Teresa L Gilbert

US Patent:

6495668, Dec 17, 2002

Filed:

May 3, 2000

Appl. No.:

09/564595

Inventors:

Teresa Gilbert - Seattle WA
Charles E. Hart - Woodinville WA
Paul O. Sheppard - Granite Falls WA
Debra G. Gilbertson - Seattle WA

Assignee:

ZymoGenetics, Inc. - Seattle WA

International Classification:

A61K 3824

US Classification:

530399, 435 694, 435 701, 530350, 536 234

Abstract:

Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.

US Patent:

6962802, Nov 8, 2005

Filed:

Jun 6, 2001

Appl. No.:

09/876813

Inventors:

Teresa Gilbert - Seattle WA, US
Charles E. Hart - Woodinville WA, US
Paul O. Sheppard - Granite Falls WA, US
Debra G. Gilbertson - Seattle WA, US

Assignee:

ZymoGenetics, Inc. - Seattle WA

International Classification:

C12N015/09
C12N015/00
C07H021/04
A61K038/24
A61K038/27

US Classification:

435 694, 435 691, 4353201, 530350, 530399, 536 2351, 536 231, 536 235

Abstract:

Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.

US Patent:

7323446, Jan 29, 2008

Filed:

Oct 17, 2006

Appl. No.:

11/550246

Inventors:

Teresa Gilbert - Seattle WA, US
Charles E. Hart - Woodinville WA, US
Paul O. Sheppard - Granite Falls WA, US
Debra G. Gilbertson - Seattle WA, US

Assignee:

ZymoGenetics, Inc. - Seattle WA

International Classification:

A61K 38/00
A61K 38/24
C07K 1/00
C12N 15/09
C12P 21/04

US Classification:

514 12, 530399, 530350, 435 694, 435 701, 435 691, 4241921, 4241981

Abstract:

Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.

US Patent:

7375182, May 20, 2008

Filed:

Mar 15, 2005

Appl. No.:

11/080803

Inventors:

Teresa Gilbert - Seattle WA, US
Charles E. Hart - Woodinville WA, US
Paul O. Sheppard - Granite Falls WA, US

Assignee:

ZymoGenetics, Inc. - Seattle WA

International Classification:

A61K 38/00
A61K 38/24
C12P 21/06
C07H 21/04

US Classification:

530324, 530399, 435 691, 536 235

Abstract:

Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.

US Patent:

7514238, Apr 7, 2009

Filed:

Oct 17, 2006

Appl. No.:

11/550237

Inventors:

Teresa Gilbert - Seattle WA, US
Charles E. Hart - Woodinville WA, US
Paul O. Sheppard - Granite Falls WA, US

Assignee:

ZymoGenetics, Inc. - Seattle WA

International Classification:

C12P 21/06
C12P 21/04
C12N 15/00
C12N 5/00
C07H 21/02
C07H 21/04
C07K 1/00

US Classification:

435 691, 435 701, 4353201, 435325, 536 231, 536 235, 530350

Abstract:

Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.

US Patent:

20020045733, Apr 18, 2002

Filed:

Jun 13, 2001

Appl. No.:

09/880578

Inventors:

Si Lok - Seattle WA, US
Scott Presnell - Seattle WA, US
Anna Jelmberg - Issaquah WA, US
Teresa Gilbert - Auburn WA, US
Theodore Whitmore - Redmond WA, US
Donald Foster - Lake Forest Park WA, US
Robyn Adams - Bellevue WA, US
Joyce Lehner - Seattle WA, US

Assignee:

ZymoGenetics, Inc.

International Classification:

C07K014/52
C07H021/04
C12P021/02
C12N005/06

US Classification:

530/350000, 536/023500, 530/351000, 435/069500, 435/325000, 435/320100

Abstract:

Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions. The polypeptides of the present invention can be used to down-regulate their natural ligands. The polynucleotides and subsequences thereof can be used as diagnostic probes to determine if chromosome 19 is mutated. The antibodies which bind to the polypeptides can be used to purify the receptors and to inhibit the binding of the ligands onto the receptors.

US Patent:

20040242850, Dec 2, 2004

Filed:

Jun 25, 2004

Appl. No.:

10/877623

Inventors:

Teresa Gilbert - Seattle WA, US
Charles Hart - Woodinville WA, US
Paul Sheppard - Granite Falls WA, US
Debra Gilbertson - Seattle WA, US

Assignee:

ZymoGenetics, Inc.

International Classification:

C07K016/46
C07K016/44

US Classification:

530/388150, 530/388220, 530/391100

Abstract:

Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.

US Patent:

20050131214, Jun 16, 2005

Filed:

Sep 17, 2004

Appl. No.:

10/943594

Inventors:

Teresa Gilbert - Seattle WA, US
Scott Presnell - Tacoma WA, US

International Classification:

C07K014/52

US Classification:

530351000

Abstract:

Novel mammalian zcyto7 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods including antibodies and anti-idiotypic antibodies.