Terry E Phillips

US Patent:

6969605, Nov 29, 2005

Filed:

Jul 16, 2001

Appl. No.:

09/906243

Inventors:

Charles W. Anderson - Woodbine MD, US
C. Brent Bargeron - Columbia MD, US
Richard C. Benson - Highland MD, US
Micah A. Carlson - Baltimore MD, US
Allan B. Fraser - Woodbine MD, US
John D. Groopman - Owings Mills MD, US
Harvey W. Ko - Ellicott City MD, US
David R. Kohler - Ellicott City MD, US
Terry E. Phillips - Ellicott City MD, US
Paul T. Strickland - Baltimore MD, US

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

C12M003/00

US Classification:

4352871, 2101982, 210656, 210659, 2504581, 2504591, 2504611, 2504621, 422 56, 422 69, 422 70, 4352872, 4352885, 4352887, 436161, 436172, 436518, 436529, 436530, 436531, 436534, 436536

Abstract:

A hand held, self-contained, automatic, low power and rapid sensor platform for detecting and quantifying a plurality of analytes. A sample solution potentially containing an unknown amount of an analyte is passed through an affinity column which contains antibodies to which the analyte binds thereby extracting the analyte. The affinity column is then rinsed to remove any other chemicals that may fluoresce. The rinsed affinity column is then eluted with a known volume of elution fluid causing the analyte to release from the antibody and dissolve in the fluid (eluant). The eluant is then placed in the quartz cuvette of a fluorometer. The analyte suspended in the eluant fluoresces at a waveband which is different than that of the light source that excites it. The amount of fluorescence is measured and the level of analyte determined. The rinsing and elution fluids, and/or the affinity column can be placed in a module for easy insertion and removal from the sensor when depleted or when the sensor is to be used against a different analyte.

US Patent:

7148706, Dec 12, 2006

Filed:

Jul 18, 2003

Appl. No.:

10/517364

Inventors:

Rengaswamy Srinivasan - Ellicott City MD, US
Hassan M. Saffarian - Silver Spring MD, US
Terry E. Phillips - Ellicott City MD, US

Assignee:

Johns Hopkins University - Baltimore MD

International Classification:

G01R 27/08

US Classification:

324700, 324693

Abstract:

An embeddable corrosion rate meter (ECRM) for detecting and measuring corrosion in metal and concrete structures is provided. The system comprises an electrochemical cell with at least one working electrode evenly separated from a counter electrode, wherein a separation distance between electrodes determines an electrolyte medium resistance and the electrolyte medium resistance is less than or equal to a polarization resistance. The system further includes a signal generator connected to a plurality of resistances for creating a plurality of current amplitudes for generating a current source; a first selector for applying a current through each of the plurality of resistances to the working electrode and counter electrode; a second selector for selecting a duration of a current pulse; a voltmeter/A-D converter having an input impedance >10ohms for measuring polarization of the working electrode; and an external reader-head with a data link and power link connected to a computing device for powering the system and collecting corrosion measurements data.

US Patent:

7554294, Jun 30, 2009

Filed:

Jan 28, 2005

Appl. No.:

11/045740

Inventors:

Rengaswamy Srinivasan - Ellicott City MD, US
Hassan M. Saffarian - Silver Spring MD, US
Terry E. Phillips - Ellicott City MD, US
Paul R. Zarriello - Catonsville MD, US
Bliss G. Carkhuff - Laurel MD, US
Subhas Chalasani - Troy MI, US

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

H02J 7/00
G01N 27/416

US Classification:

320132, 320128, 320136, 320145, 324426

Abstract:

A battery health monitor (BHM) that operates as a battery-mountable full-spectrum alternating current (ac) impedance meter that facilitates monitoring a state-of-charge and a state-of-health of a battery. The BHM is used for monitoring one or more electrical parameters, e. g. , impedance, of a battery. The BHM includes: a current sink coupled to the first terminal and configured to sink therefrom an oscillatory current so as to cause the battery to produce at a first terminal thereof an oscillatory voltage equal to or less than a dc operating voltage of the battery that would be present at the first terminal in the absence of the oscillatory current; and a voltage sensor configured to sense the oscillatory voltage at the first terminal.

