239/70
C07D 471/04
C07D 239/84
C07D 251/16
C07D 251/22
C07D 405/10

Abstract:

The present invention relates to 2-amino-4-arylpyrimidine and 2-amino-4-aryltriazine compounds as inhibitors of heat shock protein 90 family of chaperone proteins. The invention also features pharmaceutical compositions and kits that include the compounds and compositions of the invention. The invention further relates to the medical use of these compounds and compositions for the treatment of a disorder hi a subject. For example, the disorder is a neurodegenerative disease.

US Patent:

20210137936, May 13, 2021

Filed:

Sep 25, 2020

Appl. No.:

17/032432

Inventors:

- Cambridge MA, US
- Tokyo, JP
Hyeong Wook CHOI - Andover MA, US
Kristen SANDERS - Gilmanton NH, US
Steven MATHIEU - Andover MA, US
Arani CHANDA - Malden MA, US
Francis FANG - Andover MA, US

International Classification:

A61K 31/5377
C07D 405/12

Abstract:

Provided herein is N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl (tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4′-(morpholinomethyl)-[1,1′-biphenyl]-3-carboxamide hydrobromide. Also provided herein is a particular polymorph form of this compound.

US Patent:

20210017163, Jan 21, 2021

Filed:

Jun 3, 2020

Appl. No.:

16/891427

Inventors:

- Cambridge MA, US
- Tokyo, JP
Steven MATHIEU - Andover MA, US
Kristen SANDERS - Gilmanton NH, US
Arani CHANDA - Malden MA, US

International Classification:

C07D 405/12
A61K 31/5377
C07D 413/12

Abstract:

Provided herein are novel solid forms of N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl (tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4′-(morpholinomethyl)-[1,1′-biphenyl]-3-carboxamide hydrochloride, and related compositions and methods.

US Patent:

20190389878, Dec 26, 2019

Filed:

Jul 1, 2019

Appl. No.:

16/459138

Inventors:

- Cambridge MA, US
- Boston MA, US
Kevin J. HODGETTS - Framingham MA, US
Steven L. MATHIEU - Somerville MA, US
Yukari Y. PERRELLA - Cambridge MA, US
Vincent DARMENCY - Bougy Villars, CH
Hrvoje LUSIC - Boston MA, US

International Classification:

C07D 495/04
C07D 251/16
C07D 251/22
C07D 405/10
C07D 239/84
C07D 471/04
C07D 239/70
C07D 239/42
C07D 405/04
C07D 487/04

Abstract:

The present invention relates to 2-amino-4-arylpyrimidine and 2-amino-4-aryltriazine compounds as inhibitors of heat shock protein 90 family of chaperone proteins. The invention also features pharmaceutical compositions and kits that include the compounds and compositions of the invention. The invention further relates to the medical use of these compounds and compositions for the treatment of a disorder in a subject. For example, the disorder is a neurodegenerative disease.

US Patent:

20190269692, Sep 5, 2019

Filed:

Feb 8, 2019

Appl. No.:

16/270752

Inventors:

- Cambridge MA, US
- Tokyo, JP
Hyeong Wook CHOI - Andover MA, US
Kristen SANDERS - Gilmanton NH, US
Steven MATHIEU - Andover MA, US
Arani CHANDA - Malden MA, US
Francis FANG - Andover MA, US

International Classification:

A61K 31/5377
C07D 405/12

Abstract:

Provided herein is N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl (tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4′-(morpholinomethyl)-[1,1′-biphenyl]-3-carboxamide hydrobromide. Also provided herein is a particular polymorph form of this compound.

US Patent:

20180282312, Oct 4, 2018

Filed:

Jun 5, 2018

Appl. No.:

16/000539

Inventors:

- Cambridge MA, US
- Tokyo, JP
Steven MATHIEU - Andover MA, US
Kristen SANDERS - Gilmanton NH, US
Arani CHANDA - Malden MA, US

Assignee:

Epizyme, Inc. - Cambridge MA
Eisai R&D Management Co., Ltd. - Tokyo

International Classification:

C07D 405/12
A61K 31/5377
C07D 413/12

Abstract:

Provided herein are novel solid forms of N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl (tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4′-(morpholinomethyl)-[1,1′-biphenyl]-3-carboxamide hydrochloride, and related compositions and methods.