Susan Y Lin

US Patent:

20200276299, Sep 3, 2020

Filed:

Sep 7, 2018

Appl. No.:

16/645456

Inventors:

- Seattle WA, US
Susan S. LIN - Seattle WA, US

International Classification:

A61K 39/21
A61K 47/24
A61K 39/04
A61K 39/015

Abstract:

Provided herein are liposomal formulations containing saponin and optionally, a lipopolysaccharide. Also provided IC herein are pharmaceutical compositions and vaccine compositions comprising the liposomal formulations and an antigen. The pharmaceutical compositions and vaccine compositions are capable of eliciting or enhancing of an immune response, for example, for vaccine or therapeutic uses. Compositions and methods related to making the liposomal formulations and using the liposomal formulations for eliciting or enhancing an immune response are also provided.

US Patent:

20200230056, Jul 23, 2020

Filed:

Jun 15, 2018

Appl. No.:

16/622908

Inventors:

- Seattle WA, US
Amit Praful KHANDHAR - Seattle WA, US
Neal VAN HOEVEN - Seattle WA, US
Jesse H. ERASMUS - Seattle WA, US
Susan S. LIN - Seattle WA, US

International Classification:

A61K 9/127
A61K 9/107
A61K 47/10
A61K 47/26
A61K 39/39
A61K 31/713

Abstract:

Provided herein are nanostructured lipid carrier compositions, and methods of making and using thereof. The compositions comprise a nanostructured lipid carrier (NLC), where the NLC comprises an oil core comprising a mixture of a liquid phase lipid and a solid phase lipid, a cationic lipid, a sorbitan ester, and a hydrophilic surfactant, and optionally a bioactive agent. The bioactive agent can be associated with the NLC. The compositions are capable of delivery of a biomolecule to a cell for the generation of an immune response, for example, for vaccine, therapeutic, or diagnostic uses. Compositions and methods related to making the compositions and using the compositions for stimulating an immune response are also provided.