Theodore A Tyler

US Patent:

20080103193, May 1, 2008

Filed:

Oct 26, 2006

Appl. No.:

11/586889

Inventors:

Trevor Percival Castor - Arlington VA, US
Lorraine C. Rosenberry - Newcastle ME, US
Theodore A. Tyler - Framingham MA, US
Richard J. Student - Hubbardston MA, US

International Classification:

A61K 31/353
C07D 311/80

US Classification:

514454, 549390

Abstract:

The present invention pertains to methods for making compositions and compositions for treating pain and cachexia or AIDS wasting. In particular, the instant invention employs methods for making Δ9-tetrahydrocannabinol (Δ9-THC) and Δ9-tetrahydrocannabinolic acid (Δ9-THCA) from , and compositions for the treatment of these diseases.

US Patent:

62912410, Sep 18, 2001

Filed:

Mar 29, 1999

Appl. No.:

9/280366

Inventors:

Trevor Percival Castor - Arlington MA
Theodore Abraham Tyler - Framingham MA
Richard Joseph Student - Hubbardston MA

International Classification:

B01D 5940
C02F 100
C12N 500
C12N 502

US Classification:

435410

Abstract:

St. John's Wort products which have enhanced bioactivity in a serotonin re-uptake assay and enhanced stability are identified and manufactured from Hypericum perforatum biomass with supercritical and near critical fluids with and without polar cosolvents. These fluids are used to fractionate the biomass materials in several sequential steps. In each step, the biomass is subjected to a multiplicity of supercritical or near critical fluid extraction steps, with different solvation conditions used for each fraction. Thus, fractionation of the biomass is effected and the St. John's Wort products are manufactured. In addition to excellent overall yield, the bioactivity and stability of the St. John's Wort products manufactured from Hypericum perforatum biomass with supercritical and near critical fluids with and without polar cosolvents are significantly higher than that obtained by conventional organic phase extraction.

US Patent:

20150246000, Sep 3, 2015

Filed:

May 18, 2015

Appl. No.:

14/714433

Inventors:

- Woburn MA, US
- Shreveport LA, US
Geoffrey Purdum - Hamilton NJ, US
J. David Rios - Burlington MA, US
Lisa M. Schrott - Decatur GA, US
Theodore A. Tyler - Framingham MA, US
Maria I. Vizcaino - New Haven CT, US

International Classification:

A61K 9/51
A61K 31/365

Abstract:

Embodiments of the present invention are directed to the oral administration of Bryostatins for the treatment of neuro-degenerative disease.