Steven Lou Walker

US Patent:

20140080788, Mar 20, 2014

Filed:

Apr 27, 2012

Appl. No.:

14/113593

Inventors:

Jeffrey A. Robl - Newtown PA, US
Jun Li - Princeton NJ, US
Lawrence J. Kennedy - Titusville NJ, US
Steven J. Walker - Pennington NJ, US
Haixia Wang - Columbus NJ, US
William N. Washburn - Titusville NJ, US
Saleem Ahmad - Wall NJ, US
Khehyong Ngu - Pennington NJ, US

International Classification:

C07D 401/04
A61K 45/06
C07D 215/08
A61K 31/47
A61K 31/473
C07D 221/16
C07D 413/04
A61K 31/5377
C07D 403/04
A61K 31/55
A61K 31/553
C07D 417/04
A61K 31/496
C07D 401/12
C07D 401/14
A61K 31/506
C07D 405/14
C07D 409/14
C07F 9/60
A61K 31/675
A61K 31/5415
A61K 31/4747
A61K 31/554
A61K 31/4709

US Classification:

514 82, 546165, 514314, 514311, 546 79, 514290, 544105, 5142305, 540593, 51421301, 540552, 51421109, 544363, 51425306, 51421018, 544331, 514275, 540543, 546 23, 544 52, 5142242, 546 18, 514278

Abstract:

Novel compounds of Formula I:or an enantiomer, diastereomer, tautomer, prodrug or salt thereof, wherein m, Q, T, U, V, ring A, X, Y, R, R, R, R, R, R, R, R, R, R, and Rare defined herein, are provided which are TGR5 G protein-coupled receptor modulators. TGR5 G protein-coupled receptor modulators are useful in treating, preventing, or slowing the progression of diseases requiring TGR5 G protein-coupled receptor modulator therapy. Thus, the disclosure also concerns compositions comprising these novel compounds and methods of treating diseases or conditions related to the activity of the TGR5 G protein-coupled receptor by using any of these novel compounds or a composition comprising any of such novel compounds.