Teresa A Bennett

US Patent:

6943268, Sep 13, 2005

Filed:

Oct 31, 2002

Appl. No.:

10/284321

Inventors:

Snezna Rogelj - Socorro NM, US
Teresa A. Bennett - San Diego CA, US
Larry A. Sklar - Albuquerque NM, US

Assignee:

Science & Technology Corporation @ UNM - Albuquerque NM

International Classification:

C07C309/05

US Classification:

562 43

Abstract:

The invention provides anti-thiol reagents which inhibit enzyme activity of cell-associated protein disulfide isomerase (PDI) by oxidizing or blocking PDI active site vicinal thiol groups which normally participate in disulfide bond rearrangement of PDI substrates. Inhibition of this PDI function is particularly useful in blocking PDI-mediated entry of HIV or other virions into a host cell, as well as inhibiting lymphocyte traffic through the lymph nodes. The invention further provides an assay for the identification of such PDI inhibitors based on the discovery that inhibitors of the invention also induce shedding of the leucocyte L-selectin adhesion molecule. The invention additionally provides for suppression of inflammation and of lymph node entry by calmodulin antagonists that, like PDI inhibition, cause leukocyte L-selectin shedding.

US Patent:

7858040, Dec 28, 2010

Filed:

May 7, 2004

Appl. No.:

10/841810

Inventors:

Alex Okun - San Diego CA, US
Teresa A. Bennett - San Diego CA, US
Andrew Beernink - San Diego CA, US
David J. Sieg - Escondido CA, US
John T. Ransom - Encinitas CA, US

Assignee:

Saryna Biotechnologies LLC - San Diego CA

International Classification:

B01L 3/02

US Classification:

422100, 436 49, 7386401

Abstract:

A system and method of mixing and injecting discrete sample mixtures into a flow cytometer or other sample analysis apparatus may generally comprise a sample injection guide coupling a liquid handling apparatus with a sample analysis apparatus and facilitating injection of discrete sample mixtures into a fluidic system of the apparatus.

US Patent:

20050009060, Jan 13, 2005

Filed:

May 7, 2004

Appl. No.:

10/841410

Inventors:

Andrew Beernink - San Diego CA, US
Teresa Bennett - San Diego CA, US
Alex Okun - San Diego CA, US
Juan Ballesteros - San Diego CA, US
John Ransom - Encinitas CA, US

International Classification:

C12Q001/68
G01N001/30
G01N033/48

US Classification:

435006000, 435040500

Abstract:

The present disclosure provides systems for multiplexed multitarget screening of cell populations having one or more wild type or mutated ligand targets and measuring cell responses to ligands using high throughput screening techniques, including flow cytometry (FCM). The method includes the steps of: 1) developing cell populations to be screened; 2) staining cell populations using one or more fluorochromes to yield a distinct excitation/emission signature for each cell population; 3) combining labelled cell populations into a single mixed suspension; 4) analyzing populations to resolve them on the basis of their unique signature; and 5) resolving individual populations and deconvoluting data to extract meaningful information about populations.

US Patent:

20050021241, Jan 27, 2005

Filed:

May 7, 2004

Appl. No.:

10/841974

Inventors:

Juan Ballesteros - San Diego CA, US
Teresa Bennett - San Diego CA, US
Alex Okun - San Diego CA, US
Andrew Beernink - San Diego CA, US
John Ransom - Encinitas CA, US

International Classification:

G01N033/48

US Classification:

702021000

Abstract:

The present disclosure provides compositions and methods for high throughput Gain of Function (GOF) sorting to discover and develop novel and highly selective candidate drug molecules. High throughput GOF sorting includes: mutating a single residue in a receptor and/or ligand; measuring the affinity and functional activity of the resulting ligand target-ligand interaction; and carrying out multiple rounds of mutation and measurement to determine which residues provide key interaction points underlying the functional activity of a ligand target-ligand interaction. Further, the present disclosure provides methods and compositions for high throughput and high precision GOF sorting, such that large numbers of mutations can be generated and screened rapidly, and GOF compounds can be identified and isolated.

US Patent:

20080027072, Jan 31, 2008

Filed:

Apr 19, 2007

Appl. No.:

11/788748

Inventors:

Teresa Bennett - San Diego CA, US
James Hauske - La Jolla CA, US
Fu-Yue Zeng - Lakeland TN, US

Assignee:

AMPLA Pharmaceuticals, Inc. - La Jolla CA

International Classification:

A61K 31/496
A61K 31/4523
A61P 15/00
A61P 3/04

US Classification:

514253040, 514323000, 514789000

Abstract:

The present invention provides methods of treating obesity, eating disorders, and sexual dysfunction. The methods comprise administering to a mammalian host suffering from obesity, an eating disorder, or sexual dysfunction an effective dose of a compound of the invention. Also provided are methods of potentiating the effect of an MC4 receptor agonist in a mammalian host. In some cases the methods comprise administering to the host a compound that lowers the ECof the agonist. In other cases the methods comprise administering to the host a compound that increases the maximum effect of the agonist.

US Patent:

20080027087, Jan 31, 2008

Filed:

Feb 21, 2007

Appl. No.:

11/709311

Inventors:

Teresa Bennett - San Diego CA, US
James Hauske - San Diego CA, US
Fu-Yue Zeng - Lake Land TN, US

Assignee:

AMPLA Pharmaceuticals, Inc. - La Jolla CA

International Classification:

A61K 31/4164
A61K 31/137
A61K 31/506
C07D 233/54
C07D 333/56
A61P 3/00
A61K 31/381

US Classification:

514269000, 514399000, 514443000, 514646000, 548341100, 549058000

Abstract:

The present invention relates to methods of treating obesity, anorexia nervosa, or bulimia nervosa comprising administering a compound of the invention. The present invention further relates to the treatment of metabolic syndrome comprising administering a compound of the invention.