Susan T Laing

US Patent:

20080305156, Dec 11, 2008

Filed:

Mar 7, 2008

Appl. No.:

12/044189

Inventors:

Susan T. Laing - Houston TX, US
Shaoling Huang - Houston TX, US
David D. McPherson - Houston TX, US
Christy K. Holland - Cincinnati OH, US
Melvin E. Klegerman - Houston TX, US

International Classification:

A61K 9/127
A61P 7/02

US Classification:

424450

Abstract:

We disclose a composition comprising an echogenic liposome (ELIP) having an exterior surface, an interior surface, and at least one bilayer comprising at least one lipid selected from the group consisting of saturated phospholipids, unsaturated phospholipids, mixed phospholipids, and cholesterol, and a thrombolytic compound trapped by the ELIP. We also disclose a method of treating a medical condition in a patient characterized by a thrombus in the patient's vasculature, comprising administering to the patient the composition in an amount effective to reduce the size of the thrombus.

US Patent:

20190365649, Dec 5, 2019

Filed:

May 31, 2019

Appl. No.:

16/428681

Inventors:

- Austin TX, US
Shao-Ling Huang - Sugarland TX, US
Melvin Klegerman - Houston TX, US
Susan T. Laing - Houston TX, US
Patrick Kee - Houston TX, US
Tao Peng - Houston TX, US
Hyunggun Kim - Hwasung, KR
Melanie Moody - Sugar Land TX, US

Assignee:

BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM - Austin TX

International Classification:

A61K 9/127
A61K 31/506
A61K 47/54
A61K 47/06

Abstract:

Disclosed are compositions comprising a first liposome, comprising at least one lipid selected from the group consisting of saturated phospholipids, unsaturated phospholipids, mixed phospholipids, and cholesterol, and at least one vasodilator; and a second liposome, comprising at least one lipid selected from the group consisting of saturated phospholipids, unsaturated phospholipids, mixed phospholipids, and cholesterol, at least one thiazolidinedione, and at least one compound having an affinity for at least one component of an atheroma. Also disclosed are methods for forming the compositions and methods of using the compositions to ameliorate atheroma.

US Patent:

20180042841, Feb 15, 2018

Filed:

Oct 10, 2017

Appl. No.:

15/729631

Inventors:

Susan T. Laing - Houston TX, US
Shaoling Huang - Houston TX, US
David D. McPherson - Houston TX, US
Christy K. Holland - Cincinnati OH, US
Melvin E. Klegerman - Houston TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX
Univeristy of Cincinnati - Cincinatti OH

International Classification:

A61K 9/00
A61K 9/127
A61K 49/22

Abstract:

We disclose a composition comprising an echogenic liposome (ELIP) having an exterior surface, an interior surface, and at least one bilayer comprising at least one lipid selected from the group consisting of saturated phospholipids, unsaturated phospholipids, mixed phospholipids, and cholesterol, and a thrombolytic compound trapped by the ELIP. We also disclose a method of treating a medical condition in a patient characterized by a thrombus in the patient's vasculature, comprising administering to the patient the composition in an amount effective to reduce the size of the thrombus.