Suzanne Walker

US Patent:

6699836, Mar 2, 2004

Filed:

Mar 28, 2001

Appl. No.:

09/818787

Inventors:

Daniel Kahne - Princeton NJ
Suzanne Walker - Princeton NJ

Assignee:

The Trustees of Princeton University - Princeton NJ

International Classification:

C07G 1100

US Classification:

514 7, 514 1, 514 8, 514 23, 530322, 536 168

Abstract:

Compounds that are vancomycin analogs bearing terminal carboxyl group modifications as well as modifications to the vancosamine nitrogen and, optionally, modifications to the C6 position of the glucose residue attached to the amino acid four of the vancomycin heptapeptide chain are disclosed. Methods of making the compounds and methods of using the compounds to treat a bacterial infection in a host are also disclosed.

US Patent:

6921653, Jul 26, 2005

Filed:

Apr 9, 2001

Appl. No.:

09/829275

Inventors:

Suzanne Walker - Princeton NJ, US
Sha Ha - Princeton NJ, US

Assignee:

Princeton University - Princeton NJ

International Classification:

C12N009/10

US Classification:

435193

Abstract:

The present invention relates to crystals of the MurG, a membrane-associated UDP-glycosyltransferase involved in peptidoglycan biosynthesis. The present invention also relates to three-dimensional atomic coordinates of the MurG protein, three-dimensional structures of the protein, and images thereof. The present invention relates to methods of crystallizing MurG proteins.

US Patent:

20040110665, Jun 10, 2004

Filed:

Feb 11, 2003

Appl. No.:

10/361603

Inventors:

Daniel Kahne - Princeton NJ, US
Suzanne Walker - Princeton NJ, US
Domingos Silva - King of Russia PA, US

International Classification:

A61K038/14
C07K009/00

US Classification:

514/008000, 530/322000

Abstract:

Compounds that are analogs of glycopeptide antibiotics are disclosed. The compounds have the formula A-A-A-A-A-A-Awherein each of the groups Ato Ais a modified or unmodified -amino acid residue, Ais optional and, when present, is an organic group other than N-substituted leucine, and at least one of the groups Ato Ais linked via a glycosidic bond to one or more glycosidic groups each having one or more sugar residues, wherein at least one of said sugar residues is modified to bear at least one hydrophobic substituent. Methods of making these compounds, compositions including these compounds, and methods of using the compounds to treat infections in a host are also disclosed.

US Patent:

6518243, Feb 11, 2003

Filed:

Mar 31, 2000

Appl. No.:

09/540761

Inventors:

Daniel Kahne - Princeton NJ
Suzanne Walker - Princeton NJ

Assignee:

Trustees of Princeton University - Princeton

International Classification:

A61K 3814

US Classification:

514 8, 530322, 530343

Abstract:

Compounds that are analogs of glycopeptide antibiotics are disclosed. The compounds have the formula A -A -A -A -A -A -A wherein each of the groups A to A is a modified or unmodified -amino acid residue, A is optional and, when present, is an organic group other than N-substituted leucine, and at least one of the groups A to A is linked via a glycosidic bond to one or more glycosidic groups each having one or more sugar residues, wherein at least one of said sugar residues is modified to bear at least one hydrophobic substituent. Methods of making these compounds, compositions including these compounds, and methods of using the compounds to treat infections in a host are also disclosed.