Marvin J. Slepian - Tucson AZ Daniel Yachia - Herzlia-on-Sea, IL Syed Hossainy - Fremont CA Baruch Levy - Ramat-Gan, IL Zeev Sohn - Ginot Shomron, IL
Assignee:
Harmonia Medical Technologies, Inc. - Rosh Haâ²Ayin
International Classification:
A61M 2500
US Classification:
604267, 606171, 606180
Abstract:
A process has been developed to reduce or relieve prostatic obstruction. The steps involved in the TUVOR Process include: 1. Transurethral Incision; 2. De-bulking and Intra-Prostatic Volume Reduction; 3. Intra-prostatic void exclusion and space filling with adhesive and/or therapeutic polymeric materials, alone or in combination with bioactive agents and/or mechanical means for closure; 4. Endourethral compression and prostatic mass remolding; 5. Endourethral Polymer Liner Layer. This liner formed from structurally supportive, yet eventually biodegradable, polymers further bolsters and supports the urethra and peri-urethral tissue during healing, eliminating the need for post-procedure catheter drainage. This step may be optional in specific clinical circumstances. The process is designed to allow outpatient treatment under local anesthesia for BPH.
Agents That Stimulate Therapeutic Angiogenesis And Techniques And Devices That Enable Their Delivery
Evgenia Mandrusov - Campbell CA Murthy V. Simhambhatla - San Jose CA Syed Hossainy - Fremont CA Eugene T. Michal - San Francisco CA Charles Claude - Santa Clara CA Jessica G. Chiu - Belmont CA
Assignee:
Advanced Cardiovascular Systems, Inc. - Santa Clara CA
International Classification:
A61B 812
US Classification:
600439
Abstract:
A method including positioning a catheter at a location in a blood vessel; imaging a thickness of a portion of a wall of the blood vessel at the location; identifying a treatment site; advancing a needle a distance into the wall of the blood vessel to the treatment site; and introducing a treatment agent through the needle to the treatment site. A composition including an inflammation-inducing agent and a carrier in the form of microspheres having a particle size suitable for transvascular delivery. A composition including a therapeutic angiogenesis promoter in a carrier and an opsonin-inhibitor coupled to the carrier. An apparatus for delivery of a therapeutic angiogenesis promoter.
Syed Hossainy - Fremont CA Fuh-Wei Tang - Temecula CA Brian P. Cahill - San Francisco CA
Assignee:
Advanced Cardiovascular Systems, Inc. - Santa Clara CA
International Classification:
A61F 208
US Classification:
623 115, 427 225, 623 139
Abstract:
A stent of variable surface area as determined by stent struts. The stent can have a variable surface area per unit length which accommodates a therapeutic agent. A patterned distribution of therapeutic agent can be provided throughout the stent. The stent can have an increased level of therapeutic agent near an end of the stent. A decreased level of therapeutic agent can be provided near an end of one embodiment of a stent. Indentations can be provided at the surface of the stent with therapeutic agent disposed therein. The stent can be cut with struts of variable thickness to provide the variable stent surface area.
Debra A. Timm - Foothill Ranch CA Henry K. Hui - Laguna Niguel CA Mark B. Roller - North Brunswick NJ Mora C. Melican - Bridgewater NJ Syed Hossainy - Fremont CA
The invention provides a method for single-step surface modification, grafting and sterilization for bio-active coating on materials and biomaterials used in medical devices, such as catheters, tissue engineering scaffolds, or drug delivery carrier materials. This may include any medical device or implantable that could benefit from improved antithrombogenic and biocompatible surfaces. Other relevant device examples may include heparin or urokinase coated stents to reduce clotting and restenosis, dental or ophthamological implants. These materials may be comprised of a variety of polymeric compositions such as, polyurethane, polyester, polytetrafluoroethylene, polyethylene, polymethylmethacrylate, polyHEMA, polyvinyl alcohol, polysiloxanes, polylactic or glycolic acids, polycaprolactone, etc. The substrates can also be metal, ceramics or biologically derived materials.
Steven Z. Wu - Santa Clara CA Sameer Harish - Fremont CA Judy A. Guruwaiya - San Jose CA Daryush Mirzaee - Sunnyvale CA Syed Hossainy - Fremont CA Charlene Chen - Redondo Beach CA
Assignee:
Advanced Cardiovascular Systems, Inc. - Santa Clara CA
An implantable medical device, such as a stent or graft, having asperities on a designated region of its outer surface is disclosed. The asperities can serve to improve retention of one or more layers of a coating on the device and to increase the amount of coating that can be carried by the device. The asperities can be formed by using a stream of pressurized grit to roughen the surface. The asperities can also be formed by removing material from the outer surface, for example, by chemical etching with or without a patterned mask. Alternatively, the asperities can be formed by adding material to the outer surface, for example, by welding powder particles to the outer surface or sputtering.
James Hong - San Jose CA, US Rahul Bhagat - San Jose CA, US Syed Hossainy - Fremont CA, US Santosh Prabhu - San Jose CA, US Ashok Shah - San Jose CA, US Srinivasan Sridharan - Morgan Hill CA, US
Assignee:
Advanced Cardiovascular Systems, Inc. - Santa Clara CA
A hybrid stent is formed which exhibits both high flexibility and high radial strength. The expandable hybrid stent for implantation in a body lumen, such as a coronary artery, consists of radially expandable cylindrical rings generally aligned on a common longitudinal axis and interconnected by one or more links. In one embodiment, a dip-coated covered stent is formed by encapsulating cylindrical rings within a polymer material. In other embodiments, at least some of the rings and links are formed of a polymer material which provides longitudinal and flexural flexibility to the stent. These polymer rings and links are alternated with metallic rings and links in various configurations to attain sufficient column strength along with the requisite flexibility in holding open the target site within the body lumen. Alternatively, a laminated, linkless hybrid stent is formed by encapsulating cylindrical rings within a polymer tube.
Syed Hossainy - Fremont CA, US Daryush Mirzaee - Sunnyvale CA, US
Assignee:
Advanced Cardiovascular Systems, Inc. - Santa Clara CA
International Classification:
A61F002/06
US Classification:
623 111, 623 146, 623 115
Abstract:
An implantable medical device, such as a stent, having roughened areas on an inner surface of the device for enhancing frictional contact between the medical device and a delivery system, such as a balloon catheter to secure the medical device to the delivery system during delivery of the medical device to a body lumen of a patient. Various methods for forming the roughened areas are also provided. The roughened areas may be coated with a material, such as a non-thrombogenic material, to enhance the compatibility of the inner surface of the medical device with fluid flowing through the vessel lumen of the patient.