The present invention provides a new method for identifying modulators of human orexin-2 receptor without utilizing recombinantly produced nucleic acid molecules encoding human orexin receptor protein. This method combines and utilizes known methods and cell lines selected for their natural expression of orexin-2 receptors to carry out the methods of the present invention. Exemplary methods of the present invention utilize PFSK-1 cells to produce non-recombinant human orexin-2 receptor protein.
Complexes Of Gpcr142 And Relaxin3 Or Insl5, And Their Production And Use
Chester Kuei - Murrieta CA, US Changlu Liu - San Diego CA, US Timothy Lovenberg - San Diego CA, US Steven Sutton - Carlsbad CA, US Jingcai Chen - Beijing, CN
International Classification:
C12Q001/68 G01N033/53 C07K014/705
US Classification:
435007100, 530350000
Abstract:
A GPCR142/relaxin3 and GPCR142/INSL5 complexes are described. The complexes are useful as assay reagents for screening for modulators of GPCR142 receptor activity.
Relaxin3-Gpcr135 Complexes And Their Production And Use
Jingcai Chen - Beijing, CN Chester Kuei - Murrieta CA, US Changlu Liu - San Diego CA, US Timothy Lovenberg - San Diego CA, US Rannar Sillard - Stockholm, SE Steven Sutton - Carlsbad CA, US
International Classification:
G01N033/53 G06F019/00 G01N033/48 G01N033/50
US Classification:
435007100, 530350000, 702019000
Abstract:
A GPCR135/relaxin3 complex is described, which is useful as an assay reagent for screening for modulators of GPCR135 receptor activity.
Relaxin3-Gpcr135 Complexes And Their Production And Use
Jingcai Chen - Beijing, CN Chester Kuei - Murrieta CA, US Changlu Liu - San Diego CA, US Timothy Lovenberg - San Diego CA, US Rannar Sillard - Stockholm, SE Steven Sutton - Carlsbad CA, US
- Carlsbad CA, US Matthew Myers - Carlsbad CA, US Wee Joung Kim - Vista CA, US Steven C. Sutton - Carlsbad CA, US Larry Tang - Carlsbad CA, US Denver Holt - Carlsbad CA, US
International Classification:
A63B 53/06 A63B 53/04 A63B 60/52 A63B 60/04
Abstract:
A golf club head comprising multiple means of adjusting the location of the center of gravity, and the bias, is disclosed herein. In a preferred embodiment, the golf club head comprises a non-metal medallion comprising a channel that is affixed to one of the crown and the sole, a slidable weight sized to fit within the channel, and a cover that attaches to the medallion and locks the slidable weight within the channel at a location selected by a user. The cover preferably includes at least one cutout so that the slidable weight is at least partially visible to the user when it is locked within the channel. The cover also includes additional cutouts that receive protrusions extending from the medallion to more securely attach the cover to the medallion.
- Carlsbad CA, US Denver Holt - Carlsbad CA, US James A. Seluga - Carlsbad CA, US Wee Joung Kim - Vista CA, US Steven C. Sutton - Carlsbad CA, US
International Classification:
A63B 53/06 A63B 53/04
Abstract:
A golf club head comprising a slidable weight for adjusting the location of the golf club head center of gravity, as well as the golf club head bias, is disclosed herein. In particular, the golf club head, which may be a wood or iron-type head, comprises a pair of rails extending along at least one surface, such as a rear surface of an iron type head or a channel disposed in a wood-type head, and a slidable weight comprising a pair of grooves sized to receive the rails. In some embodiments, an applique or one or more clips are applied over or to the rails to prevent the weight from disengaging from the golf club head.
- Carlsbad CA, US Matthew Myers - Carlsbad CA, US Wee Joung Kim - Vista CA, US Steven C. Sutton - Carlsbad CA, US Larry Tang - Carlsbad CA, US Denver Holt - Carlsbad CA, US
International Classification:
A63B 53/04
Abstract:
A golf club head comprising multiple means of adjusting the location of the center of gravity, and the bias, is disclosed herein. In a preferred embodiment, the golf club head comprises a non-metal medallion comprising a channel that is affixed to one of the crown and the sole, a slidable weight sized to fit within the channel, and a cover that attaches to the medallion and locks the slidable weight within the channel at a location selected by a user. The cover preferably includes at least one cutout so that the slidable weight is at least partially visible to the user when it is locked within the channel. The cover also includes additional cutouts that receive protrusions extending from the medallion to more securely attach the cover to the medallion.
Dr. Sutton graduated from the University of Texas Southwestern Medical Center at Dallas in 1998. He works in Cincinnati, OH and specializes in Allergy & Immunology.
Bridging The Gaps 423 W Cork St, Winchester, VA 22601 5405351111 (phone), 5404501205 (fax)
Education:
Medical School East Carolina University Brody School Medicine Graduated: 1991
Conditions:
Substance Abuse and/or Dependency
Languages:
English
Description:
Dr. Sutton graduated from the East Carolina University Brody School Medicine in 1991. He works in Winchester, VA and specializes in Addiction Medicine and Family Medicine.