Theresa B O'Keefe

US Patent:

20110110936, May 12, 2011

Filed:

Oct 22, 2010

Appl. No.:

12/910393

Inventors:

Samuel S. Nam - Haverhill MA, US
Edward A. Greenfield - Stoughton MA, US
Theresa L. O'Keefe - Waltham MA, US
Shixin Qin - Lexington MA, US
John Babcook - Vancouver, CA

International Classification:

A61K 39/395
C07K 16/40
C07H 21/00
C12N 5/10
C12P 21/00
G01N 33/573
A61P 35/00

US Classification:

4241331, 5303891, 5303873, 4241581, 536 2353, 435325, 435 696, 435 74

Abstract:

Antibodies and antigen-binding fragments of antibodies that bind GCC are disclosed. The antibodies bind an extracellular domain of GCC and can be internalized. In some embodiments, the antibodies are humanized, chimeric or human. Nucleic acids and vectors encoding the antibodies or portions thereof, recombinant cells that contain the nucleic acids, and compositions comprising the antibodies or antigen-binding fragments are also disclosed. The invention also provides therapeutic and diagnostic methods utilizing the antibodies and antigen-binding fragments provided herein.

US Patent:

20190328912, Oct 31, 2019

Filed:

Sep 23, 2016

Appl. No.:

15/330469

Inventors:

- Burlington MA, US
John Erickson - Middleton MA, US
Theresa L. O'Keefe - Waltham MA, US

International Classification:

A61L 2/00
A61L 2/12
A61L 2/18
A61L 2/24
A61L 2/22

Abstract:

A system for sterilizing and/or deimmunizing an object includes a stationary chamber at ambient pressure configured to store an object to be sterilized and/or deimmunized therein. An electromagnetic device is coupled to the chamber and configured to direct microwaves at the object. A solvent spray subsystem is coupled to the chamber and configured to apply a solvent to the object such that the object is completely coated and/or saturated with the solvent. A controller subsystem coupled to the electromagnetic device and the solvent spray subsystem is configured to provide a cycle of activating the solvent spray subsystem for a predetermined amount of time, activating the electromagnetic device for a predetermined amount of time, and repeating the cycle a predetermined amount of times to irreversibly destroy proteins on the object to sterilize and/or deimmunize the object.

US Patent:

20140322233, Oct 30, 2014

Filed:

Jun 2, 2014

Appl. No.:

14/293802

Inventors:

Samuel S. Nam - Haverhill MA, US
Edward A. Greenfield - Stoughton MA, US
John S. Babcook - Vancouver, CA
Theresa O'Keefe - Waltham MA, US
Shixin Qin - Lexington MA, US

International Classification:

C07K 16/40
G01N 33/573
A61K 39/395
A61K 47/48

US Classification:

4241581, 5303891, 5303913, 5303917, 536 2353, 435334, 435 696, 4353201, 435 721

Abstract:

Antibodies and antigen-binding fragments of antibodies that bind GCC are disclosed. The antibodies bind an extracellular domain of GCC and can be internalized. In some embodiments, the antibodies are humanized, chimeric or human. Nucleic acids and vectors encoding the antibodies or portions thereof, recombinant cells that contain the nucleic acids, and compositions comprising the antibodies or antigen-binding fragments are also disclosed. The invention also provides therapeutic and diagnostic methods utilizing the antibodies and antigen-binding fragments provided herein.