Taylor M Reid

US Patent:

7459302, Dec 2, 2008

Filed:

Oct 1, 2002

Appl. No.:

10/261751

Inventors:

Taylor Reid - Carlsbad CA, US
Roger Taylor - San Diego CA, US
Larry Brown - Carlsbad CA, US

Assignee:

Stratagene California - La Jolla CA

International Classification:

C12M 1/38

US Classification:

4352861, 4353031, 435809, 435 912, 4352887, 422 99, 422104, 165206

Abstract:

The invention relates to an apparatus and methods for preventing condensation on the interior surfaces of sample tubes which are being exposed to temperature cycles, such as during a PCR amplification reaction. In particular, the invention relates to apparatus comprising a sample block comprising a plurality of sample wells for receiving sample tubes and heating elements disposed in the sample wells for heating at least a portion of the sides of sample tubes (e. g. , at least the portion which forms the head space after a tube is filled with a PCR reaction mixture). In a preferred aspect, the sample block is part of a thermocycling device for performing PCR and the side-wall heater is used to enhance uniformity and speed of amplification reactions. For example, by decreasing or eliminating condensation, signal strength jumps in a real-time PCR assay can be minimized as can reaction non-homogeneity.

US Patent:

7608841, Oct 27, 2009

Filed:

Jun 12, 2006

Appl. No.:

11/451903

Inventors:

Taylor A. Reid - Carlsbad CA, US
Roger H. Taylor - San Diego CA, US
Kenneth J. Zajac - San Diego CA, US

Assignee:

Stratagene California - La Jolla CA

International Classification:

G01N 21/64

US Classification:

2504611

Abstract:

A system and method for fluorescence excitation and detection having distinct optical paths is disclosed. A system for detecting fluorescence comprises a light source that emits an excitation light into an illumination tube; a plurality of collection optics located around an aperture in the illumination tube for collecting fluorescence; and a detector for determining the amount of fluorescence. A method for detecting fluorescence comprises emitting an excitation light from a light source into an illumination tube; directing the excitation light to an excitation filter; illuminating a sample with the excitation light to generate an emission light; and detecting the optical characteristics of the emission light using a plurality of collection optics located around the illumination tube.

US Patent:

20060289786, Dec 28, 2006

Filed:

May 2, 2006

Appl. No.:

11/416886

Inventors:

Roger Taylor - San Diego CA, US
Taylor Reid - Carlsbad CA, US
Howard Choi - San Diego CA, US

International Classification:

G01N 21/64
G01J 3/30

US Classification:

250458100, 356318000, 356417000

Abstract:

A system and method for a pulsed light source used in detecting fluorescence from a plurality of samples of biological material discretely, continuously or intermittently during thermal cycling of DNA to accomplish a polymerase chain reaction (PCR). An apparatus for sampling at least one sample of a biological material comprises a light source that emits a pulsed excitation light that interacts with the sample and a detector sensitive to fluorescence emitted from the sample. A method of sampling at least one sample to detect fluorescence comprises generating a pulsed excitation light with a pulsed light source; directing the pulsed excitation light into the sample; illuminating a sample with the pulsed excitation light to generate an emission light; and detecting the optical characteristics of the emission light.

US Patent:

20070194247, Aug 23, 2007

Filed:

Aug 25, 2006

Appl. No.:

11/510520

Inventors:

Taylor Reid - Carlsbad CA, US
Roger Taylor - San Diego CA, US

International Classification:

G01J 1/58
G01T 1/10
H01L 31/14
H01J 40/14
F21V 9/16

US Classification:

250458100, 250459100, 250578100, 250553000

Abstract:

A compact optical module for fluorescence excitation and detection and methods for using same are disclosed. An apparatus for detecting fluorescence includes a substrate base, a detector adjacent to the substrate base for determining the amount of fluorescence, an emission filter adjacent to the detector, a light source for emitting an excitation light, the light source engaging the emission filter, and a cover formed over the detector, the emission filter, and the light source.

