Subhash Kanubhai Patel

Address:

3340 W North Shr Ave, Lincolnwood, IL 60712

VIN:

1N4AL21E07N443611

Make:

NISSAN

Model:

ALTIMA

Year:

2007

US Patent:

6417366, Jul 9, 2002

Filed:

Mar 3, 2000

Appl. No.:

09/518392

Inventors:

Michael S. Allen - Trevor WI
Ramiya H. Premchandran - Gurnee IL
Stephen Condon - Kenosha WI
John A. DeMattei - Gurnee IL
Steven A. King - Gurnee IL
Lawrence Kolaczkowski - Gurnee IL
Sukumar Manna - Libertyville IL
Paul J. Nichols - Wildwood IL
Hemant H. Patel - Bodakdev, IN
Subhash R. Patel - Chicago IL
Daniel J. Plata - Wadsworth IL
Eric J. Stoner - Kenosha WI
Steven J. Wittenberger - Mundelein IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07D21516

US Classification:

546153, 546167, 546180

Abstract:

The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or a substrate that can be reduced to obtain the same.

US Patent:

6579986, Jun 17, 2003

Filed:

Apr 29, 2002

Appl. No.:

10/134777

Inventors:

Michael S. Allen - Trevor WI
Ramiya H. Premchandran - Gurnee IL
Stephen Condon - Kenosha WI
John A. DeMattei - Gurnee IL
Steven A. King - Gurnee IL
Lawrence Kolaczkowski - Gurnee IL
Sukumar Manna - Libertyville IL
Paul J. Nichols - Wildwood IL
Hemant H. Patel - Bodakdev, IN
Subhash R. Patel - Chicago IL
Daniel J. Plata - Wadsworth IL
Eric J. Stoner - Kenosha WI
Steven J. Wittenberger - Mundelein IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07D21536

US Classification:

546155, 514311, 514312, 514313, 514314, 546159, 546176, 546180

Abstract:

The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or a substrate that can be reduced to obtain the same.

US Patent:

7074932, Jul 11, 2006

Filed:

May 7, 2003

Appl. No.:

10/431018

Inventors:

Michael S. Allen - Trevor WI, US
Ramiya H. Premchandran - Gurnee IL, US
Stephen Condon - Kenosha WI, US
John A. DeMattei - Gurnee IL, US
Steven A. King - Gurnee IL, US
Lawrence Kolaczkowski - Gurnee IL, US
Sukumar Manna - Libertyville IL, US
Paul J. Nichols - Wildwood IL, US
Hemant H. Patel - Bodakdev, Ahmedabad 380015, IN
Subhash R. Patel - Chicago IL, US
Daniel J. Plata - Wadsworth IL, US
Eric J. Stoner - Kenosha WI, US
Steven J. Wittenberger - Mundelein IL, US

International Classification:

C07D 215/16
C07D 215/18

US Classification:

546153, 546167, 546180

Abstract:

The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or a substrate that can be reduced to obtain the same.

US Patent:

7700614, Apr 20, 2010

Filed:

Dec 14, 2005

Appl. No.:

11/300671

Inventors:

Madhup K. Dhaon - Mundelein IL, US
Chi-nung Hsiao - Taipei County, TW
Subhash R. Patel - Chicago IL, US
Peter J. Bonk - Westerly RI, US
Sanjay R. Chemburkar - Gurnee IL, US
Yong Chen - Lake Villa IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07D 498/18

US Classification:

514291, 540456

Abstract:

A single-step, one-pot process to obtain zotarolimus and other rapamycin derivatives on large scale is presented, which improves currently available synthesis schemes. In one embodiment, dried rapamycin is dissolved in isopropylacetate (IPAc). The solution is cooled, and 2,6-Lutidine is added, followed slowly adding triflic anhydride at −30 C. Salts are then removed by filtration. Tetrazole, followed by a tert-base diisopropylethylamine (DIEA) is added to the triflate solution. After incubation at room temperature, the product is concentrated and purified by a silica gel column using THF/heptane as eluant. The fractions containing the product are collected, concentrated, and purified again using an acetone/heptane column. The product containing fractions are concentrated. The product is dissolved in t-BME and precipitated with heptane.

US Patent:

8129521, Mar 6, 2012

Filed:

Feb 23, 2010

Appl. No.:

12/711072

Inventors:

Madhup K. Dhaon - Mundelein IL, US
Chi-nung Hsiao - Taipei County, TW
Subhash R. Patel - Chicago IL, US
Peter J. Bonk - Westerly RI, US
Sanjay R. Chemburkar - Gurnee IL, US
Yong Y. Chen - Lake Villa IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07D 498/18

US Classification:

540456

Abstract:

A single-step, one-pot process to obtain zotarolimus and other rapamycin derivatives on large scale is presented, which improves currently available synthesis schemes. In one embodiment, dried rapamycin is dissolved in isopropylacetate (IPAc). The solution is cooled, and 2,6-Lutidine is added, followed slowly adding triflic anhydride at −30 C. Salts are then removed by filtration. Tetrazole, followed by a tert-base diisopropylethylamine (DIEA) is added to the triflate solution. After incubation at room temperature, the product is concentrated and purified by a silica gel column using THF/heptane as eluant. The fractions containing the product are collected, concentrated, and purified again using an acetone/heptane column. The product containing fractions are concentrated. The product is dissolved in t-BME and precipitated with heptane.

US Patent:

20060128962, Jun 15, 2006

Filed:

Feb 6, 2006

Appl. No.:

11/348155

Inventors:

Michael Allen - Trevor WI, US
Ramiya Premchandran - Gurnee IL, US
Stephen Condon - Kenosha WI, US
John DeMattei - Gurnee IL, US
Steven King - Gurnee IL, US
Lawrence Kolaczkowski - Gurnee IL, US
Sukumar Manna - Libertyville IL, US
Paul Nichols - Wildwood IL, US
Hemant Patel - , US
Subhash Patel - Chicago IL, US
Daniel Plata - Wadsworth IL, US
Eric Stoner - Kenosha WI, US
Steven Wittenberger - Mundelein IL, US

International Classification:

C07D 215/12
C07C 69/52
C07D 215/14

US Classification:

546168000, 560222000

Abstract:

The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or a substrate that can be reduced to obtain the same.

US Patent:

53547608, Oct 11, 1994

Filed:

Mar 24, 1992

Appl. No.:

7/857038

Inventors:

Henning Petersen - Lyngby, DK
Peter Nielsen - Herlev, DK
Michael Cain - Grayslake IL
Subhash Patel - Chicago IL

Assignee:

Novo Nordisk A/S - Bagsvaerd

International Classification:

C07D40914
A61K 31445

US Classification:

514326

Abstract:

The invention provides crystalline Tiagabine hydrochloride monohydrate, process for its preparation, compositions containing the same and its therapeutic use as anti-epileptic agent.