Susan M Love

US Patent:

6391026, May 21, 2002

Filed:

Sep 16, 1999

Appl. No.:

09/397753

Inventors:

David Hung - Belmont CA
Chris Ken - San Mateo CA
Julian Nikolchev - Portola Valley CA
Susan Love - Pacific Palisades CA
Shawn OLeary - San Jose CA

Assignee:

Pro Duct Health, Inc. - Menlo Park CA

International Classification:

A61B 1818

US Classification:

606 41, 606 2, 606 13, 606 14, 606 20, 606 27, 606 32

Abstract:

Methods, systems, and kits for treating breast tissue rely on transferring energy to or from cells lining an individual breast duct. Energy can be introduced into the breast duct, e. g. , by filling the duct with an electrically conductive medium and applying radiofrequency energy to the medium. Other energy forms could also be used, such as light, ultrasound, radiation, microwave energy, heat, cold, direct current, and the like. By treating individual breast ducts, cancerous and pre-cancerous conditions originating in the duct can be effectively treated.

US Patent:

6455027, Sep 24, 2002

Filed:

Sep 15, 1998

Appl. No.:

09/153564

Inventors:

Sanford H. Barsky - Los Angeles CA
Susan M. Love - Pacific Palisades CA
Mary L. Alpaugh - Los Angeles CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61B 500

US Classification:

424 98, 424 96, 424 91, 435 71, 435 723, 436543, 604 28, 604 54, 604104

Abstract:

Methods, kits, and apparatus for locating, labelling, and accessing breast ducts are described. An orifice to one or more ductal networks is marked to enhance visibility. In a first embodiment, the orifice is labelled using a specific binding substance, typically an antibody, specific for a tissue marker present on the orifice. Exemplary tissue markers include those present on the ductal epithelium, such as cytokeratins, including cytokeratin 8 and cytokeratin 18; cadhedrins, such as E cadhedrin; and epithelial membrane antigens. In a second embodiment, a dye is injected into the base of the nipple and preferentially accumulates at at least some of the orifices. Other marking techniques are also described. Marking of the ductal orifices permits reliable identification and access to each of the multiple ductal networks which may be present in an individual breast.

US Patent:

6494859, Dec 17, 2002

Filed:

Apr 28, 1999

Appl. No.:

09/301058

Inventors:

Susan M. Love - Pacific Palisades CA
David Hung - Belmont CA
Xuanmin He - Palo Alto CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61M 100

US Classification:

604 28, 604 19, 604 27, 604 48, 604 73, 604 74, 604 75, 604 76

Abstract:

Methods, kits, and apparatus for obtaining cellular, chemical, and other materials from breast ducts are described. A single milk duct is accessed and washed with a washing fluid to obtain marker materials from the lining the duct. The washing fluid is then collected, and the marker materials in the washing fluid identified and analyzed. Usually, the washing fluid is introduced using a syringe through a lumen of a dual-lumen catheter. The ductal volume is filled with the washing fluid and excess fluid flows outwardly through a second lumen of the dual-lumen catheter, from which it is collected. Methods and kits provide for collection of fluid and cells by a lavage procedure that includes applying external pressure to the breast to improve the yield of fluid and cells from the breast duct.

US Patent:

6589998, Jul 8, 2003

Filed:

Jun 9, 2000

Appl. No.:

09/590517

Inventors:

Annette Bianchi - San Mateo CA
Julian Nikolchev - Portola Valley CA
David Hung - Belmont CA
Eyal Ron - Lexington MA
Linda Gont - Cedarburg WI
Susan Love - Pacific Palisades CA
Tina Patel - San Carlos CA

Assignee:

Cytyc Health Corporation - Boxborough MA

International Classification:

A61K 4732

US Classification:

5147724, 514944, 424 7802, 424422, 424484, 424486

Abstract:

The invention is a gel composition for delivery to a breast milk duct prior to surgical excision of breast tissue including cancerous lesions. The invention also provides methods of mapping all or nearly all of a breast milk duct prior to surgical excision of breast tissue, and method of identifying part or all of a breast duct or ducts as a surgical aide to a breast surgeon. Kits to support these methods and including these compositions are also provided.

US Patent:

6629936, Oct 7, 2003

Filed:

May 10, 2001

Appl. No.:

09/852145

Inventors:

David Hung - Belmont CA
Susan Love - Pacific Palisades CA

Assignee:

Cytyc Health Corporation - Boxborough MA

International Classification:

A61B 500

US Classification:

600573, 604 74

Abstract:

Differentiating breast ducts for cancer risk status is a key element in a procedure to screen women for breast cancer. The 6 to 9 breast ducts on the human breast can be differentiated to identify those of higher risk for cancer. The higher risk ducts merit access and analysis of the ductal fluid and monitoring and/or treatment.

US Patent:

6638727, Oct 28, 2003

Filed:

May 17, 1999

Appl. No.:

09/313463

Inventors:

David T. Hung - Belmont CA
Susan Love - Pacific Palisades CA

Assignee:

Cytyc Health Corporation - Boxborough MA

International Classification:

G01N 33574

US Classification:

435 723, 4241951, 435 72, 435 71, 435 74, 436 63, 436 64, 436501, 436503

Abstract:

The invention is to methods for identifying asymptomatic patients who have a likelihood of benefiting from administration of an estrogen activity modulator for risk reduction or therapeutic treatment of breast cancer, methods for reducing risk or therapeutically treating these asymptomatic patients, and methods for monitoring the treatments.

US Patent:

6642010, Nov 4, 2003

Filed:

Feb 10, 2000

Appl. No.:

09/502404

Inventors:

Susan Love - Pacific Palisades CA
David Hung - Belmont CA
Hui Cen - Oakland CA

Assignee:

Cytyc Health Corporation - Boxborough MA

International Classification:

G01N 33574

US Classification:

435 723, 435 71, 435 721

Abstract:

The invention is to methods for screening women for breast cancer and precancer by determining a level of an estrogen-related marker. The invention further provides methods of treating such patients identified as having one or more abnormal ductal epithelial cells and an estrogen-related marker. The invention provides methods for screening patient for hormone replacement therapy (HRT), and of monitoring such patients once they begin HRT. The invention provides methods of treating peri-, menopausal or postmenopausal women for both cancer risk reduction and menopausal symptoms (or other conditions related to lowered systemic estrogen levels). The invention also provides kits for the screening, monitoring, and treating methods described.

US Patent:

6712816, Mar 30, 2004

Filed:

May 15, 2002

Appl. No.:

10/144853

Inventors:

David Hung - Belmont CA
Chris Ken - San Mateo CA
Julian Nikolchev - Portolo Valley CA
Susan Love - Pacific Palisades CA
Shawn OLeary - Mission Viejo CA

Assignee:

Cytyc Health Corporation - Boxborough MA

International Classification:

A61B 1818

US Classification:

606 41

Abstract:

Methods, systems, and kits for treating breast tissue rely on transferring energy to or from cells lining an individual breast duct. Energy can be introduced into the breast duct, e. g. , by filling the duct with an electrically conductive medium and applying radiofrequency energy to the medium. Other energy forms could also be used, such as light, ultrasound, radiation, microwave energy, heat, cold, direct current, and the like. By treating individual breast ducts, cancerous and pre-cancerous conditions originating in the duct can be effectively treated.