Matthew K. Waldor - Newton MA, US Theresa D. Ho - Somerville MA, US
International Classification:
A61K 39/02 C12N 1/21
US Classification:
4242001, 43525233
Abstract:
The present invention provides methods and compositions for production of gram-negative bacterial mutants that are defective in intestinal colonization capacity and sensitive to infection by bacteriophage P1. Thus the present invention provides immunogenic compositions for the prevention or attenuation of food- and water-borne illnesses associated with ingestion of bacteria such as enterohemorrhagic