Steven T Walker

US Patent:

7117455, Oct 3, 2006

Filed:

Jul 24, 2003

Appl. No.:

10/626762

Inventors:

Steven G. Walker - Chappaqua NY, US
Chandramouli Visweswariah - Croton-on-Hudson NY, US
Katya Scheinberg - New York NY, US
Phillip Restle - Katonah NY, US

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

G06F 17/50

US Classification:

716 2, 703 2

Abstract:

The present invention is a system and method for optimizing electrical circuits by means of derivative-free optimization. Tunable parameters such as component values, transistor sizes or model parameters are automatically adjusted to obtain an optimal circuit. Any method of measuring the performance of the circuit, including computer simulation, can be incorporated into the optimization technique, with no derivative requirements. An arbitrary continuous optimization problem can be posed, including an objective function, equality and inequality constraints, and simple bounds on the tunable parameters. The optimization technique is efficient and guarantees that it will find a locally optimal solution from any starting point. Further, the procedure includes a method of automatically recovering from electrical failure to enable automatic and productive circuit optimization. A set of measurement widgets is provided to automatically introduce the checking required to recover from electrical failure.

US Patent:

7519526, Apr 14, 2009

Filed:

Feb 16, 2006

Appl. No.:

11/355342

Inventors:

Emrah Acar - Montvale NJ, US
Bhavna Agrawal - Ennetbaden, CH
Peter Feldmann - New York NY, US
Ying Liu - Austin TX, US
Steven G. Walker - Pleasantville NY, US

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

G06F 17/50

US Classification:

703 14

Abstract:

A solution for analyzing a circuit using initial charge information is provided. In particular, one or more nodes in a design for the circuit is initialized with an initial charge. The charge can comprise a non-equilibrium charge, thereby simulating the history effect, the impact of a charged particle, electro-static discharge (ESD), and/or the like. Operation of the circuit is then simulated over the set of input cycles based on the initial charge(s). To this extent, the non-equilibrium initial condition solution enables the state of the circuit to be controlled and solves the initial system based on these values. This capability is very useful to condition the circuit at a worst-case, best-case, and/or the like, status. Further, in one embodiment of the invention, a set of equations are provided to implement the non-equilibrium initial charge analysis, which provide a more efficient initialization of the circuit than current solutions.

US Patent:

8290760, Oct 16, 2012

Filed:

Jun 27, 2008

Appl. No.:

12/163318

Inventors:

Emrah Acar - Montvale NJ, US
Bhavna Agrawal - Ennetbaden, CH
Peter Feldmann - New York NY, US
Ying Liu - Austin TX, US
Steven G. Walker - Pleasantville NY, US

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

G06F 17/50

US Classification:

703 14, 703 2

Abstract:

A solution for analyzing a circuit using initial charge information is provided. In particular, one or more nodes in a design for the circuit is initialized with an initial charge. The charge can comprise a non-equilibrium charge, thereby simulating the history effect, the impact of a charged particle, electro-static discharge (ESD), and/or the like. Operation of the circuit is then simulated over a set of input cycles based on the initial charge(s). To this extent, the non-equilibrium initial condition solution enables the state of the circuit to be controlled and solves the initial system based on these values. This capability is very useful to condition the circuit at a worst-case, best-case, and/or the like, status. Further, in one embodiment of the invention, a set of equations are provided to implement the non-equilibrium initial charge analysis, which provide a more efficient initialization of the circuit than current solutions.

US Patent:

20140080788, Mar 20, 2014

Filed:

Apr 27, 2012

Appl. No.:

14/113593

Inventors:

Jeffrey A. Robl - Newtown PA, US
Jun Li - Princeton NJ, US
Lawrence J. Kennedy - Titusville NJ, US
Steven J. Walker - Pennington NJ, US
Haixia Wang - Columbus NJ, US
William N. Washburn - Titusville NJ, US
Saleem Ahmad - Wall NJ, US
Khehyong Ngu - Pennington NJ, US

International Classification:

C07D 401/04
A61K 45/06
C07D 215/08
A61K 31/47
A61K 31/473
C07D 221/16
C07D 413/04
A61K 31/5377
C07D 403/04
A61K 31/55
A61K 31/553
C07D 417/04
A61K 31/496
C07D 401/12
C07D 401/14
A61K 31/506
C07D 405/14
C07D 409/14
C07F 9/60
A61K 31/675
A61K 31/5415
A61K 31/4747
A61K 31/554
A61K 31/4709

US Classification:

514 82, 546165, 514314, 514311, 546 79, 514290, 544105, 5142305, 540593, 51421301, 540552, 51421109, 544363, 51425306, 51421018, 544331, 514275, 540543, 546 23, 544 52, 5142242, 546 18, 514278

Abstract:

Novel compounds of Formula I:or an enantiomer, diastereomer, tautomer, prodrug or salt thereof, wherein m, Q, T, U, V, ring A, X, Y, R, R, R, R, R, R, R, R, R, R, and Rare defined herein, are provided which are TGR5 G protein-coupled receptor modulators. TGR5 G protein-coupled receptor modulators are useful in treating, preventing, or slowing the progression of diseases requiring TGR5 G protein-coupled receptor modulator therapy. Thus, the disclosure also concerns compositions comprising these novel compounds and methods of treating diseases or conditions related to the activity of the TGR5 G protein-coupled receptor by using any of these novel compounds or a composition comprising any of such novel compounds.

US Patent:

20180333395, Nov 22, 2018

Filed:

Jul 18, 2018

Appl. No.:

16/038739

Inventors:

Peter Tai Wah Cheng - Princeton NJ, US
Jun Li - Princeton NJ, US
Jun Shi - Pennington NJ, US
Yan Shi - Flourtown PA, US
Shiwei Tao - Hillsborough NJ, US
Hao Zhang - Belle Mead NJ, US
Suresh Dhanusu - Hosur Tamil Nadu, IN
Kumaravel Selvakumar - Bangalore, IN
Ramesh Babu Reddigunta - Chittoor District, IN
Steven J. Walker - Pennington NJ, US
Lawrence J. Kennedy - Titusville NJ, US
James R. Corte - Yardley PA, US
Tianan Fang - Newtown PA, US
Sutjano Jusuf - Princeton NJ, US

International Classification:

A61K 31/4192
C07D 249/06
C07D 401/14
C07D 401/04
A61K 31/27
A61K 31/454

Abstract:

The present invention provides compounds of Formula (I):or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

US Patent:

20170360759, Dec 21, 2017

Filed:

Jun 20, 2017

Appl. No.:

15/628104

Inventors:

- Princeton NJ, US
Jun LI - Princeton NJ, US
Jun Shi - Pennington NJ, US
Yan Shi - Flourtown PA, US
Shiwei Tao - Hillsborough NJ, US
Hao Zhang - Belle Mead NJ, US
Suresh Dhanusu - Hosur, IN
Kumaravel Selvakumar - Bangalore, IN
Ramesh Babu Reddigunta - Chittoor District, IN
Steven J. Walker - Pennington NJ, US
Lawrence J. Kennedy - Titusville NJ, US
James R. Corte - Yardley PA, US
Tianan Fang - Newtown PA, US
Sutjano Jusuf - Princeton NJ, US

International Classification:

A61K 31/4192
A61K 31/27
C07D 401/04
A61K 31/454
C07C 62/10
A61K 31/41

Abstract:

The present invention provides compounds of Formula (I):or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.