Syed I Ahmed

US Patent:

6503556, Jan 7, 2003

Filed:

Dec 28, 2000

Appl. No.:

09/751691

Inventors:

Sameer Harish - Fremont CA
Steven Wu - Santa Clara CA
Deborra Sanders Millare - San Jose CA
Judy Guruwaiya - San Jose CA
Stephen Pacetti - San Jose CA
Syed Faiyaz Ahmed Hossainy - Fremont CA

Assignee:

Advanced Cardiovascular Systems, Inc. - Santa Clara CA

International Classification:

B05D 136

US Classification:

427 224, 427 225, 427 228, 427 23, 427553, 427554, 427555, 427556, 427258, 427261, 427287, 4274071, 427409

Abstract:

Methods of forming a coating onto an implantable device or endoluminal prosthesis, such as a stent, are provided. The coating may be used for the delivery of an active ingredient. The coating may have a selected pattern of interstices for allowing a fluid to seep through the coating in the direction of the pattern created.

US Patent:

6660034, Dec 9, 2003

Filed:

Apr 30, 2001

Appl. No.:

09/846498

Inventors:

Evgenia Mandrusov - Campbell CA
Paul Consigny - Morgan Hill CA
Syed Faiyaz Ahmed Hossainy - Fremont CA
Dary Mirzaee - Sunnyvale CA

Assignee:

Advanced Cardiovascular Systems, Inc. - Santa Clara CA

International Classification:

A61F 206

US Classification:

623 142

Abstract:

An implantable stent for a vessel includes a tubular body having an inner and outer surface. The inner and outer surfaces are coated with therapeutic substances. The therapeutic substance of the inner surface, such as an angiogenic substance, can be released downstream in the lumen. The therapeutic substance of the outer surface can be applied to the inner surface of the vessel.

US Patent:

6712845, Mar 30, 2004

Filed:

Apr 24, 2001

Appl. No.:

09/841798

Inventors:

Syed Faiyaz Ahmed Hossainy - Fremont CA

Assignee:

Advanced Cardiovascular Systems, Inc. - Santa Clara CA

International Classification:

A61F 206

US Classification:

623 142

Abstract:

A coating for a stent and methods for coating a stent are provided. The coating may be used for the sustained delivery of an active ingredient or a combination of active ingredients.

US Patent:

7297758, Nov 20, 2007

Filed:

Aug 2, 2005

Appl. No.:

11/195974

Inventors:

David C. Gale - San Jos CA, US
Syed Faiyaz Ahmed Hossainy - Fremont CA, US
Bin Huang - Shoreview MN, US
Klaus Kleine - Los Gatos CA, US

Assignee:

Advanced Cardiovascular Systems, Inc. - Santa Clara CA

International Classification:

C08F 6/00

US Classification:

528480, 2641761, 264219, 424422, 424426, 528481, 606108, 623 115

Abstract:

This invention relates to a method of extending the shelf-life of constructs, in particular bioabsorbable stents, comprising semi-crystalline polymers by increasing the crystallinity of the polymers.

US Patent:

7396541, Jul 8, 2008

Filed:

Sep 15, 2005

Appl. No.:

11/228420

Inventors:

Syed Faiyaz Ahmed Hossainy - Fremont CA, US
Ni Ding - San Jose CA, US

Assignee:

Advanced Cardiovascular Systems, Inc. - Santa Clara CA

International Classification:

A61F 2/00

US Classification:

424423

Abstract:

A prodrug comprising a heparin and a drug is provided. The prodrug can be used to form a coating on a medical device. The prodrug can also be used with a polymeric material to form a coating on a medical device. The polymeric material can be a hydrophobic polymer, a hydrophilic polymer, a non-fouling polymer, or combinations thereof. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

US Patent:

7419504, Sep 2, 2008

Filed:

Dec 27, 2004

Appl. No.:

11/023837

Inventors:

Syed Faiyaz Ahmed Hossainy - Fremont CA, US

Assignee:

Advanced Cardiovascular Systems, Inc. - Santa Clara CA

International Classification:

A61K 9/16
A61K 47/48
C08G 69/44
A61L 31/16
A61L 31/10

US Classification:

623 142, 424 7808, 424 783, 424422, 424423, 424457, 424451, 424489, 424490, 623 115, 623 146, 606 1

Abstract:

Provided herein is a copolymer that includes a soft block (A) that contains poly(ester amide) (PEA) and a hard block (B). The copolymer can be any of AB, ABA or BAB type block copolymers. By varying the relative amount of the PEA block and the hard block, one can obtain a copolymer with a Tfor mechanical integrity in drug-delivery stent applications. The copolymer can be used alone or optionally in combination with a biobeneficial material and/or a biocompatible polymer to form an implantable device or a coating on an implantable device. When the copolymer is used in combination with a biobeneficial material, the copolymer and the biobeneficial material can be co-deposited or applied in sequence during the coating process. A coating formed of the copolymer may also include a bioactive agent. The implantable device can be implanted in a patient to treat, prevent, or ameliorate a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, and/or tumor obstruction.

US Patent:

7511103, Mar 31, 2009

Filed:

Aug 5, 2008

Appl. No.:

12/186415

Inventors:

Syed Faiyaz Ahmed Hossainy - Fremont CA, US

Assignee:

Advanced Cardiovascular Systems, Inc. - Santa Clara CA

International Classification:

C08G 69/00
C08G 69/44

US Classification:

525411, 525415, 525420, 525425, 525432, 525434

Abstract:

Provided herein is a copolymer that includes a soft block (A) and a hard block (B) comprising a tyrosine di-peptide. The copolymer can be any of AB, ABA or BAB type block copolymers. The soft block can include a PEA polymer.

US Patent:

7563780, Jul 21, 2009

Filed:

Jun 18, 2004

Appl. No.:

10/871658

Inventors:

Syed Faiyaz Ahmed Hossainy - Fremont CA, US
Ni Ding - San Jose CA, US

Assignee:

Advanced Cardiovascular Systems, Inc. - Santa Clara CA

International Classification:

C08B 37/10
A61K 31/727
A61P 7/02

US Classification:

514 56, 536 21

Abstract:

A prodrug comprising a heparin and a drug is provided. The prodrug can be used to form a coating on a medical device. The prodrug can also be used with a polymeric material to form a coating on a medical device. The polymeric material can be a hydrophobic polymer, a hydrophilic polymer, a non-fouling polymer, or combinations thereof. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.