Taebo Sim

US Patent:

7449582, Nov 11, 2008

Filed:

Oct 8, 2004

Appl. No.:

10/961646

Inventors:

Qiang Ding - San Diego CA, US
Yongping Xie - San Diego CA, US
Nathanael S. Gray - San Diego CA, US
Shuli You - San Diego CA, US
Greg Chopiuk - San Diego CA, US
Jiqing Jiang - San Diego CA, US
Yi Liu - San Diego CA, US
Ruo Steensma - La Jolla CA, US
Xing Wang - San Diego CA, US
Taebo Sim - San Diego CA, US

Assignee:

IRM LLC - Hamilton

International Classification:

C07D 215/38
C07D 471/02
C07D 251/38

US Classification:

546153, 546157, 546123, 544224, 5142641, 514299

Abstract:

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, CSK, JNK1, JNK2, PDGF-R, p38, p70S6K, TGFβ, SRC, EGFR, c-Kit, trkB, FGFR3, Fes, Lck, Syk, RAF, MKK4, MKK6 and SAPK2β kinases.

US Patent:

7745437, Jun 29, 2010

Filed:

Jun 9, 2005

Appl. No.:

11/628881

Inventors:

Pingda Ren - San Diego CA, US
Xia Wang - San Diego CA, US
Guobao Zhang - San Diego CA, US
Qiang Ding - San Diego CA, US
Shuli You - Shanghai, CN
Qiong Zhang - San Diego CA, US
Greg Chopiuk - San Diego CA, US
Pamela A. Albaugh - Carlsbad CA, US
Taebo Sim - San Diego CA, US
Nathanael Schiander Gray - Boston MA, US

Assignee:

IRM LLC - Hamilton

International Classification:

C07D 403/04
A61K 31/4178

US Classification:

5142358, 514249, 51425202, 51425405, 514256, 544122, 544238, 544295, 544328

Abstract:

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, PDGF-R, trkB, c-SRC, BMX, FGFR3, b-RAF, ΣΓK, Tιε2, Λχκ, θNK2α2, MKK4, c-RAF, MKK6, SAPK2α and SAPK2β kinases.

US Patent:

7968557, Jun 28, 2011

Filed:

Feb 14, 2005

Appl. No.:

10/589099

Inventors:

Ha-Soon Choi - San Diego CA, US
Zhicheng Wang - San Diego CA, US
Nathanael Schiander Gray - Boston MA, US
Xiaohui He - San Diego CA, US
Yun He - San Diego CA, US
Tao Jiang - San Diego CA, US
Yi Liu - San Diego CA, US
Wendy Richmond - San Diego CA, US
Taebo Sim - Chestnut Hill MA, US
Kunyong Yang - San Diego CA, US

Assignee:

Novartis AG - Basel

International Classification:

C07D 487/04
A61K 31/519
A61P 35/00
A61P 37/06

US Classification:

5142651, 544280, 544279, 5142641

Abstract:

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the FAK, Abl, BCR-Abl, PDGF-R, c-Kit, NPM-ALK, Flt-3, JAK2 and c-Met kinases.

US Patent:

7371750, May 13, 2008

Filed:

Jul 29, 2004

Appl. No.:

10/909227

Inventors:

Taebo Sim - San Diego CA, US
Hyun Soo Lee - San Diego CA, US
Pingda Ren - San Diego CA, US
Qiang Ding - San Diego CA, US
Guobao Zhang - San Diego CA, US
Yi Liu - San Diego CA, US
Xia Wang - San Diego CA, US
Tetsuo Uno - San Diego CA, US
Bing Li - San Diego CA, US
Lintong Li - San Diego CA, US
Nathanael Schiander Gray - San Diego CA, US
Shuli You - San Diego CA, US

Assignee:

IRM LLC - Hamilton

International Classification:

A61K 31/5355
A61K 31/53
A61K 31/497
A61K 31/513
C07D 413/12
C07D 253/065
C07D 487/04
C07D 413/14
A61P 35/00
C07D 471/04

US Classification:

5142342, 514242, 51425216, 5142621, 544112, 544118, 544182, 544256, 544279, 544 81

Abstract:

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, Bmx, c-Raf, Csk, Fes, FGFR, Flt3, Ikk, IR, JNK, Lck, Mkk, PKC, PKD, Rsk, SAPK, Syk, Trk, BTK, Src, EGFR, IGF, Mek, Ros and Tie2 kinases.

