Sylvia Kim

US Patent:

20030224420, Dec 4, 2003

Filed:

Apr 4, 2003

Appl. No.:

10/407435

Inventors:

Marc Hellerstein - Kensington CA, US
Sylvia Kim - Sunnyvale CA, US

International Classification:

C12Q001/68
G01N033/53
G01N033/567
G01N033/574
C12N005/08

US Classification:

435/006000, 435/007200, 435/007230, 435/366000

Abstract:

This invention relates to a method for separating long-term label retaining cells or stem cells. In particular, this invention relates to a method for separating long-term label retaining cells and/or stem cells from tissues or individuals and for measuring proliferation rates of long-term label retaining cells and stem cells, as well as determining clonal expansion (proliferative history) of cell lineages from the tissues of the individual. The cells may be double-labeled with a cell-lineage marking label and isotopically labeled DNA synthesis precursor prior to physical separation.

US Patent:

20090048174, Feb 19, 2009

Filed:

Dec 7, 2007

Appl. No.:

11/999806

Inventors:

Sylvia Jeewon Kim - San Jose CA, US

International Classification:

A61K 38/08
A61K 38/00
A61K 38/10
A61P 35/00

US Classification:

514 13, 514 2, 514 15, 514 17

Abstract:

Treatment methods for inhibiting tumor growth and angiogenesis are described. The methods involve treatment with an inhibitor of delta protein kinase C (δPKC) or an inhibitor of beta-II protein kinase C (βPKC), in an amount effective to decrease the rate of growth of a solid tumor and/or to inhibit tumor angiogenesis.