Steven A Shafer

US Patent:

20060252786, Nov 9, 2006

Filed:

Oct 20, 2005

Appl. No.:

11/255002

Inventors:

Pamela Flood - Closter NJ, US
Steven Shafer - Palo Alto CA, US

Assignee:

The Trustees of Columbia University - New York NY

International Classification:

A61K 31/485
A61K 31/4439
A61K 31/445
A61K 31/22
A61K 31/14

US Classification:

514282000, 514343000, 514546000, 514642000, 514317000

Abstract:

This invention provides two methods for reducing, or inhibiting the onset of, pain in a subject. The first method for reducing, or inhibiting the onset of, pain in a subject comprises administering to the subject (a) a nicotinic receptor agonist, and (b) an opioid receptor agonist; wherein the ratio of nicotinic receptor agonist to opioid receptor agonist administered to the subject is less than 3:4 and greater than 1:100. The second method for reducing, or inhibiting the onset of, pain in a subject comprises administering to the subject (a) a nicotinic receptor agonist at a rate of less than 3 mg per three hour period; and (b) an opioid receptor agonist at a rate of less than 4 mg per three hour period. This invention also provides two compositions, a transdermal patch, and an article of manufacture for practicing the instant methods.

US Patent:

20100179854, Jul 15, 2010

Filed:

Jan 14, 2010

Appl. No.:

12/687562

Inventors:

Steven L. Shafer - Closter NJ, US
Thomas J. Shafer - Mountain View CA, US
Nathan Esquenazi - Irvine CA, US

International Classification:

G06Q 10/00
G06Q 50/00
A61B 5/00
G06F 15/16

US Classification:

705 9, 600301, 709206, 709204

Abstract:

A system for scheduling an appointment between a client and a provider including a monitoring and validation component that includes a transaction database, a validation engine and at least one transaction monitoring rule, and an Internet-based scheduling component the populates the transaction database, wherein the validation engine is configured to apply the transaction monitoring rules to the transaction database to identify the presence of exceptional transactions in the transaction database.