Irina C. Jacobson - Sammamish WA, US Ruth R. Wexler - Chadds Ford PA, US Suanne Nakajima - Cambridge MA, US Mimi L. Quan - Yardley PA, US Shuaige Wang - West Chester PA, US Joanne M. Smallheer - Yardley PA, US Jennifer Qiao - Princeton NJ, US
Assignee:
Bristol-Myers Squibb Pharma Company - Princeton NJ
International Classification:
C07D211/06 A61K031/445 A61P007/02
US Classification:
514319, 546205
Abstract:
The present application describes monocyclic or bicyclic carbocycles and heterocycles and derivatives thereof of Formula I: or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.
Aza-Peptide Macrocyclic Hepatitis C Serine Protease Inhibitors
Frank X. H. Wu - Shrewsbury MA, US Suanne Nakajima - Cambridge MA, US Zhi-Hui Lu - Shrewsbury MA, US Ying Sun - Waltham MA, US Zhenwei Miao - Medway MA, US Yat Sun Or - Watertown MA, US Zhe Wang - Hockessin DE, US
Assignee:
Enanta Pharmaceuticals, Inc. - Watertown MA
International Classification:
A61K 38/00
US Classification:
514 10
Abstract:
The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof:.
Quinoxalinyl Macrocyclic Hepatitis C Serine Protease Inhibitors
Suanne Nakajima - Cambridge MA, US Zhenwei Miao - Medway MA, US Ying Sun - Waltham MA, US Datong Tang - Malden MA, US Guoyou Xu - Auburndale MA, US Brian Porter - Cambridge MA, US Yat Sun Or - Watertown MA, US Zhe Wang - Hockessin DE, US
Zhenwei Miao - San Diego CA, US Ying Sun - Waltham MA, US Suanne Nakajima - Cambridge MA, US Datong Tang - Malden MA, US Zhe Wang - Hockessin DE, US Yat S. Or - Watertown MA, US
Assignee:
Enanta Pharmaceuticals, Inc. - Watertown MA
International Classification:
A61K 38/00
US Classification:
514 18
Abstract:
The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof:.
Quinoxalinyl Macrocyclic Hepatitis C Serine Protease Inhibitors
Suanne Nakajima - Cambridge MA, US Zhenwei Miao - Medway MA, US Ying Sun - Waltham MA, US Datong Tang - Malden MA, US Gouyou Xu - Auburndale MA, US Brian Porter - Cambridge MA, US Yat Sun Or - Watertown MA, US Zhe Wang - Hockessin DE, US
Assignee:
Enanta Pharmaceuticals, Inc. - Watertown MA
International Classification:
A61P 31/12
US Classification:
51425505
Abstract:
The present invention relates to compounds of Formula I or II, or a pharmaceutically acceptable salt, ester, or prodrug, thereof:.
Quinoxalinyl Macrocyclic Hepatitis C Serine Protease Inhibitors
Suanne Nakajima - Winchester MA, US Zhenwei Miao - San Diego CA, US Ying Sun - Waltham MA, US Datong Tang - Newton MA, US Guoyou Xu - Framingham MA, US Brian Porter - Lebanon NH, US Yat Sun Or - Watertown MA, US Zhe Wang - Hockessin DE, US
Zhenwei Miao - San Diego CA, US Ying Sun - Waltham MA, US Suanne Nakajima - Cambridge MA, US Datong Tang - Malden MA, US Frank Wu - Shrewsbury MA, US Guoyou Xu - Auburndale MA, US Yat S. Or - Watertown MA, US Zhe Wang - Hockessin DE, US
Assignee:
Enanta Pharmaceuticals, Inc. - Watertown MA
International Classification:
C07D 245/00 C07D 487/00 A61K 31/33 A01N 43/00
US Classification:
514183, 540471
Abstract:
The present invention relates to compounds of Formula I, II or Ill, or a pharmaceutically acceptable salt, ester, or prodrug, thereof:wherein W is a substituted or unsubstituted heterocyclic ring system. The compounds inhibit serine protease activity, particularly the activity of hepatitis c virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis c virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
Tri-Peptide Hepatitis C Serine Protease Inhibitors
Zhenwei Miao - Medway MA, US Ying Sun - Waltham MA, US Suanne Nakajima - Cambridge MA, US Datong Tang - Malden MA, US Zhe Wang - Hockessin DE, US Yat Sun Or - Watertown MA, US
Assignee:
Enanta Pharmaceuticals, Inc. - Watertown MA
International Classification:
A61K 38/00
US Classification:
530333
Abstract:
The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof:.
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