Steven Scott Sutton

US Patent:

6347109, Feb 12, 2002

Filed:

Jan 25, 1999

Appl. No.:

09/237142

Inventors:

Raymond J. Beach - Livermore CA
Eric C. Honea - Sunol CA
Camille Bibeau - Dublin CA
Stephen A. Payne - Castro Valley CA
Howard Powell - Livermore CA
William F. Krupke - Pleasanton CA
Steven B. Sutton - Manteca CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

H01S 03933

US Classification:

372 75, 372 36, 372 67

Abstract:

Using a thin disk laser gain element with an undoped cap layer enables the scaling of lasers to extremely high average output power values. Ordinarily, the power scaling of such thin disk lasers is limited by the deleterious effects of amplified spontaneous emission. By using an undoped cap layer diffusion bonded to the thin disk, the onset of amplified spontaneous emission does not occur as readily as if no cap layer is used, and much larger transverse thin disks can be effectively used as laser gain elements. This invention can be used as a high average power laser for material processing applications as well as for weapon and air defense applications.

US Patent:

6951882, Oct 4, 2005

Filed:

Dec 12, 2003

Appl. No.:

10/734800

Inventors:

Nicholas I Carruthers - Poway CA, US
Todd K. Jones - Solana Beach CA, US
Xiaobing Li - Flemington NJ, US
Timothy W. Lovenberg - San Diego CA, US
Laura C. McAtee - King of Prussia PA, US
Victor K. Phuong - San Diego CA, US
Dale A. Rudolph - San Diego CA, US
Steven W. Sutton - Carlsbad CA, US

Assignee:

Janssen Pharmaceutica N.V.

International Classification:

A61K031/357
C07D319/06

US Classification:

514452, 514314, 514444, 546173, 549 59, 549371

Abstract:

Urea-containing, substituted 4-phenyl-[1,3]-dioxanes, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, obesity or a sleep/wake disorder mediated by orexin-2 are described.

US Patent:

7618786, Nov 17, 2009

Filed:

Dec 11, 2003

Appl. No.:

10/537732

Inventors:

Steven W. Sutton - Carlsbad CA, US
Timothy W. Lovenberg - San Diego CA, US

Assignee:

Janssen Pharmaceutica N.V. - Beerse

International Classification:

G01N 33/53
G01N 33/566
G01N 33/567
C12N 15/85
C12N 5/08

US Classification:

435 71, 435 72, 435 721, 435 723, 435325, 435366, 435371, 436501

Abstract:

The present invention provides a new method for identifying modulators of human orexin-2 receptor without utilizing recombinantly produced nucleic acid molecules encoding human orexin receptor protein. This method combines and utilizes known methods and cell lines selected for their natural expression of orexin-2 receptors to carry out the methods of the present invention. Exemplary methods of the present invention utilize PFSK-1 cells to produce non-recombinant human orexin-2 receptor protein.

US Patent:

7893197, Feb 22, 2011

Filed:

Aug 25, 2005

Appl. No.:

11/660883

Inventors:

Pascal Bonaventure - San Diego CA, US
Chester Kuei - San Diego CA, US
Changlu Liu - San Diego CA, US
Timothy W. Lovenberg - San Diego CA, US
Steven W. Sutton - Carlsbad CA, US

Assignee:

Janssen Pharmaceutica N.V. - Beerse

International Classification:

A61K 38/00
C07K 14/64

US Classification:

530300, 530325, 530350

Abstract:

Chimeric polypeptides of relaxin-3, prepropolypeptides thereof, polynucleotides encoding such polypeptides, and associated expression vectors and host cells are described. The polypeptides may be used to prepare receptor-ligand complexes with GPCR135 or GPCR142, which may be used in assay methods.

