Matthew R. Redinbo - Chapel Hill NC, US Scott Lujan - Chapel Hill NC, US Steven W. Matson - Chapel Hill NC, US
International Classification:
A61K 31/665 C12Q 1/68
US Classification:
514 99, 435 6
Abstract:
Methods of treating a microbial infection in a subject by administering to the subject an effective amount of a compound that modulates an enzymatic activity of a relaxase polypeptide is provided. Methods of inhibiting bacterial conjugation by modulating activity of a relaxase polypeptide in a bacterium are also provided. Novel compounds that modulate relaxase enzymes and assays for measuring kinetics of relaxase enzymes and selecting for modulators of relaxase enzyme activity are further provided.