US Patent:

20200371029, Nov 26, 2020

Filed:

Jul 28, 2020

Appl. No.:

16/940947

Inventors:

- Indianapolis IN, US
Taylor Addison Reid - Carlsbad CA, US
Linda Marie Trondle - Irvine CA, US
Victoria Hung - San Diego CA, US
Yi Luo - Long Beach CA, US
Dennis Edwin Rieger - Hermosa Beach CA, US
Evan Phillip McMenamy - Los Alamitos CA, US
Nanditha Raghavan - Costa Mesa CA, US
Douglas John Canfield - Ludington MI, US
Elaine Grace Taine - Anaheim CA, US
Edsel Lawrence Noche Sinson - Chino Hills CA, US
Scott William Vande Wetering - Long Beach CA, US
Teri Taylor - Irvine CA, US
Travis Knox - Long Beach CA, US
Fran Zulo Cuaresma Jacaine - Anaheim CA, US
James Weston - Haddington, GB
Jennifer Bao-Guey Chan - San Francisco CA, US
Stephanie TuVi Ortega - Santa Ana CA, US
Rachel Sarah Schell - Torrance CA, US
Ronald Norman Diamond - Anaheim Hills CA, US
Steven Michael Gann - Huntington Beach CA, US
Eric Darnell Hall - Garden Grove CA, US
Tae Ho Hwang - Brea CA, US
John Lewis Morton - Canyon Lake CA, US
Anatoly Moskalev - Irvine CA, US
Marinela Gombosev Stack - San Clemente CA, US
Bruce Alan Sargeant - Orange CA, US
Michelle Fredrika Forshager - Vancouver WA, US
Vanessa Camille Chua - Chino Hills CA, US
Kylie Wilson - Indianapolis IN, US

International Classification:

G01N 21/64
G01N 35/10
G01N 33/53
G01N 33/543
G01N 33/58
G01N 33/68
G01N 35/00
G01N 21/76
G01N 33/569
G01N 33/564

Abstract:

A quantitative method for diagnosing an autoimmune disease or an infectious disease comprising performing an automated diagnostic assay, comprising: incubating a capture reagent with a streptavidin-coated medium to form a solid phase complex, wherein the capture reagent is a biotinylated autoantigen or infectious disease antigen; washing the solid phase complex to remove excess capture reagent; incubating the solid phase complex with a serum sample to form an immune complex; washing the immune complex to remove any unbound sample; incubating the immune complex with a conjugate to create an immune-conjugate complex; washing the immune-conjugate complex to remove any unbound conjugate; introducing a substrate capable of generating a quantifiable response; and calibrating the response generated from introducing the substrate.

US Patent:

20180231541, Aug 16, 2018

Filed:

Feb 7, 2018

Appl. No.:

15/890932

Inventors:

- Indianapolis IN, US
Taylor Reid - Carlsbad CA, US
Gerold Firl - Poway CA, US
Yohei Yamamuro - San Diego CA, US
Nathaniel Hague - Escondido CA, US

International Classification:

G01N 33/543
B01L 3/02
B01L 3/00
G01N 1/38
G01N 35/10

Abstract:

In an embodiment, an immunochemistry analysing system includes a source of paramagnetic particles, a source of fluid, a cuvette configured to receive the paramagnetic particles and the fluid, a pipette configured to (i) translate so that at least a portion of the pipette is located within the cuvette and (ii) dispense at least one of the paramagnetic particles and the fluid into the cuvette so that the paramagnetic particles and the fluid can be mixed within the cuvette, a motor configured to move the pipette while located in the cuvette, and a control unit configured to vary a motor drive of the motor to cause the pipette to mix the fluid with the paramagnetic particles within the cuvette.

