Theresa L O'Keefe from 7 Bourne Hay Rd, Sandwich, MA 02563, age 55

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Monoclonal Antibodies Against Hmgb1
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US Patent:

7288250, Oct 30, 2007
Filed:

Sep 10, 2004
Appl. No.:

10/938992
Inventors:

Walter Newman - Boston MA, US
Shixin Qin - Lexington MA, US
Theresa L. O'Keefe - Waltham MA, US
Robert A. Obar - Walpole MA, US
Assignee:

Critical Therapeutics, Inc. - Lexington MA
International Classification:

A61K 39/395
C07K 16/24
US Classification:

4241331, 4241451, 435810, 435335, 435355, 5303873, 5303881, 53038823
Abstract:

In various embodiments, the present invention is drawn to antibodies or antigen-binding fragments thereof that bind to a vertebrate high mobility group box (HMGB) polypeptide, methods of detecting and/or identifying an agent that binds to an HMGB polypeptide, methods of treating a condition in a subject characterized by activation of an inflammatory cytokine cascade and methods of detecting an HMGB polypeptide in a sample.

Humanized Anti-Ccr2 Antibodies And Methods Of Use Therefor
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US Patent:

7442775, Oct 28, 2008
Filed:

Jan 27, 2004
Appl. No.:

10/766610
Inventors:

Gregory J. LaRosa - Newton MA, US
Christopher Horvath - Taunton MA, US
Walter Newman - Boston MA, US
S. Tarran Jones - Radlett, GB
Siobhan H. O'Brien - London, GB
Theresa O'Keefe - Waltham MA, US
Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA
International Classification:

C07H 23/00
A61K 39/00
C12N 15/00
US Classification:

5303879, 536 2353, 4353201, 435328
Abstract:

The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e. g. , human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.

Humanized Anti-Ccr2 Antibodies And Methods Of Use Therefor
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US Patent:

7473421, Jan 6, 2009
Filed:

Jan 27, 2004
Appl. No.:

10/766773
Inventors:

Gregory J. LaRosa - Newton MA, US
Christopher Horvath - Taunton MA, US
Walter Newman - Boston MA, US
S. Tarran Jones - Radlett, GB
Siobhan H. O'Brien - London, GB
Theresa O'Keefe - Waltham MA, US
Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA
International Classification:

C07K 16/00
A61K 39/02
US Classification:

4241391, 435 696, 435 5
Abstract:

The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e. g. , human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.

Humanized Anti-Ccr2 Antibodies And Methods Of Use Therefor
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US Patent:

7566450, Jul 28, 2009
Filed:

Oct 26, 2007
Appl. No.:

11/924794
Inventors:

Gregory J. LaRosa - Newton MA, US
Christopher J. Horvath - Taunton MA, US
Walter Newman - Boston MA, US
S. Tarran Jones - Hertfordshire, GB
Siobhan H. O'Brien - London, GB
Theresa O'Keefe - Waltham MA, US
Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA
International Classification:

A61K 39/395
US Classification:

4241391, 4241421, 4241431
Abstract:

The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e. g. , human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.

Monoclonal Antibodies Against Hmgb1
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US Patent:

7632500, Dec 15, 2009
Filed:

Sep 20, 2007
Appl. No.:

11/903129
Inventors:

Walter Newman - Boston MA, US
Shixin Qin - Lexington MA, US
Theresa L. O'Keefe - Waltham MA, US
Robert A. Obar - Walpole MA, US
Assignee:

Cornerstone Therapeutics, Inc. - Cary NC
International Classification:

A61K 39/395
C07K 16/24
US Classification:

4241341, 4241451, 435810, 5303873
Abstract:

In various embodiments, the present invention is drawn to antibodies or antigen-binding fragments thereof that bind to a vertebrate high mobility group box (HMGB) polypeptide, methods of detecting and/or identifying an agent that binds to an HMGB polypeptide, methods of treating a condition in a subject characterized by activation of an inflammatory cytokine cascade and methods of detecting an HMGB polypeptide in a sample.

Humanized Anti-Ccr2 Antibodies And Methods Of Use Therefor
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US Patent:

8227211, Jul 24, 2012
Filed:

Sep 23, 2008
Appl. No.:

12/235765
Inventors:

Gregory J. LaRosa - Newton MA, US
Christopher Horvath - Taunton MA, US
Walter Newman - Boston MA, US
S. Tarran Jones - Hertfordshire, GB
Siobhan H. O'Brien - Herts, GB
Theresa O'Keefe - Waltham MA, US
Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA
International Classification:

A61K 39/395
C12N 15/13
C07K 16/00
US Classification:

435 696, 43525231, 43525233, 43525411, 435375, 4241331, 5303873
Abstract:

The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e. g. , human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.

Humanized Anti-Ccr2 Antibodies And Methods Of Use Therefor
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US Patent:

20020150576, Oct 17, 2002
Filed:

Apr 23, 2001
Appl. No.:

09/840459
Inventors:

Gregory LaRosa - Newton MA, US
Christopher Horvath - Taunton MA, US
Walter Newman - Boston MA, US
S. Jones - Radlett, GB
Siobhan O'Brien - London, GB
Theresa O'Keefe - Waltham MA, US
International Classification:

A61K039/395
C07K016/40
US Classification:

424/142100, 530/388150
Abstract:

The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.

Humanized Anti-Ccr2 Antibodies And Methods Of Use Therefor
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US Patent:

20080241923, Oct 2, 2008
Filed:

Oct 25, 2007
Appl. No.:

11/924153
Inventors:

Gregory J. LaRosa - Newton MA, US
Christopher J. Horvath - Taunton MA, US
Walter Newman - Boston MA, US
S. Tarran Jones - Hertfordshire, GB
Siobhan H. O'Brien - London, GB
Theresa O'Keefe - Waltham MA, US
Assignee:

MILLENNIUM PHARMACEUTICALS, INC. - Cambridge MA
International Classification:

C12N 5/06
US Classification:

435375
Abstract:

The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.