Susan Emma Kelly

US Patent:

6576235, Jun 10, 2003

Filed:

Aug 6, 1999

Appl. No.:

09/370084

Inventors:

L. David Williams - Fremont CA
Michael S. Hershfield - Durham NC
Susan J. Kelly - Chapel Hill NC
Mark G. P. Saifer - San Carlos CA
Merry R. Sherman - San Carlos CA

Assignee:

Mountain View Pharmaceuticals, Inc. - Menlo Park CA
Duke University - Durham NC

International Classification:

A61K 3844

US Classification:

424 944, 435189, 435191, 4352523, 4353201, 536 232, 530350

Abstract:

A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme.

US Patent:

7723089, May 25, 2010

Filed:

Apr 19, 2001

Appl. No.:

09/839946

Inventors:

L. David Williams - Fremont CA, US
Michael S. Hershfield - Durham NC, US
Susan J. Kelly - Chapel Hill NC, US
Mark G. P. Saifer - San Carlos CA, US
Merry R. Sherman - San Carlos CA, US

Assignee:

Mountain View Pharmaceuticals, Inc. - Menlo Park CA
Duke University - Durham NC

International Classification:

C12N 9/04
C12N 9/06

US Classification:

435190, 435191, 435440, 536 232

Abstract:

A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme.

US Patent:

7927589, Apr 19, 2011

Filed:

Aug 3, 2007

Appl. No.:

11/833590

Inventors:

L. David Williams - Fremont CA, US
Michael S. Hershfield - Durham NC, US
Susan J. Kelly - Chapel Hill NC, US
Mark G. P. Saifer - San Carlos CA, US
Merry R. Sherman - San Carlos CA, US

Assignee:

Mountain View Pharmaceuticals, Inc. - Menlo Park CA

International Classification:

A61K 38/44
C12N 9/02
C12N 9/06

US Classification:

424 944, 424 943, 435181, 435188, 435189, 435191

Abstract:

A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme.

US Patent:

7927852, Apr 19, 2011

Filed:

Aug 3, 2007

Appl. No.:

11/882750

Inventors:

Merry R. Sherman - San Carlos CA, US
Mark G. P. Saifer - San Carlos CA, US
L. David Williams - Fremont CA, US
Michael S. Hershfield - Durham NC, US
Susan J. Kelly - Chapel Hill NC, US

Assignee:

Mountain View Pharmaceuticals, Inc. - Menlo Park CA

International Classification:

C12N 9/04
C12N 15/00
A61K 38/44
C07K 1/00

US Classification:

435190, 435191, 435440, 424 944, 530350

Abstract:

A naturally occurring or recombinant protein, especially a mutein of porcine urate oxidase (uricase), that is essentially free of large aggregates can be rendered substantially non-immunogenic by conjugation with a sufficiently small number of strands of polymer such that the bioactivity of the protein is essentially retained in the conjugate. Such conjugates are unusually well suited for treatment of chronic conditions because they are less likely to induce the formation of antibodies and/or accelerated clearance than are similar conjugates prepared from protein preparations containing traces of large aggregates.

US Patent:

8067553, Nov 29, 2011

Filed:

Apr 28, 2010

Appl. No.:

12/769570

Inventors:

L. David Williams - Fremont CA, US
Michael S. Hershfield - Durham NC, US
Susan J. Kelly - Chapel Hill NC, US
Mark G. P. Saifer - San Carlos CA, US
Merry R. Sherman - San Carlos CA, US

Assignee:

Mountain View Pharmaceuticals, Inc. - Menlo Park CA
Duke University - Durham NC

International Classification:

A23J 1/00

US Classification:

530412, 435189, 435190, 435191

Abstract:

A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme.

US Patent:

8618267, Dec 31, 2013

Filed:

Apr 8, 2011

Appl. No.:

13/083152

Inventors:

L. David Williams - Fremont CA, US
Michael S. Hershfield - Durham NC, US
Susan J. Kelly - Chapel Hill NC, US
Mark G. P. Saifer - San Carlos CA, US
Merry R. Sherman - San Carlos CA, US

Assignee:

Mountain View Pharmaceuticals, Inc. - Menlo Park CA
Duke University - Durham NC

International Classification:

A61K 38/44
C12N 9/02

US Classification:

530412, 435189, 435190, 435191

Abstract:

A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme.

US Patent:

20100323423, Dec 23, 2010

Filed:

Apr 28, 2010

Appl. No.:

12/769572

Inventors:

L. David WILLIAMS - Fremont CA, US
Michael S. Herschfield - Durham NC, US
Susan J. Kelly - Chapel Hill NC, US
Mark G.P. Saifer - San Carlos CA, US
Merry R. Sherman - San Carlos CA, US

International Classification:

C12N 9/06

US Classification:

435191

Abstract:

A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme.

US Patent:

20110287466, Nov 24, 2011

Filed:

Apr 13, 2011

Appl. No.:

13/085793

Inventors:

Merry R. Sherman - San Carlos CA, US
Mark G.P. Saifer - San Carlos CA, US
L. David Williams - Fremont CA, US
Michael S. Hershfield - Durham NC, US
Susan J. Kelly - Chapel Hill NC, US

International Classification:

C12Q 1/26

US Classification:

435 25

Abstract:

A naturally occurring or recombinant protein, especially a mutein of porcine urate oxidase (uricase), that is essentially free of large aggregates can be rendered substantially non-immunogenic by conjugation with a sufficiently small number of strands of polymer such that the bioactivity of the protein is essentially retained in the conjugate. Such conjugates are unusually well suited for treatment of chronic conditions because they are less likely to induce the formation of antibodies and/or accelerated clearance than are similar conjugates prepared from protein preparations containing traces of large aggregates.