Thomas F Barnett

US Patent:

6342583, Jan 29, 2002

Filed:

Mar 8, 1993

Appl. No.:

08/027974

Inventors:

Thomas R. Barnett - East Haven CT
James J. Elting - Madison CT
Michael E. Kamarck - Bethany CT
Axel W. Kretschmer - Wulfrath, DE

Assignee:

Bayer Corporation - Tarrytown NY

International Classification:

C07K 1400

US Classification:

530350

Abstract:

A nucleic acid comprising a base sequence which codes for a CEA family member peptide sequence or nucleic acids having a base sequence hybridizable therewith, replicable recombinant cloning vehicles having an insert comprising such nucleic acid, cells transfected, infected or injected with such cloning vehicles, polypeptides expressed by such cells, synthetic peptides derived from the coding sequence of CEA family member nucleic acids, antibody preparations specific for such polypeptides, immunoassays for detecting CEA family members using such antibody preparations and nucleic acid hybridization methods for detecting CEA family member nucleic acid sequences using a nucleic acid probe comprising the above described nucleic acid.

US Patent:

52310094, Jul 27, 1993

Filed:

Sep 13, 1991

Appl. No.:

7/760031

Inventors:

Thomas R. Barnett - East Haven CT
James J. Elting - Madison CT
Michael E. Kamarck - Bethany CT
Axel W. Kretschmer - Wulfrath, DE

Assignee:

Molecular Diagnostics, Inc. - West Haven CT

International Classification:

C12N 5710
C12N 121

US Classification:

4352402

Abstract:

A nucleic acid comprising a base sequence which codes for a CEA family member peptide sequence or nucleic acids having a base sequence hybridizable therewith, replicable recombinant cloning vehicles having an insert comprising such nucleic acid, cells transfected, infected or injected with such cloning vehicles, polypeptides expressed by such cells, synthetic peptides derived from the coding sequence of CEA family member nucleic acids, antibody preparations specific for such polypeptides, immunoassays for detecting CEA family members using such antibody preparations and nucleic acid hybridization methods for detecting CEA family member nucleic acid sequences using a nucleic acid probe comprising the above described nucleic acid.

US Patent:

55717101, Nov 5, 1996

Filed:

Dec 20, 1993

Appl. No.:

8/170134

Inventors:

Thomas R. Barnett - East Haven CT
James J. Elting - Madison CT
Michael E. Kamarck - Bethany CT

Assignee:

Bayer Corporation - Tarrytown NY

International Classification:

C12N 506
C12N 1500
C12N 1512
C07H 2104

US Classification:

4352401

Abstract:

A nucleic acid encoding a carcinoembryonic antigen (CEA) that cross-reacts with human CEA is described. In addition, vectors and host cells containing such nucleic acids are disclosed.

US Patent:

52740870, Dec 28, 1993

Filed:

Apr 29, 1992

Appl. No.:

7/876821

Inventors:

Thomas R. Barnett - East Haven CT
James J. Elting - Madison CT
Michael E. Kamarck - Bethany CT

Assignee:

Molecular Diagnostics, Inc. - West Haven CT

International Classification:

C07H 1512
C07H 2104
C12N 1500

US Classification:

536 235

Abstract:

Nucleic acid sequences are disclosed that encode carcinoembryonic antigens (CEAs) as are replicable recombinant cloning vehicles containing DNA that encodes CEA proteins.

US Patent:

51225999, Jun 16, 1992

Filed:

Nov 21, 1988

Appl. No.:

7/274107

Inventors:

Thomas R. Barnett - East Haven CT
James J. Elting - Madison CT
Michael E. Kamarck - Bethany CT
Axel W. Kretschmer - Wulfrath, DE

Assignee:

Molecular Diagnostics, Inc. - West Haven CT

International Classification:

C07H 1512
C12Q 168
C12N 1500

US Classification:

536 27

Abstract:

This invention relates to a nucleic acid comprising a base sequence which codes for a CEA family member peptide sequence or nucleic acids having a base sequence hybridizable therewith, replicable recombinant cloning vehicles having an insert comprising such nucleic acid, cells transfected, infected or injected with such cloning vehicles, polypeptides expressed by such cells, synthetic peptides derived from the coding sequence of CEA family member nucleic acids, antibody preparations specific for such polypeptides, immunoassays for detecting CEA family members using such antibody preparations and nucleic acid hybridization methods for detecting CEA family member nucleic acid sequences using a nucleic acid probe comprising the above described nucleic acid.

US Patent:

6013772, Jan 11, 2000

Filed:

Jun 6, 1995

Appl. No.:

8/468856

Inventors:

Thomas R. Barnett - East Haven CT
James J. Elting - Madison CT
Michael E. Kamarck - Bethany CT
Axel W. Kretschmer - Wulfrath, DE

Assignee:

Bayer Corporation - Tarrytown NY

International Classification:

C07K 1630
G01N 3353

US Classification:

5303877

Abstract:

A nucleic acid comprising a base sequence which codes for a CEA family member peptide sequence or nucleic acids having a base sequence hybridizable therewith, replicable recombinant cloning vehicles having an insert comprising such nucleic acid, cells transfected, infected or injected with such cloning vehicles, polypeptides expressed by such cells, synthetic peptides derived from the coding sequence of CEA family member nucleic acids, antibody preparations specific for such polypeptides, immunoassays for detecting CEA family members using such antibody preparations and nucleic acid hybridization methods for detecting CEA family member nucleic acid sequences using a nucleic acid probe comprising the above described nucleic acid.

US Patent:

60229586, Feb 8, 2000

Filed:

Jun 6, 1995

Appl. No.:

8/468859

Inventors:

Thomas R. Barnett - East Haven CT
James J. Elting - Madison CT
Michael E. Kamarck - Bethany CT
Axel W. Kretschmer - Wulfrath, DE

Assignee:

Bayer Corporation - Tarrytown NY

International Classification:

C07H 2104
C12N 1511
C12N 121
C12N 1579

US Classification:

536 231

Abstract:

A nucleic acid comprising a base sequence which codes for a CEA family member peptide sequence or nucleic acids having a base sequence hybridizable therewith, replicable recombinant cloning vehicles having an insert comprising such nucleic acid, cells transfected, infected or injected with such cloning vehicles, polypeptides expressed by such cells, synthetic peptides derived from the coding sequence of CEA family member nucleic acids, antibody preparations specific for such polypeptides, immunoassays for detecting CEA family members using such antibody preparations and nucleic acid hybridization methods for detecting CEA family member nucleic acid sequences using a nucleic acid probe comprising the above described nucleic acid.

US Patent:

55938477, Jan 14, 1997

Filed:

Dec 20, 1993

Appl. No.:

8/170141

Inventors:

Thomas R. Barnett - Prospect CT
James J. Elting - Madison CT
William J. Allard - Poughquag NY

Assignee:

Bayer Corporation - Tarrytown NY

International Classification:

G01N 33574
G01N 3353
C07K 1600
C12P 2108

US Classification:

435 723

Abstract:

A method for aiding in the diagnosis of, and monitoring the progression of, breast cancer in a patient by measuring the amount of NCA 50/90 in a blood sample, e. g. serum sample, obtained from the patient. Measurement in a single sample of an amount of NCA 50/90 significantly higher than the mean amount of NCA 50/90 in the normal population is an indication of breast cancer in the patient. The progression of breast cancer can also be monitored by performing a series of specific immunoassays over time to determine changes in the level of NCA 50/90 in blood samples. Increases in blood NCA 50/90 levels over time are indicative of a deteriorating condition whereas decreasing levels of blood NCA 50/90 over time indicate an improving condition.