Theo Michels

US Patent:

20230071483, Mar 9, 2023

Filed:

Apr 14, 2022

Appl. No.:

17/720529

Inventors:

- San Diego CA, US
Siegfried H. Reich - La Jolla CA, US
Paul A. Sprengeler - Escondido CA, US
Chinh Viet TRAN - San Diego CA, US
Garrick Kenneth PACKARD - San Diego CA, US
Alan X. XIANG - Irvine CA, US
Christian NILEWSKI - La Jolla CA, US
Theo MICHELS - San Diego CA, US

International Classification:

C07D 491/048
C07D 307/93
C07D 333/78
C07D 491/153
C07D 491/16
C07D 491/20
C07D 498/14
C07D 519/00

Abstract:

The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof.For Formula I compounds X, Y, R, R, R, R, R, Rand Rare as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4A and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.

US Patent:

20200339590, Oct 29, 2020

Filed:

Feb 28, 2020

Appl. No.:

16/804937

Inventors:

- San Diego CA, US
Siegfried H. Reich - La Jolla CA, US
Paul A. Sprengeler - Escondido CA, US
Chinh Viet Tran - San Diego CA, US
Garrick Kenneth Packard - San Diego CA, US
Alan X. Xiang - Irvine CA, US
Christian Nilewski - La Jolla CA, US
Theo Michels - San Diego CA, US

Assignee:

eFector Therapautics, Inc. - San Diego CA

International Classification:

C07D 491/048
C07D 307/93
C07D 333/78
C07D 491/153
C07D 491/16
C07D 491/20
C07D 498/14
C07D 519/00

Abstract:

The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof.For Formula I compounds X, Y, R, R, R, R, R, Rand Rare as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4A and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.

US Patent:

20180298017, Oct 18, 2018

Filed:

Mar 12, 2018

Appl. No.:

15/917973

Inventors:

- San Diego CA, US
Siegfried H. REICH - La Jolla CA, US
Paul A. SPRENGELER - Escondido CA, US
Chinh Viet TRAN - San Diego CA, US
Garrick Kenneth PACKARD - San Diego CA, US
Alan X. XIANG - Irvine CA, US
Christian NILEWSKI - La Jolla CA, US
Theo MICHELS - San Diego CA, US

Assignee:

eFFECTOR Therapeutics, Inc. - San Diego CA

International Classification:

C07D 491/048
C07D 519/00
C07D 333/78
C07D 307/93
C07D 491/16
C07D 491/20
C07D 498/14
C07D 491/153

Abstract:

The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof.For Formula I compounds X, Y, R, R, R, R, R, Rand Rare as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4A and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.

US Patent:

20170145026, May 25, 2017

Filed:

Nov 22, 2016

Appl. No.:

15/358761

Inventors:

- San Diego CA, US
Siegfried H. REICH - La Jolla CA, US
Paul A. SPRENGELER - Escondido CA, US
Chinh Viet TRAN - San Diego CA, US
Garrick Kenneth PACKARD - San Diego CA, US
Alan X. XIANG - Irvine CA, US
Christian NILEWSKI - La Jolla CA, US
Theo MICHELS - San Diego CA, US

International Classification:

C07D 491/048
C07D 491/20
C07D 519/00
C07D 498/14
C07D 491/16
C07D 491/153
C07D 333/78
C07D 307/93

Abstract:

The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof.For Formula I compounds X, Y, R, R, R, R, R, Rand Rare as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4A and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.