The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula I; wherein X, Y, Z, D and R are as defined in the specification.
8-Azaprostaglandin Carbonate And Thiocarbonate Analogs As Therapeutic Agents
The present invention provides a compound represented by the general formula I; wherein A, Ar, X, Z, n, x, y, R and R are as defined in the specification.
8-Azaprostaglandin Carbonate And Thiocarbonate Analogs As Therapeutic Agents
The present invention provides a compound represented by the general formula I; wherein A, Ar, X, Z, n, x, y, R and Rare as defined in the specification.
Cyclohexyl Prostaglandin Analogs As Ep-Receptor Agonists
David W. Old - Irvine CA, US Robert M. Burk - Laguna Beach CA, US Thang D. Dinh - Garden Grove CA, US
Assignee:
Allergan, Inc. - Irvine CA
International Classification:
A61K 31/38 C07D 327/04
US Classification:
514443, 514529, 549 32, 560 8, 560129
Abstract:
The invention relates to the use of novel cyclohexyl analogues of E-type prostaglandins as EPagonists, in general, and, in particular as ocular hypotensives. The cyclohexyl analogues used in accordance with the invention are represented by the following formula I: wherein the wavy segments represent α or β bond, dashed line represents the presence or absence of a bond W, Y, Z, R, R, Rand Rare as defined in the specification.
C-Terminal Modified Oxamyl Dipeptides As Inhibitors Of The Ice/Ced-3 Family Of Cysteine Proteases
This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
Wesley K. Masenten - Irvine CA, US Keith Soo Hoo - Long Beach CA, US Peter Stubberud - Henderson NV, US Thang Victor Dinh - Westminster CA, US Elias Dagher - Aliso Viejo CA, US
Assignee:
DiTrans IP, Inc. - Menlo Park CA
International Classification:
H04L 27/06
US Classification:
375316
Abstract:
An improved complex-IF digital receiver has various improvements. The improved complex-IF digital receiver, for single or dual band applications, preferably synchronizes all of the signals to each other, which may be an integer multiple of each other. For example, the decimation filter, delta-sigma modulator, sensitivity DAC, and other circuits in the receiver can be synchronized. The delta-sigma modulator preferably includes a comparator whose input is coupled to a sensitivity DAC or synchronous dithering circuit. Ideally, the sensitivity DAC forces the comparator to trigger at every clock cycle and reduces the effect of hysteresis and offset at the input of the comparator. The receiver includes a translation circuit that translates an intermediate frequency signal to baseband, where the translation circuit preferably operates a translation ratio that is a multiple of 4.
C-Terminal Modified Oxamyl Dipeptides As Inhibitors Of The Ice/Ced-3 Family Of Cysteine Proteases
Donald S Karanewsky - Escondido CA, US Robert J Ternansky - San Diego CA, US Steven D Linton - San Diego CA, US Thang Dinh - Garden Grove CA, US
Assignee:
Idun Pharmaceuticals, Inc. - San Diego CA
International Classification:
C07K 5/06
US Classification:
514 19, 548517, 548527, 544360, 5462784
Abstract:
This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
Cyclohexyl Prostaglandin Analogs As Ep-Receptor Agonists
David W. Old - Irvine CA, US Robert M. Burk - Laguna Beach CA, US Thang D. Dinh - Garden Grove CA, US
Assignee:
Allergan, Inc. - Irvine CA
International Classification:
A61K 31/38 C07D 327/04
US Classification:
514443, 514529, 549 8, 560129
Abstract:
The invention relates to the use of novel cyclohexyl analogues of E-type prostaglandins as EPagonists, in general, and, in particular as ocular hypotensives. The cyclohexyl analogues used in accordance with the invention are represented by the following formula I:.