US Patent:

8299028, Oct 30, 2012

Filed:

Jan 23, 2008

Appl. No.:

12/449137

Inventors:

Chester Kuei - San Diego CA, US
Changlu Liu - San Diego CA, US
Cindy M. Pudiak - Binghamton NY, US
Jonathan Edward Shelton - San Marcos CA, US
Steven W. Sutton - Carlsbad CA, US

Assignee:

Janssen Pharmaceutica NV - Beerse

International Classification:

A61K 38/22
C07K 14/64

US Classification:

514 127, 514 206, 514 213

Abstract:

The chimeric polypeptide R3(BΔ23-27)R/I5 is described, which is a high-affinity antagonist for GPCR1 35 and GPCR1 42 over LGR7.

US Patent:

59369841, Aug 10, 1999

Filed:

Apr 21, 1998

Appl. No.:

9/063873

Inventors:

Helmuth E. Meissner - Pleasanton CA
Raymond J. Beach - Livermore CA
Camille Bibeau - Danville CA
Steven B. Sutton - Manteca CA
Scott Mitchell - Tracy CA
Isaac Bass - Castro Valley CA
Eric Honea - Sunol CA

Assignee:

Onxy Optics, Inc. - Dublin CA
United States Enrichment Corporation - Bethesda MD

International Classification:

H01S 304

US Classification:

372 34

Abstract:

A method and apparatus for achieving improved performance in a solid state laser is provided. A flanged, at least partially undoped end-cap is attached to at least one end of a laserable medium. Preferably flanged, undoped end-caps are attached to both ends of the laserable medium. Due to the low scatter requirements for the interface between the end-caps and the laser rod, a non-adhesive method of bonding is utilized such as optical contacting combined with a subsequent heat treatment of the optically contacted composite. The non-bonded end surfaces of the flanged end-caps are coated with laser cavity coatings appropriate for the lasing wavelength of the laser rod. A cooling jacket, sealably coupled to the flanged end-caps, surrounds the entire length of the laserable medium. Radiation from a pump source is focussed by a lens duct and passed through at least one flanged end-cap into the laser rod.

US Patent:

53053451, Apr 19, 1994

Filed:

Sep 25, 1992

Appl. No.:

7/950559

Inventors:

Georg F. Albrecht - Livermore CA
Brian Comaskey - Stockton CA
Steven B. Sutton - Manteca CA

Assignee:

The United States of America as represented by the United States
Department of Energy - Washington DC

International Classification:

H01S 309

US Classification:

372 69

Abstract:

The architecture of the present invention has been driven by the need to solve the beam quality problems inherent in Brewster's angle tipped slab lasers. The entrance and exit faces of a solid state slab laser are cut perpendicular with respect to the pump face, thus intrinsically eliminating distortion caused by the unpumped Brewster's angled faces. For a given zigzag angle, the residual distortions inherent in the remaining unpumped or lightly pumped ends may be reduced further by tailoring the pump intensity at these ends.

US Patent:

55263720, Jun 11, 1996

Filed:

Aug 5, 1994

Appl. No.:

8/286372

Inventors:

Georg Albrecht - Livermore CA
E. Victor George - Livermore CA
William F. Krupke - Pleasanton CA
Walter Sooy - Pleasanton CA
Steven B. Sutton - Manteca CA

Assignee:

The United States of America as represented by the United States
Department of Energy - Washington DC

International Classification:

H01S 304

US Classification:

372 69

Abstract:

High energy bursts are produced from a solid state laser operated in a heat capacity limited regime. Instead of cooling the laser, the active medium is thermally well isolated. As a result, the active medium will heat up until it reaches some maximum acceptable temperature. The waste heat is stored in the active medium itself. Therefore, the amount of energy the laser can put out during operation is proportional to its mass, the heat capacity of the active medium, and the temperature difference over which it is being operated. The high energy burst capacity of a heat capacity operated solid state laser, together with the absence of a heavy, power consuming steady state cooling system for the active medium, will make a variety of applications possible. Alternately, cooling takes place during a separate sequence when the laser is not operating. Industrial applications include new material working processes.