Theresa Baden Britschgi

US Patent:

57703736, Jun 23, 1998

Filed:

Nov 8, 1996

Appl. No.:

8/745638

Inventors:

Theresa B. Britschgi - Seattle WA
Gerard A. Cangelosi - Seattle WA

Assignee:

Becton Dickinson and Company - Franklin Lakes NJ

International Classification:

C12Q 168

US Classification:

435 6

Abstract:

The invention relates to methods and oligonucleotide probe compositions useful for determining antibiotic resistance in Mycobacteria. Included are methods for freeing intact precursor ribosomal RNA from mycobacterial cells and for assaying the levels of pre-rRNA in the cells. Also claimed are methods useful in discovering new anti-mycobacterial therapeutic agents.

US Patent:

57766940, Jul 7, 1998

Filed:

Jul 2, 1997

Appl. No.:

8/886999

Inventors:

Diana K. Sheiness - Bothell WA
Trevor H. Adams - Buckinghamshire, GB2
Michael R. Stamm - Bothell WA
Gerard A. Cangelosi - Seattle WA
Theresa B. Britschgi - Seattle WA
Connie K. Dix - Arlington WA

Assignee:

Becton Dickinson Company - Franklin Lakes NJ

International Classification:

C12Q 168
C07H 2104

US Classification:

435 6

Abstract:

The present invention relates, in general, to diagnostic kits for selectively detecting a prokaryotic microorganism and a eukaryotic microorganism in a sample wherein the cells of such microorganisms are lysed by combining the sample with a lysis solution and contacting the nucleic acid released from the microorganisms with selective nucleic acid probes through hybridization techniques. The present invention can be used for detecting microorganisms associated with vaginal disorders, e. g. , Gardnerella vaginalis, Trichomonas vaginalis and Candida albicans. These kits may be used in a medical practitioner's private office or in a more structured clinical environment, such as a hospital, a commercial clinical microbiology laboratory or the like.

US Patent:

57260214, Mar 10, 1998

Filed:

Nov 27, 1996

Appl. No.:

8/757180

Inventors:

Theresa B. Britschgi - Seattle WA
Gerard A. Cangelosi - Seattle WA

Assignee:

Becton Dickinson and Company - Franklin Lakes NJ

International Classification:

C12Q 168
C12Q 100

US Classification:

435 6

Abstract:

The invention relates to methods and compositions useful for rapidly freeing precursor ribosomal RNA from mycobacterial cells. The methods and compositions further result in detectable levels of ribosomal RNA precursors that are not degraded.

US Patent:

57120951, Jan 27, 1998

Filed:

Jun 7, 1995

Appl. No.:

8/485602

Inventors:

Theresa B. Britschgi - Seattle WA
Gerard A. Cangelosi - Seattle WA

Assignee:

Becton Dickinson and Company - Franklin Lakes NJ

International Classification:

C12Q 168
C07H 2104
C07H 2102

US Classification:

435 6

Abstract:

The invention relates to methods and oligonucleotide probe compositions useful for determining antibiotic resistance in Mycobacteria. Included are methods for freeing intact precursor ribosomal RNA from mycobacterial cells and for assaying the levels of pre-rRNA in the cells. Also claimed are methods useful in discovering new anti-mycobacterial therapeutic agents.