Steven M Mccormick

US Patent:

7132279, Nov 7, 2006

Filed:

Jul 26, 2005

Appl. No.:

11/190631

Inventors:

Dan-Ning Hu - Bayside NY, US
Steven McCormick - New York NY, US

Assignee:

New York Eye & Ear Infirmary - New York NY

International Classification:

C12N 5/00
C12N 5/02
A01N 63/00
A01N 65/00

US Classification:

435325, 435405, 435408

Abstract:

The present invention provides methods and compositions for providing graft recipients with epidermal melanocytes. Specifically, the methods and compositions of the invention provide for populations of epidermal melanocytes that may be isolated from a patient and cultured in vitro to generate a proliferating population of epidermal melanocytes that exhibit growth, migration and melanin production. The invention is based on the discovery of a culture medium composed of natural components, for culturing epidermal melanocytes that exhibit increased proliferative capacity, migratory behaviors and melanin production. The invention provides novel in vitro methods for culturing epidermal melanocytes, including those isolated from the skin of a healthy subject, to generate a proliferating population of epidermal melanocytes. The methods and compositions of the invention may be used for transplantation to treat patients having hypopigmentation or depigmentation skin disorders.

US Patent:

20040176752, Sep 9, 2004

Filed:

Mar 6, 2003

Appl. No.:

10/383124

Inventors:

Robert Alfano - Bronx NY, US
Tapan Gayen - Brooklyn NY, US
Steven McCormick - New York NY, US
Richard Rosen - New York NY, US
Alvin Katz - Bronx NY, US
Howard Savage - Ossining NY, US

International Classification:

A61B018/20

US Classification:

606/004000, 606/008000

Abstract:

A system and method for exposing ocular tissue to a beam of electromagnetic radiation tuned to an NIR wavelength between about 1380 nm and about 1600 nm in the water absorption band. The laser energy is absorbed by the water, which in turn, transfers the energy to collagen molecules. The helical collagen molecules partially denature and then re-nature to form a weld across the region of the tissues to be joined. In a preferred embodiment, the electromagnetic radiation originates from a laser. The lasers may be Cr doped crystals, Erbium fibers, and alloys of semiconductor laser diodes.

US Patent:

20050064588, Mar 24, 2005

Filed:

Sep 24, 2003

Appl. No.:

10/670971

Inventors:

Dan-Ning Hu - Bayside NY, US
Steven McCormick - New York NY, US

International Classification:

C12N005/08
C12N005/02

US Classification:

435366000, 435404000

Abstract:

The present invention provides methods and compositions for providing graft recipients with epidermal melanocytes. Specifically, the methods and compositions of the invention provide for populations of epidermal melanocytes that may be isolated from a patient and cultured in vitro to generate a proliferating population of epidermal melanocytes that exhibit growth, migration and melanin production. The invention is based on the discovery of a culture medium composed of natural components, for culturing epidermal melanocytes that exhibit increased proliferative capacity, migratory behaviors and melanin production. The invention provides novel in vitro methods for culturing epidermal melanocytes, including those isolated from the skin of a healthy subject, to generate a proliferating population of epidermal melanocytes. The methods and compositions of the invention may be used for transplantation to treat patients having hypopigmentation or depigmentation skin disorders.

US Patent:

20070178074, Aug 2, 2007

Filed:

Oct 6, 2006

Appl. No.:

11/539464

Inventors:

Dan-Ning Hu - Bayside NY, US
Steven McCormick - New York NY, US

International Classification:

A61K 35/12
C12N 5/08
C12N 5/06

US Classification:

424093700, 435325000, 435366000

Abstract:

The present invention provides methods and compositions for providing graft recipients with chondrocytes. Specifically, the methods and compositions of the invention provide for populations of chondrocytes that may be isolated from a patient and cultured in vitro to generate a proliferating population of chondrocytes that exhibit great proliferation capacity. The invention is based, in part, on the discovery of a culture medium having serum, insulin and various growth factors for culturing chondrocytes that exhibit increased proliferative capacity. The invention provides novel in vitro methods for culturing chondrocytes, including those isolated from the cartilage of a healthy subject, to generate a proliferating population of chondrocytes. The methods and compositions of the invention may be used for transplantation to treat patients having damaged cartilage.