Amazon Web Services
Genomics and Healthcare Solutions Architect, Academic Medical Centers
Bristol-Myers Squibb
Senior Research Scientist
Strand Life Sciences Jun 1, 2013 - Apr 2016
Senior Applications Scientist
Medeolinx Sep 2012 - Apr 2013
Bioinformatics Scientist
Indian Institute of Science Jun 1, 2010 - Sep 1, 2012
Senior Research Fellow
Education:
The Johns Hopkins University
Master of Science, Masters, Bioinformatics
University of Maryland
Master of Science, Masters, Computer Engineering
Pg Center, Kolar
Bachelor of Engineering, Bachelors, Communication, Electronics
Skills:
Bioinformatics Genomics Molecular Biology Genetics Life Sciences Cancer Data Analysis Cell Computational Biology Dna Sequencing Microarray Analysis Sequence Analysis Nextgen Personalized Medicine Cancer Genomics Ngs Molecular Oncology Amazon Web Services R Python Perl Biostatistics
Interests:
Science and Technology Environment Education Children
- Princeton NJ, US Nathan O. SIEMERS - Pacific Grove CA, US Dimple PANDYA - Princeton NJ, US Han CHANG - West Windsor NJ, US Teresa K. SANCHEZ - Princeton NJ, US Christopher T. HARBISON - Hamilton NJ, US Peter M. SZABO - Pennington NJ, US Zachary S. BOYD - Skillman NJ, US Xiaozhong QIAN - Pennington NJ, US Samy Abdel SACI - Lawrenceville NJ, US Tina C. YOUNG - Lawrence Township NJ, US Sujaya SRINIVASAN - Princeton Junction NJ, US Megan M. WIND-ROTOLO - Newtown PA, US Jasmine RIZZO - Edison NJ, US Donald G. JACKSON - Hopkinton MA, US Alice M. WALSH - Glenside PA, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07K 16/28 A61P 35/00
Abstract:
The disclosure provides a method for treating a subject afflicted with a tumor comprising administering to the subject a therapeutically effective amount of an anti-PD-1 antibody or antigen-binding portion thereof or an anti-PD-L1 antibody or anti-gen-binding portion thereof, wherein the subject is identified as having a high inflammatory gene signature score and a tumor that has a high tumor mutation burden (TMB) status. In some embodiments, the high inflammatory gene signature score is determined by measuring the expression of a panel of inflammatory genes in a tumor sample obtained from the subject, wherein the inflammatory gene panel comprises CD274 (PD-L1), CD8A, LAG3, and STAT1.
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