Su Lan Chen from Honolulu, HI, age 76

Us Patents

Method For Preparation Of Polyunsaturated Fatty Acid-Containing Phosphatidylserine
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US Patent:

8431369, Apr 30, 2013
Filed:

Jan 27, 2011
Appl. No.:

13/015276
Inventors:

Su Chen - San Antonio TX, US
Hung Kwong - San Antonio TX, US
International Classification:

C12P 7/64
US Classification:

435134, 4352535, 435198
Abstract:

A method for the preparation of the polyunsaturated fatty acids-containing phosphatidylserine, the method comprising: combining L-serine with a fish liver phosphatidylcholine having a polyunsaturated fatty acid to form a mixture; reacting the mixture with phospholipase D to effect transphosphatidylation of L-serine and the phosphatidylcholine having polyunsaturated fatty acids to produce the polyunsaturated fatty acids-containing phosphatidylserine.

Composition And Method For Promoting Survival Of Aged Basal Forebrain Cholinergic Neuron Leading To Provention And Treatment Of Age-Related Neurodegenerative Disorder
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US Patent:

20110003775, Jan 6, 2011
Filed:

Jul 3, 2009
Appl. No.:

12/497583
Inventors:

Su Chen - San Antonio TX, US
Rainbow Chen - San Antonio TX, US
International Classification:

A61K 31/661
A61P 25/28
US Classification:

514148
Abstract:

A method of treating a subject and preventing in a subject age-dependent basal forebrain cholinergic dysfunction related neurodegenerative disorders, comprising: administering a lipid composition comprising a therapeutically effective amount of highly enriched 1-acyl chains/2-docosahexaenoic acid containing molecular species of highly pure phospholipids to promote survival of aged basal forebrain cholinergic neurons, the phospholipids selected from the group consisting of phosphatidylserine, phosphatidylethanolamine, and phosphatidyl-monomethylethanolamine. A composition for treating a subject and preventing in a subject age-dependent basal forebrain cholinergic dysfunction related neurodegenerative disorders, the composition comprising: a lipid composition comprising: a therapeutically effective amount of highly enriched 1-acyl chains/2-docosahexaenoic acid containing molecular species of highly pure phospholipids to promote survival of aged basal forebrain cholinergic neurons, the phospholipids selected from the group consisting of phosphatidylserine, phosphatidylethanolamine, and phosphatidyl-monomethylethanolamine. A process for preparing a lipid composition comprising a therapeutically amount of natural source-based highly enriched 1-acyl chains/2-docosahexaenoic acid containing molecular species of highly pure phosphatidylserine to promote survival of aged basal forebrain cholinergic neurons; the process comprising: purifying a natural source-based phosphatidylcholine by silica chromatography; obtaining a related lysophosphatidylserine species by phospholipase A2 catalysis of transphosphatidylated natural source-based phosphatidylserine species; acylating the lysophosphatidylserine species with natural docosahexaenoic acid to form 1-acyl chains/2-docosahexaenoic acid containing phosphatidylserine species; and purifying the 1-acyl cgains/2-docosahexaenoic acid containing phosphatidylserine species by silica chromatography.