US Patent:

8183248, May 22, 2012

Filed:

May 10, 2006

Appl. No.:

11/914308

Inventors:

Advait Nagle - San Diego CA, US
Nathanael Schiander Gray - Boston MA, US
Yi Liu - San Diego CA, US
Pingda Ren - San Diego CA, US
Taebo Sim - San Diego CA, US
Shuli You - Shanghai, CN

Assignee:

IRM LLC - Hamilton

International Classification:

C07D 487/04
A61K 31/519

US Classification:

5142651, 544280, 544122, 51425216, 5142328

Abstract:

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of Abl, Bcr-Abl, Bmx, BTK, b-RAF, c RAF, CSK, cSRC, Fes, FGFR3, Flt3, IKKα, IKKβ, JNK1α1, JNK2α2, Lck, Met, MKK4, MKK6, p70S6K, PAK2, PDGFRα, PKA, PKCα, PKD2, ROCK-II, Ros, Rsk1, SAPK2α, SAPK2β, SAPK3, SAPK4, SGK, Syk, Tie2 and TrkB kinases.

US Patent:

20050014753, Jan 20, 2005

Filed:

Apr 1, 2004

Appl. No.:

10/817328

Inventors:

Qiang Ding - San Diego CA, US
Taebo Sim - San Diego CA, US
Guobao Zhang - San Diego CA, US
Francisco Adrian - San Diego CA, US
Nathanael Gray - San Diego CA, US

Assignee:

IRM LLC - Hamilton HM LX

International Classification:

A61K031/53
A61K031/505

US Classification:

514241000, 514256000, 514340000, 544209000, 544319000, 544326000

Abstract:

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated tyrosine kinase activity, particularly diseases associated with the activity of PDGF-R, c-Kit and Bcr-abl.

US Patent:

20080113986, May 15, 2008

Filed:

Jun 23, 2005

Appl. No.:

11/570661

Inventors:

Pingda Ren - San Diego CA, US
Xia Wang - San Diego CA, US
Nathanael Gray - Boston MA, US
Yi Liu - San Diego CA, US
Taebo Sim - Chestnut Hill MA, US

Assignee:

IRM LLC - Hamilton

International Classification:

A61K 31/585
A61K 31/50
C07D 475/00

US Classification:

514234500, 514249000, 544118000, 544258000

Abstract:

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders than involve abnormal activation of the Abl, Bcr-abl, Bmx, c-RAF, CSK, Fes, FGFR3, Flt3, GSK3β, IR, JNK1α 1, JNK2α 2, Lck, MKK4, MKK6, p70S6K, PDGFRα, Rsk1, SAPK2α, SAPK2β, Syk and Trkβ kinases.

US Patent:

20090069327, Mar 12, 2009

Filed:

Feb 6, 2007

Appl. No.:

12/162313

Inventors:

Qiang Ding - San Diego CA, US
Pingda Ren - San Diego CA, US
Qiong Zhang - San Diego CA, US
Xia Wang - San Diego CA, US
Taebo Sim - San Diego CA, US
Pamela A. Albaugh - Carlsbad CA, US
Nathanael S. Gray - Boston MA, US

Assignee:

IRM LLC - Hamilton

International Classification:

A61K 31/5377
C07D 403/14
C07D 413/14
A61K 31/444
A61P 43/00
C07D 239/42
A61K 31/497

US Classification:

5142358, 544295, 544122, 544322, 544296, 51425218, 514256

Abstract:

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, Bmx, b-RAF, c-RAF, c-SRC, KDR, CSK, FGFR3, JAK2, Lck, Met, PKCα, SAPK2α, Tie2, TrkB and P70S6K kinases.