Steven E Read

US Patent:

8232386, Jul 31, 2012

Filed:

Oct 27, 2011

Appl. No.:

13/317752

Inventors:

Anastasia Khvorova - Northborough MA, US
Angela Reynolds - Littleton CO, US
Devin Leake - Denver CO, US
William Marshall - Boulder CO, US
Steven Read - Denver CO, US
Stephen Scaringe - Lafayette CO, US

Assignee:

Dharmacon, Inc. - Lafayette CO

International Classification:

C07H 21/04
C07H 21/02
A61K 48/00

US Classification:

536 245, 536 231, 514 44

Abstract:

Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for APOB.

US Patent:

8234695, Jul 31, 2012

Filed:

Dec 21, 2007

Appl. No.:

11/962560

Inventors:

Alan D. Eldridge - Hollis NH, US
Phillipe A. Loher - Lowell MA, US
Peter O. Mierswa - Sterling MA, US
Steven E. Read - Berlin MA, US

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

G06F 21/00

US Classification:

726 5, 726 4, 726 7, 726 19, 713183, 380255, 709223, 705 30, 455411

Abstract:

A method of managing network security can include receiving a user input comprising a user name and a password, determining whether the input user name potentially corresponds to a plurality of user accounts, determining whether the password is valid, and determining whether each of the user accounts is locked. The method can include selecting a security response to the user input based upon whether the input user name potentially corresponds to the plurality of user accounts, whether the password is valid, whether each of the user accounts is locked, and outputting the security response.

US Patent:

8399654, Mar 19, 2013

Filed:

May 8, 2012

Appl. No.:

13/466631

Inventors:

Anastasia Khvorova - Northborough MA, US
Angela Reynolds - Conifer CO, US
Devin Leake - Denver CO, US
William Marshall - Boulder CO, US
Steven Read - Denver CO, US
Stephen Scaringe - Lafayette CO, US

Assignee:

Dharmacon, Inc. - Lafayette CO

International Classification:

C07H 21/02
C07H 21/04
C12Q 1/68
C12P 19/34

US Classification:

536 245, 435 6, 435 911, 435 9131, 536 231, 536 243

Abstract:

Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for CTNNB1.

US Patent:

8445667, May 21, 2013

Filed:

Jun 25, 2012

Appl. No.:

13/531657

Inventors:

Anastasia Khvorova - Northborough MA, US
Angela Reynolds - Conifer CO, US
Devin Leake - Denver CO, US
William Marshall - Boulder CO, US
Steven Read - Denver CO, US
Stephen Scaringe - Lafayette CO, US

Assignee:

Dharmacon, Inc. - Lafayette CO

International Classification:

C07H 21/04
C07H 21/02

US Classification:

536 245, 536 231

Abstract:

Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for CDKN1B.

US Patent:

8445668, May 21, 2013

Filed:

Jun 28, 2012

Appl. No.:

13/536005

Inventors:

Anastasia Khvorova - Northborough MA, US
Angela Reynolds - Conifer CO, US
Devin Leake - Denver CO, US
William Marshall - Boulder CO, US
Steven Read - Denver CO, US
Stephen Scaringe - Lafayette CO, US

Assignee:

Dharmacon, Inc. - Lafayette CO

International Classification:

C07H 21/04
C07H 21/02

US Classification:

536 245, 536 231

Abstract:

Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for APOB.

US Patent:

8575329, Nov 5, 2013

Filed:

Jun 15, 2012

Appl. No.:

13/524015

Inventors:

Anastasia Khvorova - Northborough MA, US
Angela Reynolds - Conifer CO, US
Devin Leake - Denver CO, US
William Marshall - Boulder CO, US
Steven Read - Denver CO, US
Stephen Scaringe - Lafayette CO, US

Assignee:

Thermo Fisher Scientific Biosciences Inc. - Lafayette CO

International Classification:

C07H 21/02
C07H 21/04
C12Q 1/68

US Classification:

536 245, 536 231, 536 241

Abstract:

Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for KDR.

US Patent:

20120210410, Aug 16, 2012

Filed:

Apr 23, 2012

Appl. No.:

13/453294

Inventors:

ALAN D. ELDRIDGE - HOLLIS NH, US
PHILLIPE A. LOHER - LOWELL MA, US
PETER O. MIERSWA - STERLING MA, US
STEVEN E. READ - BERLIN MA, US

Assignee:

INTERNATIONAL BUSINESS MACHINES CORPORATION - ARMONK NY

International Classification:

G06F 21/00

US Classification:

726 7

Abstract:

A method of managing network security can include receiving a user input comprising a user name and a password, determining whether the input user name potentially corresponds to a plurality of user accounts, determining whether the password is valid, and determining whether each of the user accounts is locked. The method can include selecting a security response to the user input based upon whether the input user name potentially corresponds to the plurality of user accounts, whether the password is valid, whether each of the user accounts is locked, and outputting the security response.

US Patent:

20120252873, Oct 4, 2012

Filed:

Jun 6, 2012

Appl. No.:

13/489725

Inventors:

Anastasia Khvorova - Northborough MA, US
Angela Reynolds - Conifer CO, US
Devin Leake - Denver CO, US
William Marshall - Boulder CO, US
Steven Read - Denver CO, US
Stephen Scaringe - Lafayette CO, US

Assignee:

DHARMACON, INC. - Lafayette CO

International Classification:

C07H 21/02
C12N 15/113
C12N 5/071
C40B 40/06
A61K 31/713

US Classification:

514 44 A, 536 245, 506 16, 435375

Abstract:

Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for IRAK4.