Tomoko Sunami - Naka-Gun, JP Mari Machida - Moriya-Shi, JP Sanjeev K. Munshi - Ambler PA, US Sujata Sharma - Eagleville PA, US
International Classification:
C12Q 1/48 C12N 9/12
US Classification:
435 15, 435194
Abstract:
Crystallization of the 70 kDa ribosomal protein S6 kinase polypeptide 1 (p70S6K1) kinase domain for X-ray crystallography analysis to generate the three-dimensional structure of the p70S6K1 kinase domain is described. Further described is the use of the three 5 dimensional structure of p70S6K1 kinase domain for identifying and designing ligands or low molecular weight molecules that specifically bind to and modulate (inhibit) the kinase activity of p70S6K1. These ligands or molecules can be used for the treatment of metabolic disorders such as diabetes and for the treatment of various cancers.
Peter Peizhi Luo - Lansdale PA, US Pingyu Zhong - Blue Bell PA, US Mark Hsieh - Jenkintown PA, US Yan Li - San Jose CA, US Xinwei Wang - Germantown MD, US Feng Dong - Lansdale PA, US Andrei Golosov - Cambridge MA, US Yan Ni - Westfield NJ, US Weirong Wang - Harleysville PA, US Laurence B. Peterson - Westfield NJ, US Rose Cubbon - Fanwood NJ, US Sujata Sharma - Eagleville PA, US Jon Condra - Doylestown PA, US Jun Lu - Lansdale PA, US Gopalakrishnan Parthasarathy - Hillsborough NJ, US Stephen Soisson - Hillsborough NJ, US Noel Byrne - Doylestown PA, US
Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
Dr. Sharma graduated from the Gov't Med Coll, Baba Farid Univ Hlth Sci, Patiala, Punjab, India in 2005. She works in Houston, TX and specializes in Family Medicine.
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Sujata Sharma
Work:
Placed at Dr. Reddy's Laboratories
Education:
K.V.S., Kurukshetra University - Engg.
Tagline:
Firm believer of the Almighty...focussed and ardent!!
"Healthy foods and nutritionally balanced diet can help in improving blood sugar levels and also keeping them in the desired target range. Parm You need to look for options which are healthy and low in carbs," says Sujata Sharma, nutritionist and diabetes care coach, BeatO.