Teresa Nien Ho

US Patent:

57982252, Aug 25, 1998

Filed:

May 24, 1995

Appl. No.:

8/449500

Inventors:

John L. Krstenansky - Palo Alto CA
John J. Nestor - Cupertino CA
Teresa H. Ho - Los Altos CA
Brian H. Vickery - Mountain View CA
Chinh T. Bach - San Jose CA

Assignee:

Syntex (U.S.A.) Inc. - Palo Alto CA

International Classification:

C12N 1516
C12N 121
C12N 1563

US Classification:

435 694

Abstract:

Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which amino acid residues (22-31) form an amphipathic. alpha. -helix, said residues (22-31) selected from hydrophilic amino acids (Haa) and lipophilic amino acids (Laa) ordered in the sequence: Haa(Laa Laa Haa Haa). sub. 2 Laa and their pharmaceutically acceptable salts are useful for the prophylaxis and treatment of ostoporosis in mammals. Processes for the production of the polypeptides via solid phase and recombinant methods are provided.

US Patent:

55894526, Dec 31, 1996

Filed:

Jul 14, 1992

Appl. No.:

7/915247

Inventors:

John L. Krstenansky - Palo Alto CA
John J. Nestor - Cupertino CA
Teresa H. Ho - Los Altos CA
Brian H. Vickery - Mountain View CA
Chinh T. Bach - San Jose CA

Assignee:

Syntex (U.S.A.) Inc. - Palo Alto CA

International Classification:

A61K 3829
C07K 14635

US Classification:

514 12

Abstract:

Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which amino acid residues (22-31) form an amphipathic. alpha. -helix, said residues (22-31) selected from hydrophilic amino acids (Haa) and lipophilic amino acids (Laa) ordered in the sequence: Haa(Laa Laa Haa Haa). sub. 2 Laa and their pharmaceutically acceptable salts are useful for the prophylaxis and treatment of ostoporosis in mammals. Processes for the production of the polypeptides via solid phase and recombinant methods are provided.

US Patent:

56959559, Dec 9, 1997

Filed:

May 23, 1995

Appl. No.:

8/448070

Inventors:

John L. Krstenansky - Palo Alto CA
John J. Nestor - Cupertino CA
Teresa H. Ho - Los Altos CA
Brian H. Vickery - Mountain View CA
Chinh T. Bach - San Jose CA

Assignee:

Syntex (U.S.A.) Inc. - Palo Alto CA

International Classification:

C12P 2106

US Classification:

435 694

Abstract:

Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which amino acid residues (22-31) form an amphipathic. alpha. -helix, these residues (22-31) selected from hydrophilic amino acids (Haa) and lipophilic amino acids (Laa) ordered in the sequence: Haa (Laa Laa Haa Haa). sub. 2 Laa and their pharmaceutically acceptable salts are useful for the prophylaxis and treatment of ostoporosis in mammals. Processes for the production of the polypeptides via solid phase and recombinant methods are provided.

US Patent:

58408371, Nov 24, 1998

Filed:

May 24, 1995

Appl. No.:

8/449447

Inventors:

John L. Krstenansky - Palo Alto CA
John J. Nestor - Cupertino CA
Teresa H. Ho - Los Altos CA

Assignee:

Syntex (U.S.A.) Inc. - Palo Alto CA

International Classification:

A61K 3829
C07K 1400

US Classification:

530324

Abstract:

Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which amino acid residues (22-31) form an amphipathic. alpha. -helix, said residues (22-31) selected from hydrophilic amino acids (Haa) and lipophilic amino acids (Laa) ordered in the sequence: Haa(Laa Laa Haa Haa). sub. 2 Laa and their pharmaceutically acceptable salts are useful for the prophylaxis and treatment of ostoporosis in mammals. Processes for the production of the polypeptides via solid phase and recombinant methods are provided.

US Patent:

58740864, Feb 23, 1999

Filed:

Jan 18, 1994

Appl. No.:

8/184328

Inventors:

John L. Krstenansky - Palo Alto CA
John J. Nestor - Cupertino CA
Teresa H. Ho - Los Altos CA
Brian H. Vickery - Mountain View CA
Chinh T. Bach - San Jose CA

Assignee:

Syntex (U.S.A,), Inc. - Palo Alto CA

International Classification:

A61K 3829

US Classification:

4241981

Abstract:

Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which amino acid residues (22-31) form an amphipathic. alpha. -helix, said residues (22-31) selected from hydrophilic amino acids (Haa) and lipophilic amino acids (Laa) ordered in the sequence: Haa(Laa Laa Haa Haa). sub. 2 Laa and their pharmaceutically acceptable salts are useful for the prophylaxis and treatment of ostoporosis in mammals. Processes for the production of the polypeptides via solid phase and recombinant methods are provided.

US Patent:

60516860, Apr 18, 2000

Filed:

May 23, 1995

Appl. No.:

8/447856

Inventors:

John L. Krstenansky - Palo Alto CA
John J. Nestor - Cupertino CA
Teresa H. Ho - Los Altos CA
Brian H. Vickery - Mountain View CA
Chinh T. Bach - San Jose CA

Assignee:

Syntex (U.S.A.) Inc. - Palo Alto CA

International Classification:

A61K 3800
C07K 1400
C07K 110

US Classification:

530333

Abstract:

Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which amino acid residues (22-31) form an amphipathic. alpha. -helix, said residues (22-31) selected from hydrophilic amino acids (Haa) and lipophilic amino acids (Laa) ordered in the sequence: Haa(Laa Laa Haa Haa). sub. 2 Laa and their pharmaceutically acceptable salts are useful for the prophylaxis and treatment of ostoporosis in mammals. Processes for the production of the polypeptides via solid phase and recombinant methods are provided.