Susan L Raghoobar

US Patent:

54119855, May 2, 1995

Filed:

May 17, 1993

Appl. No.:

8/062881

Inventors:

Gerald F. Bills - Cranford NJ
Otto D. Hensens - Red Bank NJ
Jerrold M. Liesch - Princeton Junction NJ
Russel B. Lingham - Watchung NJ
Jon D. Polishook - Scotch Plains NJ
Michael J. Salvatore - South Plainfield NJ
Susan L. Raghoobar - Fords NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 3135

US Classification:

514460

Abstract:

Novel peptidyl derivatives of formula I are found to be potent inhibitors of interleukin-1. beta. converting enzyme (ICE). Compounds of formula I may be useful in the treatment of inflammatory or immune-based diseases of the lung and airways; central nervous system and surrounding membranes; the eyes and ears; joints, bones, and connective tissues; cardiovascular system including the pericardium; the gastrointestinal and urogenital systems; the skin and mucosal membranes. Compounds of formula I are also useful in treating the complications of infection (e. g. , gram negative shock) and tumors in which IL 1 functions as an autocrine growth factor or as a mediator of cachexia. ##STR1##.