Susan D Henke

US Patent:

7004976, Feb 28, 2006

Filed:

Nov 5, 2003

Appl. No.:

10/702407

Inventors:

Richard L. Ornberg - Wildwood MO, US
Kishore Udipi - San Rosa CA, US
Denis Forster - Ladue MO, US
Dennis P. Riley - Chesterfield MO, US
Kenneth B. Thurmond - Plano TX, US
Susan Henke - Webster Groves MO, US
Kerry Brethaur - Belleville IL, US
Saikat Joardar - Ballwin MO, US

Assignee:

Pharmacia Corporation - St. Louis MO

International Classification:

A61F 2/02
A61K 31/715
C08G 37/08

US Classification:

623 2358, 514 54, 536 20

Abstract:

This invention provides modified biopolymers comprising biopolymers attached to at least one non-proteinaceous catalyst capable of dismutating superoxide in the biological system or precursor ligand thereof. The invention further provides pharmaceutical compositions comprising the modified biopolymer and therapeutic methods comprising administering the modified biopolymer to a subject in need thereof.

US Patent:

7407645, Aug 5, 2008

Filed:

Dec 16, 2003

Appl. No.:

10/737486

Inventors:

William L. Neumann - Ballwin MO, US
Dennis P. Riley - Chesterfield MO, US
Randy H. Weiss - St. Louis MO, US
Susan L. Henke - Webster Groves MO, US
Patrick J Lennon - Webster Groves MO, US
Karl W. Aston - Pacific MO, US

Assignee:

Metaphore Pharmaceuticals, Inc. - St., Louis MO

International Classification:

A61K 51/00
A61M 36/14

US Classification:

424 173, 424 111, 424 165, 424 149, 424 169, 540450

Abstract:

The present invention is directed to bioconjugates of complexes represented by the formula:.

US Patent:

7445641, Nov 4, 2008

Filed:

May 26, 2000

Appl. No.:

09/580007

Inventors:

Richard Ornberg - Chesterfield MO, US
Kishore Udipi - Chesterfield MO, US
Denis Forster - St. Louis MO, US
Dennis Riley - Chesterfield MO, US
Bruce Thurmond - Ballwin MO, US
Susan Henke - Webster Groves MO, US
Kerry Brethauer - Belleville IL, US

Assignee:

Pharmacia Corporation - St. Louis MO

International Classification:

A61F 2/28
A61K 38/16
C08B 37/08
C07K 14/728

US Classification:

623 2357, 623 2358, 514 54, 514 55, 530400, 536 53

Abstract:

The present invention relates to biomaterials modified with non-proteinaceous catalysts for the dismutation of superoxide, and processes for making such materials. This modification may be by covalent conjugation, copolymerization, or admixture of the non-proteinaceous catalysts with the biomaterial. The resulting modified biomaterials exhibit a marked decrease in inflammatory response and subsequent degradation when placed in contact with vertebrate biological systems.

US Patent:

20040057904, Mar 25, 2004

Filed:

Apr 1, 2003

Appl. No.:

10/405044

Inventors:

William Neumann - Ballwin MO, US
Dennis Riley - Ballwin MO, US
Randy Weiss - St. Louis MO, US
Susan Henke - Webster Groves MO, US
Patrick Lennon - Clayton MO, US
Karl Aston - Pacific MO, US

Assignee:

MetaPhore Pharmaceuticals, Inc.

International Classification:

A61K049/00

US Classification:

424/009363

Abstract:

The present invention is directed to bioconjugates of complexes represented by the formula: wherein R, R′, R, R′, R, R′, R, R′, R, R′, R, R′, R, R′, R, R′, R, R′, R, R′, M, X, Y, Z and n are defined herein for use as contrast agents in diagnostic imaging.