US Patent:

20030211011, Nov 13, 2003

Filed:

Dec 4, 2002

Appl. No.:

10/311169

Inventors:

Terry Phillips - Ellicott City MD, US
Rengaswamy Srinivasan - Ellicott City MD, US
C. Bargeron - Columbia MD, US
Hassan Saffarian - Silver Spring MD, US
Elizabeth Schemm - Clarksville MD, US

International Classification:

G01N021/27

US Classification:

422/082050, 436/163000

Abstract:

A pH sensor system () and method capable of monitoring the pH level of a medium based on the characteristics of a chromatic pH sensitive material employed in the pH sensor system is provided. The pH sensor system includes at least a housing () having at least one transparent surface (); a light sensitive circuitry (), e.g., a LED () and photo-detector (), enclosed within the housing; and, a chromatic pH sensitive material () overlaying at least a portion of the transparent surface having the characteristic of becoming saturated when an ambient pH level reaches a predetermined level such that the light sensitive circuitry detects a different intensity of incident light when the chromatic pH sensitive material is saturated than when the chromatic pH sensitive material is not saturated. As the pH level of the medium, e.g., concrete, storage tanks containing chemical reagents, etc., to be monitored steadily decreases, the pH sensitive material on the transparent surface of the housing will gradually become saturated with hydrogen ions and colorless. When the pH level reaches the predetermined level, the pH sensitive material will be unable to absorb any light being emitted from the LED such that the light is reflected back to the photo-detector.

US Patent:

20050074900, Apr 7, 2005

Filed:

Jul 2, 2004

Appl. No.:

10/882188

Inventors:

Nicole Morgan - Bethesda MD, US
Michael Gaitan - North Potomac MD, US
Laurie Locascio - North Potomac MD, US
Terry Phillips - Washington DC, US
Thomas Pohida - Monrovia MD, US
Paul Smith - Annapolis MD, US

International Classification:

G01N033/558

US Classification:

436514000

Abstract:

Described are microfluidic devices for, preferably, high-throughput, multi-analyte, affinity capture and detection of affinity-bindable analytes in biological fluids. Particularly, the devices can be used for immunoassays of biological fluids using multiple antibodies for capture and detection of multiple analytes, including proteins. The devices can be used for the simultaneous isolation and quantization of multiple proteins from microliter samples of biological fluids. Also described are methods for detecting and, optionally, quantifying, affinity-bindable analytes in biological fluids using these devices.

US Patent:

20070287952, Dec 13, 2007

Filed:

Apr 27, 2007

Appl. No.:

11/741451

Inventors:

Jay Shah - Bethesda MD, US
Terry Phillips - Washington DC, US
Jerome Danoff - Bethesda MD, US
Lynn Gerber - Bethesda MD, US

International Classification:

A61M 31/00

US Classification:

604027000, 604028000

Abstract:

Provided are novel devices, systems, and methods for performing microanalysis of a localized biochemical milieu, and/or for highly localized drug delivery and treatment evaluation.

US Patent:

20120155507, Jun 21, 2012

Filed:

Oct 18, 2011

Appl. No.:

13/275664

Inventors:

Rengaswamy Srinivasan - Ellicott City MD, US
Michael H. Butler - Dayton MD, US
Bliss G. Carkhuff - Laurel MD, US
Terry E. Phillips - Ellicott City MD, US
Jeremy D. Walker - Washington DC, US
Oscar M. Uy - Baltimore MD, US
Andrew C. Baisden - Silver Spring MD, US

Assignee:

JOHNS HOPKINS UNIVERSITY - Baltimore MD

International Classification:

G01N 25/00

US Classification:

374 45

Abstract:

Methods and systems to determine an internal temperature of a rechargeable lithium-ion cell based on a phase shift of the cell. Internal cell temperature may be determined with respect to an internal anode temperature and/or an internal cathode temperature. Internal anode temperature may be determined based on a phase shift of a frequency within a range of approximately 40 Hertz (Hz) to 500 Hz. Internal cathode temperature may be determined based on a phase shift of a frequency of up to approximately 30 Hz. A temperature sensor as disclosed herein may be powered by a monitored cell with relatively little impact on cell charge, may be electrically coupled to cell but housed physically separate from the cell, and/or may monitor multiple cells in a multiplex fashion. A rate of change in phase shift may be used to initiate pre-emptive action, without determining corresponding temperatures.

US Patent:

20120236901, Sep 20, 2012

Filed:

Mar 14, 2012

Appl. No.:

13/419809

Inventors:

John A. Thomas - Ellicott City MD, US
Jason E. Tiffany - Columbia MD, US
Lawrence W. Hunter - Ellicott City MD, US
Terry E. Phillips - Ellicott City MD, US

Assignee:

THE JOHNS HOPKINS UNIVERSITY - Baltimore MD

International Classification:

G01K 3/04

US Classification:

374102, 374E03004

Abstract:

A time-temperature indication device includes a first reservoir having a fluid disposed therein, and a capillary tube. The capillary tube is disposed proximate to the first reservoir to receive fluid from the first reservoir responsive to changes in viscosity of the fluid based on changes in temperature. The capillary tube restricts flow of the fluid out of the first reservoir into the capillary tube to enable fluid flow only in a single direction.