Theodore H Clark

US Patent:

20190144538, May 16, 2019

Filed:

May 2, 2017

Appl. No.:

16/098670

Inventors:

- Arlington MA, US
Janna Bednenko - Woburn MA, US
Yelena Bisharyan - Arlington MA, US
Ashot Papoyan - Arlington MA, US
Joanna Cardarelli - Charlestown MA, US
Theodore G. Clark - Ithaca NY, US
Douglas Kahn - Boston MA, US
Lore Mariën - Gent, BE
Bas Van Der Woning - Bachte-Maria-Leerne, NL
Hans De Haard - Oudelande, NL
William D. Harriman - Alameda CA, US
Ellen J. Collarini - Oakland CA, US

Assignee:

Tetragenetics, Inc. - Arlington MA

International Classification:

C07K 16/28
C07K 16/44
A61P 37/06

Abstract:

Anti-Kv1.3 antibodies (mAbs), particularly mAbs that specifically bind to Kv1.3 with high affinity and/or inhibit Kv1.3 function, are disclosed. The amino acid sequences of the CDRs of the light chains and the heavy chains, as well as consensus sequences for these CDRs, of these anti-Kv1.3 mAbs are provided. Additionally, canonical structures for CDRs in the VH and VL regions of anti-Kv1.3 antibodies are provided. The disclosure also provides nucleic acid molecules encoding the anti-Kv1.3 mAbs, expression vectors, host cells, methods for making the anti-Kv1.3 mAbs, and methods for expressing the anti-Kv1.3 mAbs. Finally, methods of using the anti-Kv1.3 mAbs as therapeutics, such as for preventing or treating an autoimmune disorder, are disclosed.

US Patent:

20170089921, Mar 30, 2017

Filed:

May 5, 2015

Appl. No.:

15/306869

Inventors:

- Arlington MA, US
Ashot PAPOYAN - Arlington MA, US
Yelena BISHARYAN - Arlington MA, US
Janna BEDNENKO - Woburn MA, US
Theodore G. CLARK - Ithaca NY, US

International Classification:

G01N 33/68
C07K 16/00
G01N 33/92
C07K 1/00
C12N 1/10
C12N 15/79

Abstract:

Methods are disclosed for the production of mammalian voltage-gated ion channels in ciliates. In other aspects, compositions comprising lipid bilayers containing mammalian voltage-gated ion channels are disclosed. In other aspects, compositions comprising purified and reconstituted mammalian voltage-gated ion channels are disclosed.