US Patent:

20040110722, Jun 10, 2004

Filed:

Nov 5, 2003

Appl. No.:

10/702764

Inventors:

Richard Ornberg - Wildwood MO, US
Kishore Udipi - San Rosa CA, US
Denis Forster - Ladue MO, US
Dennis Riley - Chesterfield MO, US
Kenneth Thurmond - Plano TX, US
Susan Henke - Webster Groves MO, US
Kerry Brethauer - Belleville IL, US
Saikat Joardar - Rockville MD, US

International Classification:

A61F002/02
A61K031/728
C08B037/00

US Classification:

514/054000, 623/902000, 536/053000

Abstract:

The present invention relates to hyaluronic acid polymers modified with non-proteinaceous catalysts for the dismutation of superoxide, and processes for making such materials. The invention further provides pharmaceutical compositions comprising the modified biopolymer and therapeutic methods comprising administering the modified biopolymer to a subject in need thereof.

US Patent:

20060089710, Apr 27, 2006

Filed:

Sep 15, 2005

Appl. No.:

11/227318

Inventors:

Richard Ornberg - Wildwood MO, US
Kishore Udipi - San Rosa CA, US
Denis Forster - Ladue MO, US
Dennis Riley - Chesterfield MO, US
Kenneth Thurmond - Plano TX, US
Susan Henke - Webster Groves MO, US
Kerry Brethauer - Belleville IL, US
Saikat Joardar - Ballwin MO, US

International Classification:

A61F 2/06
C08B 37/00

US Classification:

623001510, 536053000, 530400000

Abstract:

This invention provides modified biopolymers comprising biopolymers attached to at least one non-proteinaceous catalyst capable of dismutating superoxide in the biological system or precursor ligand thereof. The invention further provides pharmaceutical compositions comprising the modified biopolymer and therapeutic methods comprising administering the modified biopolymer to a subject in need thereof.

US Patent:

20090098047, Apr 16, 2009

Filed:

Aug 4, 2008

Appl. No.:

12/185433

Inventors:

William L. Neumann - Ballwin MO, US
Dennis P. Riley - Ballwin MO, US
Randy H. Weiss - St. Louis MO, US
Susan L. Henke - Webster Groves MO, US
Patrick J. Lennon - Clayton MO, US
Karl W. Aston - Pacific MO, US

Assignee:

Inotek Pharmaceuticals - Wellington
Kereos, Inc. - St. Louis MO

International Classification:

A61K 51/08
A61K 49/10
A61K 49/14
A61K 49/04
C07D 225/02
C07K 7/64
A61K 51/06
A61K 49/22
A61K 51/04

US Classification:

424 169, 424 9363, 424 934, 424 942, 424 95, 424 165, 424 173, 540465, 530317

Abstract:

The present invention is directed to bioconjugates of complexes represented by the formula:wherein R, R′, R, R′, R, R′, R, R′, R, R′, R, R′, R, R′, R, R′, R, R′, R, R′, M, X, Y, Z and n are defined herein for use as contrast agents in diagnostic imaging.

US Patent:

59764988, Nov 2, 1999

Filed:

Aug 16, 1996

Appl. No.:

8/698612

Inventors:

William L. Neumann - Ballwin MO
Dennis P. Riley - Ballwin MO
Randy H. Weiss - St. Louis MO
Susan L. Henke - Webster Groves MO
Patrick J. Lennon - Clayton MO
Karl W. Aston - Pacific MO

International Classification:

A61K 4900
G01N 3100

US Classification:

424 91

Abstract:

The present invention is directed to complexes represented by the formula: ##STR1## wherein R, R', R. sub. 1, R'. sub. 1, R. sub. 2, R'. sub. 2, R. sub. 3, R'. sub. 3, R. sub. 4, R'. sub. 4, R. sub. 5, R'. sub. 5, R. sub. 6, R'. sub. 6, R. sub. 7, R'. sub. 7, R. sub. 8, R'. sub. 8, R. sub. 9, R'. sub. 9, M, X, Y, Z and n are defined herein for use as contrast agents in diagnostic imaging.