Su Hwa Chen

US Patent:

7993931, Aug 9, 2011

Filed:

Oct 28, 2003

Appl. No.:

10/696051

Inventors:

Su Chen - Aliso Viejo CA, US

Assignee:

Quest Diagnostics Investments Incorporated - Wilmington DE

International Classification:

G01N 33/00

US Classification:

436129, 436127, 436173

Abstract:

Provided are methods and compositions for quantitatively measuring the amount of an unlabeled organic acid in a sample. Oxygen-18 labeled organic acids are used as internal standards to adjust for the loss of a structurally similar or identical unlabeled organic acid through processing required for its detection, such as by mass spectrometry. The methods of the invention are useful for diagnosing inborn errors of metabolism in an individual by quantitating signature organic acids in body fluids such as urine or plasma.

US Patent:

20050158835, Jul 21, 2005

Filed:

Jan 21, 2004

Appl. No.:

10/762657

Inventors:

Su Chen - Aliso Viejo CA, US
Hung Kwong - Aliso Viejo CA, US

International Classification:

A61K031/685
C12P007/64

US Classification:

435134000, 514078000, 554078000

Abstract:

Preparation of highly polyunsaturated fatty acid-containing phosphatidylserine and phosphatidic acid by phospholipase D-catalyzed transphosphatidylation of fish liver phosphatidylcholine is disclosed.

US Patent:

20080145902, Jun 19, 2008

Filed:

Feb 15, 2008

Appl. No.:

12/032164

Inventors:

Su Chen - Aliso Viejo CA, US
Hung Kwong - Aliso Viejo CA, US

International Classification:

C07F 9/02
A61K 31/685
C12P 13/00

US Classification:

435128, 514 78, 554 78

Abstract:

A method for the preparation of highly polyunsaturated fatty acid-containing phosphatidylserine and phosphatidic acid by phospholipase D-catalyzed transphosphatidylation of fish liver phosphatidylcholine and L-serine is disclosed.