Stewart S Levine

US Patent:

7135303, Nov 14, 2006

Filed:

Feb 28, 2001

Appl. No.:

10/220443

Inventors:

Stewart Levine - North Potomac MD, US

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

G01N 33/53
C12Q 1/68
C12P 21/02
A61K 48/00
C12N 5/06

US Classification:

435 772, 6 71, 6 691, 63201, 6325, 514 44, 530350, 536 235

Abstract:

The present invention provides compositions and methods for the regulation of cytokine signaling through the Tumor Necrosis Factor (TNF) pathway. Specifically, the invention provides a novel gene, polypeptide and related compositions and methods for the regulation of ectodomain shedding. In preferred embodiments, methods and compositions for the regulation of TNF Type-1 Receptor ectodomain shedding are provided. The present invention finds use in therapeutics, diagnostics, and drug screening applications.

US Patent:

7655752, Feb 2, 2010

Filed:

Mar 24, 2006

Appl. No.:

11/389675

Inventors:

Stewart J. Levine - North Potomac MD, US
Caitriona A. Buckley - Potomac MD, US
Farshid N. Rouhani - Germantown MD, US
Maryann Kaler - Bethesda MD, US

Assignee:

The United States of America as represented by the Secretary of the Department of Health and Human Services - Washington DC

International Classification:

A61K 38/00
C07L 2/00
C07K 4/00
C07K 5/00
C07K 7/00
C07K 14/00
C07K 16/00
C07K 17/00

US Classification:

530300, 514 12, 514 13, 514 16

Abstract:

The invention provides peptides, variants of peptides, peptide fragments, and peptidomimetics that can inhibit the protease activity of tumor necrosis factor alpha converting enzyme. The invention also provides coupled proteins containing a partner protein coupled to a peptide, peptide fragment, or peptidomimetic. The invention also provides polyproteins containing at least two peptides, peptide fragments, or coupled proteins that are connected through a linker. Isolated nucleic acid segments, expression cassettes, and nucleic acid constructs are also provided by the invention. The invention also provides antibodies and aptamers. Pharmaceutical compositions are provided by the invention. Methods to lower or increase levels of active tumor necrosis factor alpha in a mammal are also provided.

US Patent:

20070059758, Mar 15, 2007

Filed:

Nov 13, 2006

Appl. No.:

11/598473

Inventors:

Stewart Levine - North Potomac MD, US

Assignee:

THE GOVERNMENT OF THE USA OF AMERICA, REP. BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES - Rockville MD

International Classification:

C12Q 1/68
C07H 21/04
C12P 21/06
C07K 14/715
C07K 16/28

US Classification:

435006000, 435069100, 435320100, 435325000, 530350000, 536023500, 530388220

Abstract:

The present invention provides compositions and methods for the regulation of cytokine signaling through the Tumor Necrosis Factor (TNF) pathway. Specifically, the invention provides a novel gene, polypeptide and related compositions and methods for the regulation of ectodomain shedding. In preferred embodiments, methods and compositions for the regulation of TNF Type-1 Receptor ectodomain shedding are provided. The present invention finds use in therapeutics, diagnostics, and drug screening applications.

US Patent:

42035511, May 20, 1980

Filed:

Aug 31, 1978

Appl. No.:

5/938633

Inventors:

Stewart A. Levine - Somerville NJ

International Classification:

B65N 7500

US Classification:

239195

Abstract:

An apparatus for non-electrically producing a pulsating spray of water which may be directed to various body cavities as well as any other selected portions of the body. The apparatus is utilized in conjunction with a water supply system and is connected thereto in such a way as to not interfere with the normal flow of water through said water supply system. A flexible tube is utilized for communicating water from said water supply system to a tip for facilitating the aiming of a pulsating spray of water at any desired portion of a body.