Susan Schwendner - San Bruno CA Pieter Timmermans - Redwood City CA Jacqueline Walling - Burlingame CA
Assignee:
Tularik Inc. - So. San Francisco CA
International Classification:
A61K 3166
US Classification:
514117, 514406, 514471, 514479, 514492
Abstract:
Combination therapies are provided for the treatment of proliferative disorders which use a pentafluorobenzenesulfonamide of formula I and an antineoplastic platinum coordination complex such as cisplatin.
Combination Therapy Using Pentafluorobenzenesulfonamides And Antineoplastic Agents
Combination therapies are provided for the treatment of proliferative disorders which use a pentafluorobenzenesulfonamide of formula I and an antineoplastic agent such as gemcitabine or paclitaxel.
Combination Therapy Using Pentafluorobenzenesulfonamides And Antineoplastic Agents
Fengzhi Li - Buffalo NY, US Xiang Ling - Snyder NY, US Youcef Rustum - East Amherst NY, US Susan Schwendner - Berkeley CA, US Pieter Timmermans - Redwood City CA, US Jacqueline Walling - Burlingame CA, US
Assignee:
Amgen Inc. - Thousand Oaks CA Health Research, Inc. - Buffalo NY
Combination therapies are provided for the treatment of proliferative disorders which use a pentafluorobenzenesulfonamide of formula I and an antineoplastic agent.
Use Of Gallium To Treat Biofilm-Associated Infections
Louis Bucalo - Miami FL, US Susan Schwendner - Berkeley CA, US Uwe Wirtz - Oakland CA, US Sunil Sreedharan - South San Francisco CA, US
International Classification:
A61K 33/24
US Classification:
424617000
Abstract:
The invention provides methods, compositions, and kits for treatment or prevention of biofilm-associated infections in an individual. Methods of the invention include administration of a gallium-containing composition for treatment of an established biofilm or prevention of formation of a biofilm. Some methods include administration of a gallium-containing composition in conjunction with an antibiotic substance. Some methods include treatment or prevention of an orally-associated biofilm with a gallium-containing composition in the form of a dentrifice, mouthwash, or chewing gum composition.
Combination Therapy Using Pentafluorobenzenesulfonamides And Antineoplastic Agents
Fengzhi Li - Buffala NY, US Xiang Ling - Snyder NY, US Youcef Rustum - East Amherst NY, US Susan Schwendner - Berkeley CA, US Pieter Timmermans - Redwood City CA, US Jacqueline Walling - Carpenters, GB
Assignee:
AMGEN INC. - Thousand Oaks CA HEALTH RESEARCH, INC. - Buffalo NY
Combination therapies are provided for the treatment of proliferative disorders which use a pentafluorobenzenesulfonamide of formula I and an antineoplastic agent.
Raymond E. Counsell - Ann Arbor MI Karen L. Meyer - Norman OK Susan W. Schwendner - Ann Arbor MI Terushi Haradahira - Fukuoka, JP
Assignee:
The Board of Regents of the University of Michigan - Ann Arbor MI
International Classification:
A61K 5100 A61M 3614
US Classification:
424 177
Abstract:
Novel radioiodinated analogues of naturally-occurring phospholipid ethers are tumor-specific and have a triglycerol backbone structure which, in certain embodiments, is substituted at the 3-position with an alkyl phosphocholine and include a monoiodinated benzoyl side chain substituted at the 2-position in accordance with the general formula: ##STR1## where n=1-15 ##STR2## M=0-15; Z=. sup. 123 I,. sup. 125 I, and. sup. 131 I; Y=NH. sub. 2, NR. sub. 2, and NR. sub. 3, and R=alkyl, aralkyl.
Polyiodinated Triglyceride Analogs As Radiologic Agents
Raymond E. Counsell - Ann Arbor MI Marc A. Longino - Ann Arbor MI Jamey P. Weichert - Ann Arbor MI Susan P. Schwendner - Ann Arbor MI
Assignee:
The University of Michigan - Ann Arbor MI
International Classification:
A61K 4902 C11C 302
US Classification:
424 11
Abstract:
Novel iodinated arylaliphatic triglyceride analogs, as radiologic agents are liver and hepatocyte site-specific. The triglyceride backbone structure is preferably 1,3-disubstituted or 1,2,3-trisubstituted with, in some embodiments, a 3-substituted-2,4,6-triiodophenyl aliphatic chain wherein the chain has a structure similar to naturally occurring fatty acids. In another embodiment, a monoiodophenyl aliphatic chain is utilized. Any position remaining on the triglyceride backbone is substituted with a saturated or unsaturated aliphatic hydrocarbon chain of the type found in naturally occurring fatty acids. The triglyceride analogs can be radioiodinated. In a preferred embodiment, a lipid emulsion is provided as the carrier vehicle.
Radioiodinated Phospholipid Ether Analogues And Methods Of Using Same
Raymond E. Counsell - Ann Arbor MI Karen L. Meyer - Norman OK Susan W. Schwendner - Ann Arbor MI Terushi Haradahira - Fukuoka, JP
Assignee:
The Board of Regents of The University of Michigan - Ann Arbor MI
International Classification:
C07F 909
US Classification:
558169
Abstract:
Novel radioiodinated analogues of naturally-occurring phospholipid ethers are tumor-specific and have a triglycerol backbone structure which, in certain embodiments, is substituted at the 3-position with an alkyl phosphocholine and include a monoiodinated benzoyl side chain substituted at the 2-position in accordance with the general formula: ##STR1## where n= 1-15 ##STR2## m= 0-15; Z=. sup. 123 I,. sup. 125 I, and. sup. 131 I; Y=NH. sub. 2, NR. sub. 2, and NR. sub. 3, and R=alkyl, aralkyl.