US Patent:

20170212111, Jul 27, 2017

Filed:

Apr 7, 2017

Appl. No.:

15/482537

Inventors:

- Indianapolis IN, US
Taylor Addison Reid - Carlsbad CA, US
Linda Marie Trondle - Irvine CA, US
Victoria Hung - San Diego CA, US
Yi Luo - Long Beach CA, US
Dennis Edwin Rieger - Hermosa Beach CA, US
Evan Phillip McMenamy - Los Alamitos CA, US
Nanditha Raghavan - Costa Mesa CA, US
Douglas John Canfield - Ludington MI, US
Elaine Grace Taine - Anaheim CA, US
Edsel Lawrence Noche Sinson - Chino Hills CA, US
Scott William Vande Wetering - Long Beach CA, US
Teri Taylor - Irvine CA, US
Travis Knox - Long Beach CA, US
Fran Zylo Cuaresma Jacalne - Anaheim CA, US
James Weston - Haddington, GB
Jennifer Bao-Guey Chan - San Francisco CA, US
Stephanie TuVi Ortega - Santa Ana CA, US
Rachel Sarah Schell - Torrance CA, US
Ronald Norman Diamond - Anaheim Hills CA, US
Steve Michael Gann - Huntington Beach CA, US
Eric Darnell Hall - Garden Grove CA, US
Tae Ho Hwang - Brea CA, US
John Lewis Morton - Canyon Lake CA, US
Anatoly Moskalev - Irvine CA, US
Marinela Gombosev Stack - San Clemente CA, US
Bruce Alan Sargeant - Organe CA, US
Michelle Fredrika Forshager - Vancouver, CA
Vanessa Camille Chua - Chino Hills CA, US
Kylie Wilson - Indianapolis IN, US

International Classification:

G01N 33/569
G01N 21/76
G01N 33/58
G01N 21/64
G01N 33/564
G01N 33/53

Abstract:

A quantitative method for performing an automated diagnostic assay, comprising: incubating a capture reagent with a streptavidin-coated medium to form a solid phase complex; washing the solid phase complex to remove excess capture reagent; incubating the solid phase complex with a serum sample to form an immune complex; washing the immune complex to remove any unbound sample; incubating the immune complex with a conjugate to create an immune-conjugate complex; washing the immune-conjugate complex to remove any unbound conjugate; introducing a substrate capable of generating a quantifiable response; and calibrating the response generated from introducing the substrate.

US Patent:

20140274784, Sep 18, 2014

Filed:

Mar 17, 2014

Appl. No.:

14/215720

Inventors:

- Indianapolis IN, US
Taylor Addison Reid - Carlsbad CA, US
Linda Marie Trondle - Irvine CA, US
Victoria Hung - San Diego CA, US
Yi Luo - Long Beach CA, US
Dennis Edwin Rieger - Hermosa Beach CA, US
Evan Phillip McMenamy - Los Alamitos CA, US
Nanditha Raghavan - Costa Mesa CA, US
Douglas John Canfield - Ludington MI, US
Yiling Nie - Anaheim CA, US
Edsel Lawrence Noche Sinson - Chino Hills CA, US
Scott William Vande Wetering - Long Beach CA, US
Teri Taylor - Irvine CA, US
Travis Knox - Long Beach CA, US
Fran Zylo Cuaresma Jacalne - Anaheim CA, US
James Weston - Haddington, GB
Jennifer Bao-Guey Chan - San Francisco CA, US
Rachel Sarah Schell - Torrance CA, US
Ronald Norman Diamond - Anaheim Hills CA, US
Steve Michael Gann - Huntington Beach CA, US
Eric Darnell Hall - Garden Grove CA, US
Tae Ho Hwang - Brea CA, US
John Lewis Morton - Canyon Lake CA, US
Anatoly Moskalev - Irvine CA, US
Marinela Gombosev Stack - San Clemente CA, US
Bruce Alan Sargeant - Orange CA, US

International Classification:

G01N 33/564
G01N 33/543
G01N 33/68

US Classification:

506 9, 436501, 435 792

Abstract:

A quantitative method for performing an automated diagnostic assay, comprising: incubating a capture reagent with a streptavidin-coated medium to form a solid phase complex; washing the solid phase complex to remove excess capture reagent; incubating the solid phase complex with a serum sample to form an immune complex; washing the immune complex to remove any unbound sample; incubating the immune complex with a conjugate to create an immune-conjugate complex; washing the immune-conjugate complex to remove any unbound conjugate; introducing a substrate capable of generating a quantifiable response; and calibrating the response generated from introducing the substrate.